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CDX2 — A protein that promotes leukemia
Researchers from Harvard Medical School, Boston, have found that most individuals with acute myeloid leukemia (AML) inappropriately express a protein known as CDX2 in their leukemic cells.   view more (2007-03-08)

U-M team identifies gene that regulates blood-forming fetal stem cells
In the rancorous public debate over federal research funding, stem cells are generally assigned to one of two categories: embryonic or adult.   view more (2007-07-27)

Role of the nervous system in regulating stem cells discovered
New study by Mount Sinai researchers may lead to improved stem cell therapies for patients with compromised immune systems due to intensive cancer therapy or autoimmune disease.   view more (2006-01-27)

Bones hold the key to blood renewal
Though we think of them as solid and permanent, our bones are actually constantly being rebuilt throughout our lives. A team of scientists at the Weizmann Institute of Science has now revealed how cells that work at remodeling the bones play a direct part in the ongoing renewal of another system... view more (2006-06-20)

Study suggests use of stem cell transplantation is beneficial treatment of type 1 diabetes
A therapy that includes stem cell transplantation induced extended insulin independence in patients with type 1 diabetes mellitus.   view more (2007-04-11)

New hope for regenerative medicine
In the February 15th issue of G&D, Dr. K. John McLaughlin and colleagues report on their success in using uniparental embryonic stem cells to replace blood stem cells in mice.   view more (2007-02-15)

Powerful technique for multiplying adult stem cells may aid therapies
Adult stem cells may be free of the ethical concerns that hamper embryonic stem cell research, but they still pose formidable scientific challenges. Chief among these is the doggedness with which adult stem cells differentiate into mature tissue the moment they're isolated from the body.   view more (2006-01-23)

Blood stem cells fight invaders, study finds
No other stem cell is more thoroughly understood than the blood, or hematopoietic, stem cell.   view more (2007-11-30)

Inflammation triggers cell fusions that could protect neurons, Stanford research shows
Chronic inflammation triggers bone marrow-derived blood cells to travel to the brain and fuse with a certain type of neuron up to 100 times more frequently than previously believed, according to a new study from the Stanford University School of Medicine.   view more (2008-04-21)

Research shows promise for using stem cell transplantation to treat patients with severe lupus
About half of patients with severe lupus that was refractory to standard treatment and who underwent autologous stem cell transplantation to improve their immune system have substantial improvement in disease activity after several years.   view more (2006-02-01)

A functional immune system can be derived from embryonic stem cells, preliminary study finds
A new study demonstrates for the first time that embryonic stem cells can be used to create functional immune system blood cells, a finding which is an important step in the utilization of embryonic stem cells as an alternative source of cells for bone marrow transplantation.   view more (2008-02-13)

Master regulatory gene found that guides fate of blood-producing stem cells
Researchers from the University of Pennsylvania School of Medicine found that a protein called NF-Ya activates several genes known to regulate the development of hematopoietic stem cells (HSC), or blood-producing stem cells, in bone marrow.   view more (2005-08-02)

Discoveries may advance stem cell therapy for Parkinson's, cancer patients
Two studies in the Jan. 27, 2006 Cell have yielded evidence that could prove a boon for stem cell therapies aimed at patients with Parkinson's disease and those with compromised immune systems due to intensive cancer therapy or autoimmune disease, according to researchers.   view more (2006-01-27)

St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels
Investigators at St. Jude Children's Research Hospital settled a century-old debate on the origin of the mammalian lymphatic vasculature-the network of vessels and capillaries critical to various essential housekeeping functions in the body. The finding holds the promise for the development of new... view more (2007-10-04)

Lost in the labyrinth
Blood cells have limited lifespans, which means that they must be continually replaced by calling up reserves, and turning these into the blood cell types needed by the body.   view more (2006-09-05)

Sickle cell disease corrected in human models using stem cell-based gene therapy
In a study to be published in the January 2006 issue of Nature Biotechnology, researchers led by a team of scientists at Memorial Sloan-Kettering Cancer Center have devised a novel strategy that uses stem cell-based gene therapy and RNA interference to genetically reverse sickle cell disease (SCD)... view more (2005-12-29)

Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment
Recent discoveries about the role of stem cells in cancer have altered the landscape of cancer research. With each new study, scientists are learning more about cancer-initiating properties of stem cells at organ sites and throughout the body.   view more (2007-04-19)

U of MN researchers identify new cord blood stem cell
Researchers at the University of Minnesota Medical School have discovered a new population of cells in human umbilical cord blood that have properties of primitive stem cells.   view more (2006-02-14)

Mad-cow culprit maintains stem cells
What do mad cow disease and stem cell research have in common? Whitehead Institute scientists have found that the same protein that causes neurodegenerative conditions such as bovine spongiform encephalopathy (mad cow disease) is also important for helping certain adult stem cells maintain... view more (2006-01-31)

Ago2 and hematopoiesis
Argonaute 2 (Ago2) is unique among its family: It is the only one of the four mammalian Argonaute proteins that exhibits endonuclease "slicer" activity (facilitation of miRNA-guided cleavage of target mRNA).   view more (2007-07-12)

St. Jude researchers find key step in programmed cell death
Investigators at St. Jude Children's Research Hospital have discovered a dance of proteins that protects certain cells from undergoing apoptosis, also known as programmed cell death. Understanding the fine points of apoptosis is important to researchers seeking ways to control this process.   view more (2008-03-03)

Can you hear me now? Scientists find previously unknown receptors on adult stem cells
For many years, researchers believed that stem cells in the bone marrow spent most of their existence in a slumber-like state, unaware of — and unaffected by — the daily battles fought by the body's immune system.   view more (2006-06-21)

Cloned mice created from fully differentiated cells, a milestone in cloning research
New research dismisses the notion that adult stem cells are necessary for successful animal cloning, proving instead that cells that have completely evolved to a specific type not only can be used for cloning purposes, but they may be a better and more efficient starting point.   view more (2006-10-02)

Predicting acute GVHD by gene expression could improve liver stem cell transplant outcomes
Many cell transplants involve the use of stem cells from another human being (known as an allograft), which raises the major concern of the potential for acute graft-versus-host disease (GVHD).   view more (2008-07-21)

Predicting the risk of a common fungal infection after stem cell transplantation
In silico genetic analysis in mice has led to the discovery of a gene affecting susceptibility to a severe fungal infection in transplant recipients.   view more (2008-06-20)
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