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Increased hepcidin expression: A novel oncogenic signalling mechanism
Historically anaemia, which is associated with colorectal cancer, has been attributed to blood loss. Previous studies have elegantly shown that the anti-microbial peptide hepcidin can also induce anaemia as a consequence of infection and or inflammation. view more (2008-03-19)
Metabolic insight to illuminate causes of iron imbalance
New insight into key players in iron metabolism has yielded a novel tool for distinguishing among root causes of iron overload or deficiency in humans, the researchers report in the August issue of Cell Metabolism, a publication of Cell Press. While the body needs iron to produce hemoglobin, a substance in red blood cells that enables them to... view more... (2008-08-06)
Key site in iron metabolism aids in diagnosing anemia of chronic disease
University of Utah School of Medicine researchers have developed a new tool that facilitates diagnosis of anemia related to chronic illness, as well as diseases of iron overload. The results of a study detailing the new tool are published in the August 2008 issue of the journal Cell Metabolism, a publication of Cell Press. view more (2008-08-06)
Estrogen Linked to Lowered Immunity in Fish
Exposure to estrogen reduces production of immune-related proteins in fish. This suggests that certain compounds, known as endocrine disruptors, may make fish more susceptible to disease. view more (2009-06-04)
A genetic cause for iron deficiency
The discovery of a gene for a rare form of inherited iron deficiency may provide clues to iron deficiency in the general population - particularly iron deficiency that doesn't respond to iron supplements - and suggests a new treatment approach. view more (2008-04-14)
After a 40-year search, a hormone controlling iron metabolism in mammals is finally identified
Iron is vital for cells, because it catalyzes key enzyme reactions; it is also crucial for respiration, fixing atmospheric oxygen to hemoglobin in red blood cells. Iron deficiency can lead to severe anemia, with inadequate tissue oxygenation. An excess of iron is also toxic, as it facilitates the generation of free radicals that can attack the... view more... (2002-04-03)
What makes the body absorb too much iron? Researchers at EMBL and Harvard gain new insights into the most common inherited disease in the Western world
Like most nutrients, iron is good for people - in the right doses. When the body has enough iron, our cells stop absorbing it from food; if there is too little, they absorb more. This system breaks down in the most common inherited disease in the Western world: hemochromatosis, which affects about one in every 250 people and is often fatal if it... view more... (2003-04-29)
Hemochromatosis, Inflammation and Anemia: Researchers Discover a Surprising Link
Patients with inflammatory diseases such as arthritis, chronic infections and some types of cancer, often become anemic - a condition called anemia of chronic disease (ACD). While ACD rarely kills patients, it can make their lives miserable. A discovery at EMBL, in collaboration with researchers at Children's Hospital Boston and Harvard Medical... view more... (2004-04-15)
Europe's most common genetic disease is a liver disorder
Much less widely known than the dangerous consequences of iron deficiencies is the fact that too much iron can also cause problems. The exact origin of the genetic iron overload disorder hereditary hemochromatosis [HH] has remained elusive. view more (2008-02-07)
Unexpected link between gene in liver and iron overload
A new study in the December Cell Metabolism reveals an unexpected connection between a tumor suppressor gene in the liver and the normally careful control over the amount of iron absorbed from the diet. view more (2005-12-07)
MIT uncovers key blood protein
Scientists working in the only lab at MIT doing hematology research have uncovered a protein that plays a key role in the recycling of iron from blood. view more (2007-10-12)
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