Hippo Signaling Current Events | Hippo Signaling News
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New molecular insight into vertebrate brain development
In the December 1st issue of G&D, Dr. Fred H. Gage (The Salk Institute for Biological Studies) and colleagues reveal a role for the Hippo signaling pathway in the regulation of vertebrate neural development, identifying new factors - and potential therapeutic targets - that may be involved in congenital brain size disorders and neurological... view more... (2008-11-18)
Protein linked to growth of organs and cancer
Johns Hopkins scientists have identified a protein in fruit flies whose counterpart product in humans may help cause cancer. view more (2005-08-12)
Building the blood-brain barrier
Construction of the brain's border fence is supervised by Wnt/b-catenin signaling, report Liebner et al. in The Journal of Cell Biology. view more (2008-10-27)
Insulin signaling and amphetamines
Abuse of psychostimulants such as amphetamine remains a serious public health concern. Amphetamines mediate their behavioral effects by stimulating dopaminergic signaling throughout reward circuits of the brain. view more (2007-10-16)
Controlling for size may also prevent cancer
Scientists at Johns Hopkins recently discovered that a chemical chain reaction that controls organ size in animals ranging from insects to humans could mean the difference between normal growth and cancer. view more (2007-09-21)
Endosome-mediated signaling in plants
In a paper that will be published online in advance of its July 1st publication date, Drs. Niko Geldner, Joanne Chory and colleagues (The Salk Institute and HHMI) demonstrate that endosomes can function as signaling platforms in plants, as well as in animals. view more (2007-06-19)
Even Babies Can Have Optical Illusions
At the tender age of five months babies can be fooled by complex information about distances in drawings involving perspective, psychologists from the University of Bonn have shown. They fixed two rubber figures onto a picture on which a chessboard pattern appeared to be receding away from the babies. The babies then tried to grab the toy which... view more... (2005-04-06)
Anti-tumor effects are enhanced by inhibiting 2 pathways rather than 1
Two independent research groups have found that simultaneous inhibition of two signaling pathways resulted in substantially enhanced antitumor effects in mouse models of prostate and breast cancer. In an accompany commentary, Steven Grant, at Virginia Commonwealth University Health Science Center, Richmond, discusses the clinical importance of... view more... (2008-08-22)
Stem cell research uncovers mechanism for type 2 diabetes
Taking clues from their stem cell research, investigators at the University of California San Diego (UC San Diego) and Burnham Institute for Medical Research (Burnham) have discovered that a signaling pathway involved in normal pancreatic development is also associated with type 2 diabetes. view more (2009-02-13)
Tribble 3 can induce non-alcoholic fatty liver disease?
Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. view more (2009-06-11)
A new take on growth factor signaling in tamoxifen resistance
Differences in growth factor (GF) signaling may cause the poor prognosis in some breast cancer cases. A new study, published in the open access journal BMC Medical Genomics, suggests that some estrogen receptor-positive breast cancers respond poorly to tamoxifen because of increased GF signaling. view more (2009-06-24)
Mouse model underestimates the critical role of Tyk2 in human immune system
A new study identifies a human Tyk2 deficiency and definitively links this molecule with multiple cytokine signals that are critical for the human immune responses. view more (2006-11-10)
Penn researchers find key developmental pathway activates lung stem cells
Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to an increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair after injury or disease. view more (2008-06-18)
A crucial role for TGFbeta signaling in congenital eye disorders
The lens in the developing eye acts as a TGFbeta signaling center that controls differentiation, survival and formation of multiple eye structures deriving from the neural crest. view more (2005-12-14)
Role identified for glaucoma gene and related signaling pathway
Researchers have found that a gene and a related signaling pathway play a role in the development of glaucoma, which is a common cause of visual impairment and blindness worldwide. view more (2008-02-15)
Scientists take off on historic mission to measure greenhouse gases that have an impact on climate
HIAPER, one of the nation's most advanced research aircraft, is scheduled to embark on an historic mission spanning the globe from the Arctic to the Antarctic. view more (2009-01-08)
Unraveling how cells respond to low oxygen
Gary Chiang, Ph.D., and colleagues at Burnham Institute for Medical Research (Burnham) have elucidated how the stability of the REDD1 protein is regulated. view more (2009-08-06)
Researchers report the cloning of a key group of human genes, the protein kinases
Although the human genome has been sequenced, research into mechanism of action of genes has been hampered by the fact that most human genes have not been isolated. This is true for even the most common class of cancer-associated genes, the protein kinases, which mediate the majority of signaling events in cells by phosphorylating and modulating... view more... (2008-05-05)
What's the role of beta-catenin in colorectal cancers?
Beta-catenin, a central molecule of the Wnt-signaling pathway was previously known to involve in the tumorigenesis of various gastrointestinal cancers such as gastric cancer and colon cancer. view more (2008-11-03)
Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
During muscle regeneration, which is a natural response to injury and disease, environmental cues cause adult muscle stem cells (satellite cells) to shift from dormancy to actively building new muscle tissue. view more (2007-12-10)
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