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Hippo Signaling Current Events | Hippo Signaling News | 2
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Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
During muscle regeneration, which is a natural response to injury and disease, environmental cues cause adult muscle stem cells (satellite cells) to shift from dormancy to actively building new muscle tissue. view more (2007-12-10)
'Cross-talk' mechanism contributes to colorectal cancer
Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors. view more (2009-11-16)
Jefferson researchers uncover new evidence of prolactin's possible role in breast cancer
Scientists at the Kimmel Cancer Center at Jefferson in Philadelphia have discovered new molecular evidence of the role of the hormone prolactin in breast cancer. view more (2007-10-01)
GABA halts stem cell production in the brain
Release of the neurotransmitter GABA by adult neuronal precursor cells that develop into neurons limits stem cell proliferation, according to a study at Yale School of Medicine in the September issue of Nature Neuroscience. view more (2005-09-02)
Protein That Promotes Cancer Cell Growth Identified
Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate, migrate and invade surrounding tissues. view more (2009-07-27)
UCLA researchers discover new molecular pathway for targeting cancer, disease
A UCLA study has identified a way to turn off a key signaling pathway involved in physiological processes that can also stimulate the development of cancer and other diseases. The findings may lead to new treatments and targeted drugs using this approach. view more (2009-07-21)
Why the thumb of the right hand is on the left hand side
It is the concentration of a few signaling molecules that determines the fate of individual cells during the early development of organisms. view more (2009-05-22)
Executable biology -- Computer science sheds light on animal development
By applying the techniques of computer engineering to a mechanistic diagram describing the development of the Nematode C. elegans, a group of researchers in Switzerland has been able to tease out what laboratory experiments have not - how and when the crucial cross-talk between cellular signaling pathways takes place in order to determine the... view more... (2007-05-18)
Systems properties of insulin signaling revealed
A team of Swedish researchers has characterized novel systems properties of insulin signaling in human fat cells. Their mathematical modeling, described in an article published June 20th in the open-access journal PLoS Computational Biology, provides further insight into energy level maintenance (via the hormone insulin) within our bodies. view more (2008-06-20)
Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
Researchers have found a new oncogenic signaling pathway by which the environmental toxin arsenic may lead to adverse health effects, including bladder cancer. view more (2010-02-24)
Smoking out the mediators of airway damage caused by pollutants
New insight into how pollution and cigarette smoke damage airways has been provided by Pierangelo Geppetti and colleagues, at the University of Florence, Italy, who studied the effects of such chemicals on guinea pig airways. view more (2008-06-23)
Breast cancer treatment resistance linked to signaling pathway
Activation of the Src signaling pathway may cause resistance to standard medical treatment in some patients with breast cancer, and inhibition of this pathway holds the potential to overcome that resistance, according to data presented here at the American Association for Cancer Research Molecular Diagnostics in Cancer Therapeutic Development... view more... (2008-09-23)
Top notch decisions in the developing airways bring insights into lung disease
In the normal lung, the airways are lined by a balanced mixture of ciliated, secretory and neuroendocrine cells which perform functions as diverse as air humidification, detoxification, and clearance of environmental particles. view more (2009-06-09)
New brain cells implicated in machinery of cannabinoid signaling
The brain cells called astrocytes, and not just neurons, are sensitive to the substances called cannabinoids-the active chemicals in marijuana. view more (2008-03-27)
Cocaine-induced synaptic plasticity linked to persistent addictive behaviors
The persistent nature of addiction is its most devastating feature. Understanding the mechanism underlying this phenomenon is the key for designing efficient therapy. Two separate studies published by Cell Press is the August 14 issue of the journal Neuron identify specific cocaine-induced changes in dopamine (DA) neurons that play a pivotal role... view more... (2008-08-14)
Rare mutation causes early heart disease and metabolic syndrome
Yale School of Medicine researchers have identified a rare defect in a single gene that poses a substantial risk for metabolic syndrome and early heart disease, the leading cause of death worldwide. view more (2007-03-02)
Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
Angiogenesis inhibitors that block a tumor's development of an independent blood supply have been touted as effective cancer fighters that result in fewer side effects than traditional chemotherapy. view more (2007-08-24)
New method for detection of phosphoproteins reveals regulator of melanoma invasion
Scientists have developed a new approach for surveying phosphorylation, a process that is regulated by critical cell signaling pathways and regulates several key cellular signaling events. view more (2009-04-10)
Agent orange chemical, dioxin, attacks the mitochondria to cause cancer, says Penn research team
Researchers with the University of Pennsylvania School of Veterinary Medicine have demonstrated the process by which the cancer-causing chemical dioxin attacks the cellular machinery, disrupts normal cellular function and ultimately promotes tumor progression. view more (2007-12-18)
Estrogen curbs appetite in same way as the hormone leptin
Estrogen regulates the brain's energy metabolism in the same way as the hormone leptin, leading the way to a viable approach to tackling obesity in people resistant to leptin. view more (2007-01-04)
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