Hippo Signaling Current Events | Hippo Signaling News | 5
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Proteins that stop a major signaling pathway can also generate new proteins
Duke University Medical Center researchers have recently discovered that a crucial communications pathway in cells not only stops cells from making proteins, it also makes them go. view more (2008-04-25)
Toxic chemicals affect steroid hormones differently in humans and invertebrates
In a study with important consequences for studies on the effects of chemicals on steroid responses in humans, a team of French and American scientists, including Michael E. Baker, PhD, professor in UC San Diego's Department of Medicine, Division of Nephrology-Hypertension, have found that - contrary to earlier assumptions - enzymes used for the... view more... (2009-06-30)
Hippo ancestry disputed
Hippos spend lots of time in the water and now it turns out (or researchers argue), they are the closest living relative to whales. It also turns out, the two are swimming in a bit of controversy. view more (2009-03-19)
Ben-Gurion U. researchers identify how stressed fat tissue malfunctions
Ben-Gurion University of the Negev (BGU) researchers, in a collaboration with colleagues from the University of Leipzig, Germany, have identified a signaling pathway that is operational in intra-abdominal fat, the fat depot that is most strongly tied to obesity-related morbidity. view more (2009-07-15)
Enzyme's second messenger contributes to cell overgrowth
Scientists at the University of California, San Diego (UCSD) School of Medicine have uncovered a novel pathway by which hormones elevated in inflammation, cancer and cell injury act on cells to stimulate their growth. view more (2007-09-27)
Neuroscientists Show Insulin Receptor Signaling Regulates Structure and Function of Brain Circuits
A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated for the first time in living animals that insulin receptors in the brain can initiate signaling that regulates both the structure and function of neural circuits. view more (2008-06-19)
Signaling protein helps limit damage in heart attack, Jefferson scientists show
Scientists at the Center for Translational Medicine at Thomas Jefferson University in Philadelphia have shown that a specific signaling protein is crucial to protecting the heart and helping it to adapt during a heart attack. view more (2008-03-24)
Calorie restriction inhibits, obesity fuels development of epithelial cancers
A restricted-calorie diet inhibited the development of precancerous growths in a two-step model of skin cancer, reducing the activation of two signaling pathways known to contribute to cancer growth and development, researchers at The University of Texas M. D. Anderson Cancer Center report today at the American Association for Cancer Research... view more... (2008-04-15)
Stanford researchers investigate how plants adapt to climate
How many mouths does a plant need in order to survive? The answer changes depending on climate, and some of the decisions are made long before a new leaf sprouts. view more (2008-11-25)
Brain study may lead to improved epilepsy treatments
Using a rodent model of epilepsy, researchers found one of the body's own neurotransmitters released during seizures, glutamate, turns on a signaling pathway in the brain that increases production of a protein that could reduce medication entry into the brain. view more (2008-04-15)
Wnt signalling protein Dishevelled acts in the nucleus, not just in the cytoplasm
Researchers have identified that Dishevelled doesn't only function in the cytoplasm and at the cell membrane - it must also pass into the nucleus. A study published today in Journal of Biology reveals that Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, has to be localised in the nucleus to perform a key aspect of its... view more... (2005-02-11)
Plague agent helps UT Southwestern researchers find novel signaling system in cells
The bacterium that causes bubonic plague would seem unlikely to help medical scientists, but researchers at UT Southwestern Medical Center have harnessed it to uncover a new regulatory mechanism that inhibits the immune system. view more (2006-05-26)
Gene therapy inhibits epilepsy in animals
For the first time, researchers have inhibited the development of epilepsy after a brain insult in animals. By using gene therapy to modify signaling pathways in the brain, neurology researchers found that they could significantly reduce the development of epileptic seizures in rats. view more (2006-11-09)
Growth factor signals influence balance between normal growth and cancerous growth
New research from The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine deepens the understanding of how the growth hormone/IGF system is affected by another important actor: p53, the tumor suppressor gene that puts the brakes on cancer. view more (2006-11-10)
Penn researchers discover initial steps in the development of taste
Of the five senses, taste is one of the least understood, but now researchers at the University of Pennsylvania School of Medicine have come one step closer to understanding how the sense of taste develops. view more (2006-12-06)
Cancer therapy: A role for MAPK inhibitors combined with mTORC1 inhibitors
Nearly a decade ago, while it was being tested as an immunosuppressive agent to prevent organ rejection in transplant patients, the drug rapamycin was also discovered to have anti-tumor properties. Since then, several rapamycin analogs known as mTOR (mammalian target of rapamycin) inhibitors have been tested in clinical trials for the treatment of... view more... (2008-08-22)
Study unveils how West Nile virus evades immune defenses, points to vaccine development
West Nile virus evades the body's immune defenses by blocking immune signaling by a protein receptor, a finding that could pave the way for a vaccine to protect against North American strains of the virus. view more (2006-10-05)
Cilia: small organelles, big decisions
Johns Hopkins researchers say they have figured out how human and all animal cells tune in to a key signal, one that literally transmits the instructions that shape their final bodies. view more (2007-10-04)
Protein is Key to Embryonic Stem Cell Differentiation
Investigators at Burnham Institute for Medical Research (Burnham) have learned that a protein called Shp2 plays a critical role in the pathways that control decisions for differentiation or self-renewal in both human embryonic stem cells (hESCs) and mouse embryonic stem cells (mESCs). view more (2009-03-19)
Fate in fly sensory organ precursor cells could explain human immune disorder
Notch signaling helps determine the fate of a number of different cell types in a variety of organisms, including humans. In an article that appears in the current issue of Nature Cell Biology, researchers at Baylor College of Medicine report that a new finding about the Notch signaling pathway in sensory organ precursor cells in the fruit fly... view more... (2009-06-22)
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