Hippo Signaling Current Events | Hippo Signaling News | 8
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Study details hepatitis C ability to block immune system response
Hepatitis C virus (HCV) is a worldwide public health problem. The World Health Organization estimates that 170 million people worldwide are chronically infected and that between 3-4 million are newly infected annually. view more (2006-05-19)
Carvedilol shown to have unique characteristics among beta blockers
In a new study, researchers report that a class of heart medications called beta-blockers can have a helpful, or harmful, effect on the heart, depending on their molecular activity. view more (2009-11-23)
Vaporized viral vector shows promise in anti-cancer gene therapy
A new lung cancer therapy employing a vaporized viral vector to deliver a cancer-inhibiting molecule directly to lung tissue shows early promise in mouse trials, according to researchers at the Ministry of Education, Science and Technology in Korea. view more (2009-06-09)
New investigational treatment for bladder cancer, identified with Columbia-developed research model
A team of researchers, led by Columbia University Medical Center faculty, has identified a new investigational therapy for the treatment of bladder cancer. view more (2009-03-13)
Study sheds light on signaling mechanism in stem cells, cancer
UCSF scientists have illuminated a key step in a signaling pathway that helps orchestrate embryonic development. view more (2005-10-26)
Insulin's brain impact links drugs and diabetes
Insulin, long known as an important regulator of blood glucose levels, now has a newly appreciated role in the brain. view more (2007-10-17)
Oregon researchers discover a mechanism leading to cleft palate
By creating a genetic mutation in zebrafish, University of Oregon scientists say they've discovered a previously unknown mechanism for cleft palate, a common birth defect in humans that has challenged medical professionals for centuries. view more (2008-02-12)
Targeting the more lethal form of the cancer rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is an aggressive muscle cancer that mostly affects children. The most common forms of RMS are embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). view more (2009-05-26)
First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
In a paper being presented in two American Physiological Society sessions at Experimental Biology 2006, a joint Estonian-French team demonstrated "for the first time that mitochondria are able to induce nuclear deformation, suggesting that mitochondria may mechanically regulate nuclear function." view more (2006-04-03)
Gene discovery may shed light on kidney disease
In a finding that may have broader implications for understanding kidney disorders, genetics researchers at The Children's Hospital of Philadelphia have identified a second gene that gives rise to Alagille syndrome, a genetic developmental disease that affects multiple organs. view more (2006-08-01)
Molecular 'on/off switch' controls immune defenses against viruses
Much like flipping a light switch, the hepatitis C virus turns on human immune defenses upon entering the body but also turns off those defenses by manipulating interaction of key cellular proteins, UT Southwestern Medical Center researchers have found. view more (2006-12-26)
New discovery may improve treatment of one of the world's leading causes of blindness
An inflammatory eye condition that is one of the world's leading causes of blindness could be treated much more effectively and easily thanks to a new discovery here. view more (2007-10-01)
How can we know early who will benefit from tumor target therapy?
The precise tailoring of tumor target treatment for patients with cancer is an unmet challenge. The goal is to only administer treatments that have a high probability of being effective. view more (2007-11-26)
Crossed (Evolutionary) Signals?
What do humans and single-celled choanoflagellates have in common? More than you'd think. New research into the choanoflagellate genome shows these ancient organisms have similar levels of proteins that cells in more complex organisms, including humans, use to communicate with each other. view more (2008-07-02)
Zinc plays important role in brain circuitry
To the multitude of substances that regulate neuronal signaling in the brain and spinal cord add a new key player: zinc. By engineering a mouse with a mutation affecting a neuronal zinc target, researchers have demonstrated a central role for zinc in modulating signaling among the neurons. view more (2006-11-27)
New clue into how diet and exercise enhance longevity
The traditional prescriptions for a healthy life-sensible diet, exercise and weight control-extend life by reducing signaling through a specific pathway in the brain, according to Howard Hughes Medical Institute researchers who discovered the connection while studying long-lived mice. view more (2007-07-20)
Who gives stem cells their marching orders?
Researchers from the Swiss Institute for Experimental Cancer Research (ISREC) have shown that a single gene involved in embryonic development is responsible for two seemingly contradictory activities - maintaining stem cells after the embryo has implanted in the mother's uterus, and later providing cues to direct their differentiation in a... view more... (2006-09-06)
New findings show additional similarity between opiate and nicotine addiction
"That was good!" "Do it again." This is what the brain says when people use tobacco, as well as 'hard drugs' such as heroin. view more (2008-02-13)
Researchers identify target for therapeutic drugs to fight most common adult brain cancer
A research team at UT Southwestern Medical Center has discovered a cell-signaling mechanism instrumental in the most common brain cancer in adults. view more (2006-01-16)
Experimental approach may reverse rheumatoid arthritis and osteoporosis
Researchers have identified a mechanism that may keep a well known signaling molecule from eroding bone and inflaming joints, according to an early study published online today in the Journal of Clinical Investigation. view more (2009-09-22)
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