Histone Demethylase Current Events | Histone Demethylase News
|
|
|
Sort By:
Page Views | Date |
Stowers Institute's Workman Lab discovers novel histone demethylase protein complex
The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell. view more (2008-12-08)
Novel enzyme offers new look at gene regulation
Scientists at the University of North Carolina at Chapel Hill have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent. view more (2005-12-21)
Opening and closing the genome
At any given time, most of the roughly 30,000 genes that constitute the human genome are inactive, or repressed, closed to the cellular machinery that transcribes genes into the proteins of the body. view more (2007-02-26)
Shilatifard and colleagues identify a potential target for treatment of mixed lineage leukemia
Ali Shilatifard, Ph.D., Investigator, has identified a cellular factor that can reverse histone trimethylation caused by the trithorax gene, the Drosophila homologue of the human mixed lineage leukemia gene, MLL. MLL, which is found in translocations in a variety of hematological malignancies, is a histone H3K4 methyltransferase. view more (2007-03-12)
Oliguridylation-mediated histone mRNA decay
In the January 1st issue of G&D, Drs. Thomas Mullen and William Marzluff (UNC Chapel Hill) lend new insight into the degradation of mammalian histone mRNA. view more (2008-01-02)
The meiotic histone code
Dr. Terry Orr-Weaver and colleagues (MIT & Nagasaki University School of Medicine) present the first genetic analysis of the recently identified nucleosomal histone kinase, NHK-1. view more (2005-10-17)
ossible drug target for obesity treatment a no-brainer: UNC study
Scientists at the University of North Carolina at Chapel Hill School of Medicine have discovered a gene that when mutated causes obesity by dampening the body's ability to burn energy while leaving appetite unaffected. view more (2009-02-05)
Future therapies for stroke may block cell death
A new therapy to re-activate silenced genes in patients who suffer from neurodegenerative diseases or stroke is being developed by researchers at the University of Illinois at Chicago and Cornell University. view more (2007-06-14)
Linking DNA and histone methylation
In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes. view more (2007-04-30)
Delving deeper into the machinery of cocaine addiction
Researchers are now understanding in greater detail the molecular machinery underlying the short-term brain changes that produce the high of cocaine, as well as the longer-term changes behind addiction. Their findings offer hope for targeted drugs that can short-circuit that addiction machinery. view more (2005-10-20)
Study finds protein is required for human chromosome production
Scientists at the University of North Carolina at Chapel Hill School of Medicine have identified an elusive protein that performs a necessary step in the production of human chromosomes. view more (2005-10-13)
Proteasome inhibition affects epigenetic mechanisms
Alcohol consumption causes alteration in several cellular mechanisms, and leads to inflammation, apoptosis, immunoresponse defect, and fibrosis. view more (2009-02-19)
Epigenetic research uncovers new targets for modification enzymes
Enzymes regulating genetic expression can be just as important as the genome itself, increasing evidence shows. The expanding field of epigenetics focuses on the multiple influences on DNA and surrounding molecules that determine whether genes are turned on or off during development and disease processes. view more (2008-04-28)
Gerton Lab determines the composition of centromeric chromatin
The Stowers Institute's Gerton Lab has provided new evidence to clarify the structure of nucleosomes containing Cse4, a centromere-specific histone protein required for proper kinetochore function, which plays a critical role in the process of mitosis. The work, conducted in yeast cells, was published in the most recent issue of Molecular Cell. view more (2009-09-29)
Roles of DNA packaging protein revealed by Einstein scientists
Scientists at Albert Einstein College of Medicine of Yeshiva University have found that a class of chromatin proteins is crucial for maintaining the structure and function of chromosomes and the normal development of eukaryotic organisms. view more (2009-02-13)
New biomarkers for lupus found
A Wake Forest University School of Medicine team believes it has found biomarkers for lupus that also may play a role in causing the disease. view more (2006-11-13)
University of Minnesota researchers take new look at cellular suicide
Like a bodyguard turned traitor, a protein whose regular job is to help repair severed DNA molecules will, in some cases, join forces with another protein to do the opposite and chop the DNA to bits. view more (2006-07-07)
Scientists discover stage at which an embryonic cell is fated to become a stem cell
Cambridge scientists have discovered the stage at which some of the cells of a fertilised mammalian egg are fated to develop into stem cells and why this occurs. view more (2007-01-11)
Workman Lab characterizes novel regulator of chromosome function
The Stowers Institute's Workman Lab has shed new light on a novel histone acetyltransferase protein complex called ATAC. Acetyltransferases are enzymes that introduce a new acetyl functional group into histone proteins, a process by which all chromosome functions are controlled. view more (2008-03-11)
Gene-regulating enzyme is also a target for anti-depressive drugs
In 2005, professor Ramin Shiekhattar, Ph.D., at The Wistar Institute and his colleagues reported details about an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells. view more (2006-06-26)
|
|
|
|
Sort By:
Page Views | Date |
|
