Homologous Recombination Current Events | Homologous Recombination News
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NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development
A new study published online in Nature Immunology ahead of the June 2009 print issue has found that homologous immunoglobulin (lg) alleles pair up in the nucleus at stages that coincide with V(D)J recombination of the heavy and light chain (Igh and Igk) loci. view more (2009-05-22)
Human RecQ helicases, homologous recombination and genomic instability
Two independent papers in the December 1st issue of G&D detail how human RecQ helicases regulate homologous recombination and protect genome stability. view more (2007-11-15)
Enhanced DNA-repair mechanism can cause breast cancer
Although defects in the "breast cancer gene," BRCA1, have been known for years to increase the risk for breast cancer, exactly how it can lead to tumor growth has remained a mystery. view more (2007-10-15)
Centromeres cross over, a lot
Recombination at centromeres is higher than anywhere else on the chromosome, even though methyltransferases do their best to prevent it, say Jaco et al., as published in the June 16 issue of the Journal of Cell Biology. view more (2008-06-13)
The downside to diversification
Dr. Dale Ramsden and colleagues at UNC-Chapel Hill report in the June 15th issue of G&D on the potential contribution of V(D)J recombination to genomic instability and cancer formation. view more (2006-06-15)
Environmental triggers may promote human genetic variation
In this month's issue of the leading scientific journal Genome Research, scientists from Kyushu University report how environmentally damaged DNA may contribute to human genetic diversity. view more (2006-05-01)
Chromosomes dance and pair up on the nuclear membrane
Meiosis - the pairing and recombination of chromosomes, followed by segregation of half to each egg or sperm cell - is a major crossroads in all organisms reproducing sexually. view more (2009-11-16)
Zooming in on genetic shuffling
Genetic recombination, the process by which sexually reproducing organisms shuffle their genetic material when producing germ cells, leads to offspring with a new genetic make-up and influences the course of evolution. view more (2008-07-11)
The recombination of chromosomes: a controlled game of love and chance?
Sexual reproduction has many advantages - some most pleasurable - and probably leads to the long-term survival of the species concerned. During the formation of reproductive cells or gametes, sexual reproduction is accompanied by an exchange of genes between the two chromosomes inherited from the parents. Each individual arising from these gametes... view more... (2002-10-22)
Penn Researchers Identify First Sex Chromosome Gene Involved in Meiosis and Male Infertility
A team of scientists led by University of Pennsylvania veterinary researchers have identified a gene, TEX11, located on the X chromosome, which when disrupted in mice renders the males sterile and reduces female fecundity. This is the first study of the genetic causes of infertility that links a particular sex chromosome meiosis-specific gene to... view more... (2008-03-17)
Scientists develop new treatment for hereditary breast cancer
Researchers at the University of Sheffield, funded by Yorkshire Cancer Research, have discovered a new way of treating and preventing hereditary breast cancer. The latest finding describes how the use of a chemical inhibitor can specifically kill tumour cells, which have a defect in the gene causing hereditary breast cancer. This new treatment... view more... (2005-04-11)
New mechanism discovered for DNA recombination and repair
A biochemistry research team led by Dr. Andrew H.-J. Wang and Dr. Ting-Fang Wang at the Institute of Biological Chemistry, Academia Sinica(IBCAS), has discovered that the RecA family recombinases function as a new type of rotary motor proteins to repair DNA damages. view more (2007-09-12)
Gene for neat repair of DNA discovered
Researchers from the Erasmus University in Rotterdam have demonstrated that a gene helps in the neat repair of DNA. Without this gene the body would repair damaged DNA in a careless manner more often. This causes new damage, which can lead to cancer. The careless repair of damaged DNA can cause mutations and can result in cancer. Cell biologists... view more... (2002-01-24)
Estimation of isolation times in the Drosophila simulans complex
The Drosophila simulans species complex continues to serve as an important model system for the study of new species formation. The complex is comprised of the cosmopolitan species, D. simulans, and two island endemics, D. mauritiana and D. sechellia. view more (2008-06-26)
New information about DNA repair mechanism could lead to better cancer drugs
Researchers at Washington University School of Medicine in St. Louis have shed new light on a process that fixes breaks in the genetic material of the body's cells. view more (2009-07-17)
Hidden structure revealed in characteristics of transistor laser
The transistor laser, invented by scientists at the University of Illinois at Urbana-Champaign, has been full of surprises. view more (2006-04-06)
HIV-1 : RECOMBINATION BETWEEN TWO STRAINSFROM WIDELY DISTANT GROUPS
Scientists have known for a long time that the AIDS virus is genotypically highly variable. Two main types of the virus exist: HIV-1 and HIV-2. HIV-1, the most widespread throughout the world, can be divided into three groups (M, N and O) each of which has different genetic characteristics. Within group M, which gathers together the most frequent... view more... (2000-03-09)
Mitochondrial genes move to the nucleus
Why mitochondrial genes ditch their cushy haploid environs to take up residence in a large and chaotic nucleus has long stumped evolutionary biologists, but Indiana University Bloomington scientists report in this week's Science that they've uncovered an important clue in flowering plants. view more (2007-03-23)
Surprising new insights into the repair strategies of DNA
A microscopic single-celled organism, adapted to survive in some of the harshest environments on earth, could help scientists gain a better understanding of how cancer cells behave. view more (2009-07-16)
Scientists break light modulation speed record -- twice
Researchers have constructed a light-emitting transistor that has set a new record with a signal-processing modulation speed of 4.3 gigahertz, breaking the previous record of 1.7 gigahertz held by a light-emitting diode. view more (2009-06-16)
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