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High-dose Interferon Beta-1B On Alternate Days Could Offer Increased Clinical Benefit For People With Multiple Sclerosis (p 1453)
A study published in this week's issue of THE LANCET suggests that high-dose interferon beta-1b administered every other day is more effective than interferon beta-1a once a week for people with multiple sclerosis (MS). There are three interferon beta therapies known to be effective in reducing MS symptoms: interferon beta-1a 30 mcg administered... view more... (2002-04-24)
Is transforming growth factor-beta involved in intestinal wound healing?
Migration of colonic lamina propria fibroblasts (CLPF) plays an important role during the progression of fibrosis and fistulae in Crohn's disease. Transforming growth factor- beta (TGF- beta) is involved in the regulation of cell migration, cell differentiation, extracellular matrix deposition, and immune responses. view more (2009-03-31)
Joslin-led study uncovers role of appetite hormone MCH in insulin production
A new Joslin Diabetes Center-led study has shown conclusively that a neuropeptide, melanin concentrating hormone (MCH), found in the brain and known for its role in increasing appetite in people, plays a role in the growth of insulin-producing beta cells and the secretion of insulin. view more (2007-01-29)
Compounds that trigger beta cell replication identified by JDRF funded researchers
Researchers at the Genomics Institute of the Novartis Research Foundation (GNF) have identified a set of compounds that can trigger the proliferation of insulin-producing cells in the pancreas, using sophisticated high-throughput screening techniques. view more (2009-02-26)
Mouse gene suppresses Alzheimer's plaques and tangles
Investigators at Burnham Institute for Medical Research (Burnham) and colleagues have identified a novel mouse gene (Rps23r1) that reduces the accumulation of two toxic proteins that are major players in Alzheimer's disease: amyloid beta and tau. view more (2009-11-12)
White blood cells are picky about sugar
Biology textbooks are blunt-neutrophils are mindless killers. These white blood cells patrol the body and guard against infection by bacteria and fungi, identifying and destroying any invaders that cross their path. view more (2007-07-12)
Circulating fats kill transplanted pancreas cells, study shows
Dietary restrictions or other strategies that limit fat formation might make pancreatic cell transplants more effective, UT Southwestern Medical Center researchers report. view more (2007-08-28)
Scientists isolate chemical in curry that may help immune system clear plaques found in Alzheimer's
Researchers isolated bisdemethoxycurcumin, the active ingredient of curcuminoids - a natural substance found in turmeric root - that may help boost the immune system in clearing amyloid beta, a peptide that forms the plaques found in Alzheimer's disease. view more (2007-07-17)
Pumpkin: A fairytale end to insulin injections?
Compounds found in pumpkin could potentially replace or at least drastically reduce the daily insulin injections that so many diabetics currently have to endure. view more (2007-07-09)
Treatment-induced growth factor causes cancer progression
In advanced cancer, anti-tumor therapies often work only partially or not at all, and tumors progress following treatment. view more (2007-04-06)
Different forms of amyloid beta in Alzheimer's disease harm neurons in different ways
Researchers at UC Irvine have shown that different forms of amyloid beta lead to neural damage in different ways, leading to an increasingly complex view of amyloid toxicity in the Alzheimer brain. view more (2006-06-01)
CHEO RI study uses sophisticated genetic engineering to improve insulin-producing beta cells
One of the biggest mysteries about diabetes is why specialized cells in the pancreas stop secreting insulin, which the body needs in order to store glucose from food. view more (2009-10-08)
Discovery of new signal pathway important to diabetes research
Scientists at Karolinska Institutet in Sweden and Miami University have discovered that cells in the pancreas cooperate - signal - in a way hitherto unknown. The discovery can eventually be of significance to the treatment of diabetes. view more (2008-06-05)
Joslin study indicates insulin receptors play a critical role in promoting islet growth
A new Joslin-led study has identified the insulin receptor as an important protein that promotes islet cell growth in mice whose bodies are unable to use insulin properly, or are insulin resistant, a precursor to type 2 diabetes. view more (2007-04-03)
Gladstone scientists uncover potential mechanism of memory loss in Alzheimer's disease
Researchers at the Gladstone Institute of Neurological Disease (GIND) and Baylor College of Medicine have discovered a mechanism by which the protein Amyloid-beta(AB) may impair neurological functions in Alzheimer's disease. view more (2007-09-06)
Researchers challenge previous findings regarding widely used asthma treatment
A new study published recently in The Lancet reveals that one of the most commonly used asthma medicines -- long-acting beta-agonists -- may not be associated with adverse events in people based on their genotype (gene variation), as previous studies had shown. view more (2008-01-11)
Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
UT Southwestern Medical Center researchers have genetically engineered a laboratory mouse in which pancreatic beta cells can regenerate after being induced to die. The new animal model's regenerative ability may provide future insights into improved treatments of diabetes, which affects millions of Americans. view more (2008-06-02)
Penn study points to new direction for pancreas cell regeneration
Replacing faulty or missing cells with new insulin-making cells has been the object of diabetes research for the last decade. Past studies in tissue culture have suggested that one type of pancreas cell could be coaxed to transform into insulin-producing islet cells. view more (2007-04-04)
Stem cell breakthrough offers diabetes hope
Scientists have discovered a new technique for turning embryonic stem cells into insulin-producing pancreatic tissue in what could prove a significant breakthrough in the quest to find new treatments for diabetes. view more (2008-04-03)
Government money for multiple sclerosis patients could be better spent
The National Institute for Clinical Excellence (NICE) has announced that neither interferon beta nor glatiramer can be recommended for multiple sclerosis in the NHS. However, the UK government plans to make these drugs available through a risk sharing scheme, despite limited evidence of clinical and cost effectiveness. Researchers in this week's... view more... (2003-02-12)
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