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New study reveals signaling pathways required for expansion of pancreas stem cells
IDDM, which used to be referred to as Type 1 diabetes, results from selective destruction of insulin-producing pancreatic islet beta cells by the body's immune system. view more (2006-05-17)
U.Va. Scientists Identify 'Missing Link' in Process Leading to Alzheimer's Disease
Scientists at the University of Virginia have identified what appears to be a major missing link in the process that destroys nerve cells in Alzheimer's disease, an incurable disease that slowly destroys memory and cognitive abilities. view more (2007-02-08)
New cause of critical illness hypeglycemia identified
The endocrinologic basis of pediatric critical illness hypergylcemia (CIH) differs depending on the disease processes. Researchers writing in BioMed Central's open access journal Critical Care describe how both peripheral insulin resistance and primary beta-cell dysfunction can cause CIH in children. view more (2009-02-26)
The Definitive Beta-blocker For Heart Failure? (pp 2, 7, 14)
Results of a European study in this week's issue of THE LANCET suggest that the beta-blocker carvedilol offers substantial survival benefit compared with another widely-used beta blocker for the treatment of chronic heart failure. Beta blockers reduce death in patients who are also taking diuretics and ACE inhibitors for chronic heart failure. In... view more... (2003-07-02)
Lost in the labyrinth
Blood cells have limited lifespans, which means that they must be continually replaced by calling up reserves, and turning these into the blood cell types needed by the body. view more (2006-09-05)
Wnt signalling protein Dishevelled acts in the nucleus, not just in the cytoplasm
Researchers have identified that Dishevelled doesn't only function in the cytoplasm and at the cell membrane - it must also pass into the nucleus. A study published today in Journal of Biology reveals that Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, has to be localised in the nucleus to perform a key aspect of its... view more... (2005-02-11)
Research yields potential target for cancer, wound healing and fibrosis
Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists design novel approaches to control wound healing and fight diseases such as cancer and fibrosis. view more (2009-03-19)
Deadly infectious entity of prions discovered
The mysterious, highly infectious prions, which cause the severe destruction of the brain that characterizes "mad cow disease" and several human brain degenerative disorders, can be rendered harmless in the laboratory by a slight alternation of the three-dimensional conformation or shape of the prion protein's structure. view more (2005-06-10)
Further evidence showing treatment benefits of beta interferon for multiple sclerosis (pp 1463, 1489)
Results of a European study in this week's issue of THE LANCET provide further evidence that patients with early symptoms of multiple sclerosis given a weekly injection with interferon beta are less likely to progress to full clinical disease after two years follow-up. The study showed that the drug reduced patients' loss of brain tissue compared... view more... (2004-10-20)
Atrial fibrillation linked to increased hospitalization in heart failure patients
Patients with atrial fibrillation, common in those with advanced chronic heart failure, have an increased risk of hospitalization due to heart failure. view more (2009-07-07)
Rethinking Alzheimer's disease and its treatment targets
The standard explanation for what causes Alzheimer's is known as the amyloid hypothesis, which posits that the disease results from of an accumulation of the peptide amyloid beta, the toxic protein fragments that deposit in the brain and become the sticky plaques that have defined Alzheimer's for more than 100 years. view more (2009-09-23)
New strategy for protecting brain against Alzheimer's disease: Enhancing the innate immune system
The human body has its own defense against brain aging: the innate immune system, which helps to clean the brain of amyloid-beta waste products. However, UCLA researchers discovered that some patients with Alzheimer's disease have an immune defect making it difficult to clean away these wastes. view more (2005-06-10)
Beating the aging process naturally
The fight against aging has received a scientific boost thanks to an innovative study done in part by a University of Alberta spin-off company-research that dispels a hard-held belief about the natural ingredient, beta glucan. view more (2005-09-30)
A surprise 'spark' for pre-cancerous colon polyps
Researchers at Huntsman Cancer Institute (HCI) at the University of Utah studied the events leading to colon cancer and found that an unexpected protein serves as the "spark" that triggers formation of colon polyps, the precursors to cancerous tumors. view more (2009-05-15)
Scientists identify new strategy for preventing acute and chronic brain disease
Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that reducing levels of the protein tau can prevent seizures and neurological deficits related to Alzheimer's disease. view more (2007-05-04)
Protein that regulates aging may provide key to new diabetes therapies
Opening the possibility of new therapies for type 2 diabetes, researchers at Washington University School of Medicine in St. Louis have found that a protein called Sirt1 enhances the secretion of insulin in mice and allows them to better control blood glucose levels. view more (2005-08-19)
Gas-blockers might slow down Alzheimer's disease
A noxious gas speeds up brain degeneration in Alzheimer's disease, according to a study in the November 7 issue of The Journal of Experimental Medicine. view more (2005-10-31)
Researchers Reveal Possibility of Separating Anticancer Properties of Vitamin D
At the right dose, vitamin D is important for bone development and may help protect against the development of several cancers, particularly colorectal cancer. view more (2006-03-20)
Alzheimer's-associated enzyme can disrupt neural activity in the brain
An enzyme involved in the formation of the amyloid-beta protein associated with Alzheimer's disease can also alter the mechanism by which signals are transmitted between brain cells, the disruption of which can cause seizures. view more (2007-06-18)
New target for heart failure therapy identified
A novel signaling pathway plays a significant role in the production of aldosterone, a hormone that promotes heart failure after a myocardial infarction, according to a study conducted by Thomas Jefferson University researchers. view more (2009-03-17)
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