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NO ADDITIONAL BENEFIT FROM ORAL INSULIN FOR PEOPLE WITH TYPE 1 DIABETES (pp 526, 545)
Research published in this week's issue of THE LANCET shows that oral insulin does not slow the destruction of insulin-secreting cells in people with type 1 diabetes when taken in addition to intravenous insulin therapy. Oral administration of insulin can slow the progression of b-cell destruction in non-obese diabetic mice. Lucy Chaillous and... view more... (2000-08-09)
Is inhaled insulin delivery still a possibility? Why has it been a commercial failure?
The commercial failure of Exubera® (Pfizer, New York, NY), the first inhaled insulin product to come to market, led other companies such as Eli Lilly-Alkermes to halt studies of similar drug delivery in development intended to compete for a share of the lucrative diabetes market. view more (2009-09-24)
Eight new genes linked to diabetes; the understanding of a financial and health monster
Eight genes, normally associated with normal pancreatic functions, are linked with susceptibility to diabetes Type 2 reports a team of investigators in the last issue of the PLoS Biology Journal. In'™s Barroso and colleagues at the University of Cambridge, United Kingdom studied 71 genes on more than 2000 individuals, trying to correlate... view more... (2003-11-28)
Self-monitoring of blood glucose
Diabetes patients should always control their own blood sugar values if this leads to improvements in their treatment. view more (2009-09-29)
Metformin increases pathologic complete response rates in breast cancer patients with diabetes
Metformin, the common first-line drug for type 2 diabetes, may be effective in increasing pathologic complete response rates in diabetic women with early stage breast cancer who took the drug during chemotherapy prior to having surgery, paving the way for further research of the drug as a potential cancer therapy, according to researchers at The... view more... (2008-06-03)
Pure insulin-producing cells produced in mouse
Singapore researchers have developed an unlimited number of pure insulin-producing cells from mouse embryonic stem cells (ESCs). view more (2008-11-21)
Testing for insulin without the pitter-patter of little feet
In the January issue of Clinical Biochemistry, scientists and physicians with the Physicians Committee for Responsible Medicine (PCRM) outline the method used to develop a cruelty-free ELISA for human insulin that uses monoclonal antibodies produced by cells cultured in an animal-serum-free medium. view more (2007-01-31)
If the diabetes has a direct carcinogenetic effect?
The association of DM2 with solid tumors, and particularly with HCC, has been long suspected and several studies have reported increased mortality rates for neoplastic diseases in patients with DM2. view more (2008-10-29)
Low-carb diet better than low-fat diet at improving metabolic syndrome
Diabetes and cardiovascular disease associated with it. In an article published today in the open access journal Nutrition & Metabolism, Jeff Volek and Richard Feinman review the literature and show that the features of metabolic syndrome are precisely those that are improved by reducing carbohydrates in the diet. view more (2005-11-16)
Insect Resistance to Bt Crops can be Predicted, Monitored, and Managed
Since 1996, crop plants genetically modified to produce bacterial proteins that are toxic to certain insects, yet safe for people, have been planted on more than 200 million hectares worldwide. view more (2009-11-24)
Gardenia fruit compound starting point for diabetes therapy
A Gardenia fruit extract traditionally used in Chinese medicine to treat the symptoms of type 2 diabetes does indeed contain a chemical that reverses some of the pancreatic dysfunctions that underlie the disease. view more (2006-06-07)
Bypassing the insulin highway
An immune cell known as a neutrophil releases a protein that can suppress glucose production in the liver -without targeting insulin, researchers have found. view more (2008-04-28)
European league-tables for antibiotic resistance revealed
Tests of antibiotic resistance in cattle have revealed stark variation across thirteen European countries. The results, published today in BioMed Central's open-access journal Acta Veterinaria Scandinavica, show that major differences were apparent in the occurrence of resistance between countries and between the different antimicrobial agents... view more... (2008-07-08)
Study suggests use of stem cell transplantation is beneficial treatment of type 1 diabetes
A therapy that includes stem cell transplantation induced extended insulin independence in patients with type 1 diabetes mellitus. view more (2007-04-11)
Insulin analogue glargine possibly increases cancer risk
The risk of cancer possibly increases if patients with diabetes use the long-acting insulin analogue glargine instead of human insulin. view more (2009-06-29)
Insulin research builds on Nobel Laureate's work
Scientists have seen for the first time a key step in the complex molecular processes whereby pancreas cells release insulin into the bloodstream. view more (2006-05-08)
Early Promise Of New Treatment For Type 2 Diabetes (p 824)
Authors of a pilot study in this week's issue of THE LANCET suggest that a naturally occurring intestinal hormone could be beneficial for the future treatment of type 2 diabetes. Type 2 diabetes affects an estimated 10% of adults over 60 years of age, and has recently been reported in teenage children. Treatment for the disorder usually includes... view more... (2002-03-06)
What are the characteristics of clarithromycin-resistant Helicobacter pylori?
Clarithromycin is currently one of the antibiotics used for eradication of Helicobacter pylori. However, reports of H. pylori resistance to this antibiotic are increasing worldwide. view more (2009-07-16)
Severe sleep apnea may be a risk factor for liver damage
Many patients with obstructive sleep apnea (OSA) are obese and therefore at risk of having fatty liver, a condition in which fat accumulates in the liver cells. But the link between OSA and liver injury independent of weight has yet to be examined. view more (2005-05-25)
Pluronic L-81 is a potential anti-diabetic drug?
Pluronic surfactants are synthetic copolymers based on ethylene oxide and propylene oxide. view more (2009-07-08)
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