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Immunologists identify biochemical signals that help immune cells remember how to fight infection
Immunology researchers at UT Southwestern Medical Center have discovered how two biochemical signals play unique roles in promoting the development of a group of immune cells employed as tactical assassins. view more (2009-05-29)
Interferon as long-term treatment for hepatitis C not effective, report HALT-C researchers
Use of the drug interferon as a long-term maintenance strategy to slow the progression of liver disease associated with the hepatitis C virus is ineffective, UT Southwestern Medical Center researchers and their colleagues from nine other institutions have found in a multicenter study. view more (2008-12-05)
Interferon does not slow or stop hepatitis C from worsening, study finds
Interferon does not slow or halt the progression of chronic hepatitis C and advanced liver disease in patients who haven't responded to previous attempts to eradicate the disease, a national study in which the Saint Louis University School of Medicine participated has found. view more (2007-11-09)
UT researcher: Interferon alpha can delay full onset of type I diabetes
A low dose of oral interferon alpha shows promise in preserving beta cell function for patients with newly diagnosed type 1 diabetes, or juvenile diabetes. view more (2009-07-01)
Leukemia drug proves safe and effective over the long term
The drug imatinib mesylate, more commonly known as Gleevec, proves safe and effective over the long term in patients with an advanced form of chronic myeloid leukemia (CML), according to a study prepublished online in Blood, the official journal of the American Society of Hematology. view more (2007-11-08)
Dual-drug therapy targets one colon cancer gene
Johns Hopkins Kimmel Cancer Center scientists have found that interferon, used for 30 years to treat blood cancers, multiple sclerosis and hepatitis, selectively kills colon cancer cells when combined with another standard chemotherapy agent. view more (2005-08-18)
Sounding the alarm for infections: EMBL researchers discover rapid-response, interferon-producing cells
Nearly fifty years ago, researchers discovered that when cells in laboratory cultures are infected by a virus, they secrete a substance that protects other cells from infection. In 1957 Alick Issaks and Jean-Jacques Lindenmann traced this effect to a protein called interferon, a molecule now known to play a key role in the immune system. Human and... view more... (2002-02-15)
Study shows positive findings in treating patients with advanced hepatitis C
The hepatitis C therapy peginterferon alfa-2b, when given as low-dose maintenance therapy, can prevent disease progression in certain patients who failed previous interferon-based hepatitis C therapies and have advanced liver disease, according to findings from a large, four-year study presented today at the 43rd annual meeting of the European... view more... (2008-04-25)
Researchers identify new anti-tumor gene
Researchers from Virginia Commonwealth University have identified a new anti-tumor gene called SARI that can interact with and suppress a key protein that is overexpressed in 90 percent of human cancers. The discovery could one day lead to an effective gene therapy for cancer. view more (2008-12-17)
A new step towards an AIDS vaccine
Progressive disease after HIV infection is inversely correlated with the presence of plasmacytoid dendritic cells (pDCs), a subset of the dendritic cell family and the major producers of type 1 interferon in the body. view more (2005-10-14)
Using math to understand hep. C: Patterns paint picture of who will respond to treatment
Genetic patterns are like the tea leaves in the bottom of a cup for predicting which patients are likely to respond to medical therapy for life-threatening viruses such as hepatitis C, Saint Louis University researchers have discovered. view more (2008-12-23)
MS patients not receiving medications to slow disease progression, research shows
Neurologists at Wake Forest University Baptist Medical Center have found that many patients diagnosed with multiple sclerosis (MS) are not taking or being prescribed drugs approved to treat the disease. view more (2007-04-17)
Research Reveals Inner Workings of Immune System "Thermostat"
When bacteria, viruses or parasites attack, immune system cells unleash the soldiers. These "hot" protein compounds kill invaders - but also trigger inflammation, which, if unchecked, can destroy tissue, induce shock and kill the host. view more (2006-08-21)
New approach to gene therapy may shrink brain tumors, prevent their spread
Massachusetts General Hospital (MGH) researchers are investigating a new approach to gene therapy for brain tumors - delivering a cancer-fighting gene to normal brain tissue around the tumor to keep it from spreading. view more (2008-09-26)
New blood tests for TB show exposure to disease while tuberculin skin tests do not
Two new interferon-gamma blood test assays to detect latent tuberculosis infection (LTBI) showed customers were exposed to a supermarket employee in Holland who had smear-positive tuberculosis, while traditional tuberculin skin tests (TST) did not, according to a large contact study. view more (2007-03-15)
Gene expression profiling of dengue virus infection in cell lines and patients
Researchers at the Novartis Institute for Tropical Diseases and the Genome Institute of Singapore have identified new host genes associated with dengue virus infection, which may open new avenues to developing a drug to treat the disease. view more (2007-11-07)
May hepatic granulomas be part of the histological spectrum of chronic hepatitis C?
While older large series of patients with hepatic granulomas have found sarcoidosis and tuberculosis to be the most common causes of hepatic granulomas, recent works have noted some patients with chronic hepatic C and hepatic granulomas and no other obvious associations. view more (2008-12-29)
Mathematical model identifies genes which battle hepatitis C
Joint research by Dr. Leonid Brodsky, of the Institute of Evolution of the University of Haifa, and Dr. Milton Taylor, of Indiana University, led to the discovery of a mathematical method which can identify which genes in our bodies conduct the battle against the various viruses that attack us. view more (2007-07-20)
Promising Drug Combination May Help Those with Ocular Melanoma that has Spread
A combination of two drugs shows promise in treating a rare and therapy-resistant type of melanoma that originates in the eye and spreads to other organs, according to a new study led by Duke University Comprehensive Cancer Center researchers. view more (2007-09-05)
Mount Sinai launches combination therapy trial to treat Relapsing-Remitting Multiple Sclerosis
Mount Sinai School of Medicine is the Clinical Coordinating Center for the first study to assess the effectiveness of combining two FDA approved medications as initial treatment for people with Relapsing Remitting Multiple Sclerosis view more (2006-04-12)
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