Kinase Activity Current Events | Kinase Activity News
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Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. view more (2009-06-19)
Researchers report the cloning of a key group of human genes, the protein kinases
Although the human genome has been sequenced, research into mechanism of action of genes has been hampered by the fact that most human genes have not been isolated. This is true for even the most common class of cancer-associated genes, the protein kinases, which mediate the majority of signaling events in cells by phosphorylating and modulating... view more... (2008-05-05)
Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
Drugs that block the activity of an enzyme might hold a key to treating chronic and severe disorders such as certain forms of constipation, hemorrhoids, anal fissures, Hirschsprung's disease and other similar gastrointestinal problems. view more (2006-07-19)
Scientists uncover mode of action of enzyme linked with several types of cancer
Scientists at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication. view more (2009-06-04)
Unexpected role: EGFR protects cancer cells from starving
A growth factor receptor found abundantly on the surface of cancer cells and long known to fuel cancer growth also protects tumor cells from starvation by a newly identified mechanism. view more (2008-05-06)
Unique dual target specificity of kinase inhibitor key for success against cancer
Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. view more (2006-05-16)
Mutation database helps personalized treatment of lung cancer
A groundbreaking free tool to help oncologists choose the best therapies for patients with non-small-cell lung cancer has been launched this week by scientists at the 1st European Lung Cancer Conference jointly organized by the European Society for Medical Oncology (ESMO) and the International Association for the Study of Lung Cancer (IASLC) in... view more... (2008-04-25)
The meiotic histone code
Dr. Terry Orr-Weaver and colleagues (MIT & Nagasaki University School of Medicine) present the first genetic analysis of the recently identified nucleosomal histone kinase, NHK-1. view more (2005-10-17)
Enzyme doesn't act alone in atrial fibrillation
An overactive enzyme is behind a leaky calcium channel that plays a role in the development of atrial fibrillation, which is the most common cardiac arrhythmia that is responsible for a third of all strokes. view more (2009-06-18)
Structure of key cancer drug target identified
Researchers from Monash's Department of Biochemistry and Molecular Biology have determined the structure of the protein JAK2 kinase, a discovery with huge implications for the design and development of new cancer drugs. view more (2005-10-26)
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site
Synopsis: Two papers from Woods and colleagues describe novel roles for members of the dual specificity tyrosine phosphorylated and regulated kinase (DYRK) family. In one, DYRK1A is shown to phosphorylate a novel site in the transcription factor FKHR (a forkhead protein) regulating its nuclear presence and transcriptional activity. In the second... view more... (2001-04-24)
UCSD study reveals the regulatory mechanism of key enzyme
Research conducted at the University of California, San Diego (UCSD) School of Medicine has shed new light on the structure and function of one of the key proteins in all mammalian cells, protein kinase A (PKA), an enzyme which plays an essential role in memory formation, communication between nerve cells, and cardiac function. view more (2007-09-21)
Stopping unwanted cell death: Implications for drug discovery
Research published in Nature Chemical Biology reveals that three specific inhibitors of a cell death pathway, termed necroptosis, all target and inhibit RIP1 kinase, a protein that can direct cells into necrosis. view more (2008-04-14)
Scientists uncover Ebola cell-invasion strategy
University of Texas Medical Branch at Galveston researchers have discovered a key biochemical link in the process by which the Ebola Zaire virus infects cells - a critical step to finding a way to treat the deadly disease produced by the virus. view more (2008-09-04)
UCL study shows beans beat cancer
Scientists have discovered a new and potent anti-cancer compound in everyday food. The collaborative study led by UCL (University College London) shows that the compound-inositol pentakisphosphate-found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour growth. view more (2005-09-16)
E. coli persists against antibiotics through HipA-induced dormancy
Bacteria hunker down and survive antibiotic attack when a protein flips a chemical switch that throws them into a dormant state until treatment abates, researchers at The University of Texas M. D. Anderson Cancer Center report in the Jan.16 edition of Science. view more (2009-01-16)
Making sense of the human genome: researchers characterize a crucial family of signaling proteins in the human genome
In this month's Genome Biology, Mitch Kostich and colleagues from the Schering-Plough Research Institute (NJ, USA) have identified and mapped an important group of molecules known as protein kinases. These molecules are central to the communication of information both within and between cells, in a process known as cell signaling. Defective... view more... (2002-08-23)
Estrogen protects liver after traumatic injury
Researchers have identified the receptor pathway used by estrogen to decrease liver injury after trauma and hemorrhage. view more (2007-04-02)
MIT researchers unravel bacteria communication pathways
MIT researchers have figured out how bacteria ensure that they respond correctly to hundreds of incoming signals from their environment. view more (2008-06-13)
First report of cancer drug Gleevec as new target therapy for pulmonary hypertension
Gleevec (Imatinib) is a representative of the newest generation of cancer drugs. The substance conveys its potent anti-proliferative effect by selectively supressing the tyrosine kinase pathway. view more (2005-09-30)
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