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Battle of the bulge: Low leptin levels undermine successful weight loss
Individuals who are obese are at increased risk of many diseases, including type 2 diabetes and heart disease. As 75%-95% of previously obese individuals regain their lost weight, many researchers are interested in developing treatments to help individuals maintain their weight loss.   view more (2008-06-23)

Blockade of fat hormone helps halt and heal multiple sclerosis
Italian researchers have found that blockade of the hormone leptin, which is primarily produced in fats cells, has beneficial effects on the induction and progression of experimental autoimmune encephalomyelitis (EAE) in mice - the animal model of human multiple sclerosis (MS).   view more (2006-01-13)

Asthma risk increased in women with high levels of fat tissue inflammatory protein
Women with high levels of an inflammatory protein produced by fat tissue are at significantly increased risk of asthma, finds research in published ahead of print in Thorax.   view more (2006-03-15)

New key brain target of fat hormone
Researchers have identified a new area of the brain that responds to the fat hormone leptin in regulating body weight and energy expenditure.   view more (2006-01-19)

Estrogen curbs appetite in same way as the hormone leptin
Estrogen regulates the brain's energy metabolism in the same way as the hormone leptin, leading the way to a viable approach to tackling obesity in people resistant to leptin.   view more (2007-01-04)

Obesity-related hormone is higher in children with Down syndrome
Children with Down syndrome are more likely than their unaffected siblings to have higher levels of a hormone associated with obesity, according to pediatric researchers.   view more (2007-10-29)

A link between obesity and memory? Saint Louis University research makes the connection
Scientists have wondered why obese patients who have diabetes also may have problems with their long-term memory. New Saint Louis University research in this month's Peptides provides a clue.   view more (2006-06-15)

Mutant Protein Developed By Hebrew University Scientists
A unique technique for neutralizing the action of the leptin protein in humans and animals - thereby providing a means for controlling and better understanding of leptin function, including its role in unwanted cell growth -- has been developed by researchers at the Hebrew University of Jerusalem.   view more (2005-03-16)

Brain circuits that control hunger identified
Researchers at UCLA have determined the brain circuits involved in hunger that are influenced by a hormone called leptin. In previous clinical trials, supplementation of leptin, the signaling molecule produced by fat cells, produced moderate weight loss in some obese patients, purportedly by... view more (2007-10-30)

Adaptive functional evolution of leptin in cold-adaptive pika family
Researchers at the Northwest Institute of Plateau Biology, Chinese Academy of Sciences have put forward the viewpoint for the first time that adaptive functional evolution may occur in the leptin protein of the pika (Ochotona) family, a typical cold-adaptive mammal.   view more (2008-01-23)

Overproducing leptin receptors in fat cells may be key to halting weight gain
A new study by researchers at UT Southwestern Medical Center suggests that when fat cells increase in size - as they do during the development of obesity - the cells progressively lose receptors for the hormone leptin, a powerful stimulus for fat burning.   view more (2005-12-01)

Leptin has powerful effect on reward center in the brain
Leptin, a hormone critical for normal food intake and metabolism, exerts a strong effect on appetite by acting in the mid-brain region as well as in the hypothalamus.   view more (2006-09-29)

Lean for life
Infant formula and other baby foods that provide permanent protection from obesity and diabetes into adulthood could be on shop shelves soon, reports Lisa Melton in Chemistry & Industry, the magazine of the SCI.   view more (2007-04-23)

Joslin researchers uncover potential role of leptin in diabetes
A new Joslin-led study has shown that leptin, a hormone known mainly for regulating appetite control and energy metabolism, plays a major role in islet cell growth and insulin secretion.   view more (2007-10-02)

Researchers show how obesity causes breakdown in system which regulates appetite and weight
New research led by scientists at the Oregon National Primate Research Center demonstrates how obesity causes the breakdown of a brain system that regulates appetite.   view more (2007-03-07)

Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates.   view more (2007-04-30)

Combining exercise with hormone could prevent weight gain
Once heralded as a promising obesity treatment, the hormone leptin lost its fat-fighting luster when scientists discovered overweight patients were resistant to its effects. But pairing leptin with just a minor amount of exercise seems to revive the hormone's ability to fight fat again, University... view more (2008-05-28)

Research provides clues to obesity's cause and hints of new approach for curbing appetite
Hot fudge sundaes and french fries aside, new research suggests obesity is due at least in part to an attraction between leptin, the hormone that signals the brain when to stop eating, and a protein more recently associated with heart disease.   view more (2006-04-10)

Weight control protein may yield antiobesity drugs
A weight control protein with a key role in the brain's ability to monitor body fat content may yield new approaches for treating obesity and type 2 diabetes, according to a new report in the August issue of Cell Metabolism.   view more (2005-08-17)

Leptin found to control appetite and limb development in frogs
Leptin, the hormone secreted by fat cells that plays an important role in food intake, has been described for the first time in a cold-blooded vertebrate, the South African clawed frog Xenopus.   view more (2006-06-13)

High risk of breast cancer associated with genetic variation in leptin and its receptor
Individuals with either of two genetic variations that lead to high serum levels of the cytokine leptin and to overexpression of leptin in fatty tissue, are more at risk of developing breast cancer than others.   view more (2006-02-21)

Rare syndrome provides clues on obesity, blood pressure
University of Iowa researchers have found a clue about how resistance to the hormone leptin might disrupt the brain signals that tell the body when to stop eating.   view more (2008-03-04)

Does the lack of sleep make you fat?
The recent rise in obesity may be partly due to the reduced amount of time we spend asleep, according to new research from the University of Bristol, UK.   view more (2004-12-06)

Ob1, the first commmon obesity gene was located on chromosome 10
Each family has at least one member whose body mass index (BMI, the ratio of the weight in kg to the surface of the body in m2; normal BMI is below 25) is higher than 40 and at least one other member whose BMI is over 27. 380 genetic markers, covering 23 pairs of chromosomes, were studied in order... view more (1998-11-16)

University of Florida study shows leptin could combat type 2 diabetes
University of Florida researchers have discovered the appetite-controlling hormone leptin could also combat type 2 diabetes, a disease that has become a growing problem in the United States as more Americans pack on extra pounds.   view more (2006-09-21)
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