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Pair of microRNA molecules controls major oncogene in most common leukemia
Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world. view more (2006-12-18)
A Broken Stress Response System Can Contribute to Gleevec Resistance
New clues to why some kinds of leukemia are more aggressive and deadly than others are coming from research examining the types of genetic damage that allow some blood cells to grow out of control, scientists report. view more (2006-04-21)
Silencing a protein could kill T-Cells, reverse leukemia
Blocking the signals from a protein that activates cells in the immune system could help kill cells that cause a rare form of blood cancer, according to physicists and oncologists who combined computer modeling and molecular biology in their discovery. view more (2008-10-23)
Discovery in 'Bubble Boy' disease gene therapy
Scientists at St. Jude Children's Research Hospital have developed a mouse model of a severe disease of the immune system that helps explain why gene therapy used to treat children with this disease at an institution in Europe caused some of them to develop leukemia. view more (2006-08-02)
New Chemo Cocktail Blocks Breast Cancer Like a Fence
Think of a protective fence that blocks the neighbor's dog from charging into your backyard. The body, too, has fences -- physical and biochemical barriers that keep cells in their place. view more (2009-10-07)
How cells change gears: New insights published in Nature Genetics
Bioinformatics researchers from UC San Diego just moved closer to unlocking the mystery of how human cells switch from "proliferation mode" to "specialization mode." This computational biology work from the Jacobs School of Engineering's bioengineering department could lead to new ideas for curbing unwanted cell... view more... (2009-04-21)
New biomarker may predict leukemia aggressiveness
Scientists at the University of California, San Diego and the Moores UCSD Cancer Center have evidence of a potential new biomarker to predict the aggressiveness of an often difficult-to-treat form of leukemia. view more (2009-04-20)
Complete response with oblimersen combination improves survival of CLL patients
Relapsed chronic lymphocytic leukemia (CLL) patients who had a complete response to combination therapy that included the drug oblimersen survived significantly longer than patients treated with chemotherapy alone, a team led by researchers at The University of Texas M. D. Anderson Cancer Center reports at the 49th Annual Meeting of the American... view more... (2007-12-10)
Gene shut-down may offer early warning of chronic leukemia
A new study shows that certain genes are turned off early, before clinical signs of the disease appear, in the development of chronic leukemia. view more (2009-08-06)
Steroids and chicken pox not a good mix
Children who have been treated with steroids and are exposed to chicken pox tend to have a more severe case of the virus. view more (2005-10-19)
OHSU Cancer Institute researchers identify new approach to help control drug resistance in leukemia
Oregon Health & Science University Cancer Institute researchers have found that an experimental drug known as SGX393 is effective against Gleevec-resistant chronic myeloid leukemia (CML). The results of their study will be published the week of March 24th in the Proceedings of the National Academy of Sciences. view more (2008-03-25)
Arsenic-based therapy shown to help eradicate leukemia-initiating cells
In both leukemia and solid tumors, there exists among the multitude of warrior cancer cells a small subgroup that work undercover, patiently lying in wait to launch their attacks. view more (2008-05-13)
Retinol for combating leukemia cells
Vitamin A, also known as retinol, is present in milk, liver, egg yolk, butter and other foodstuffs and as carotene in vegetables that have a yellow-orange colour, such as carrots and pumpkins. view more (2006-01-09)
Comprehensive look at rare leukemia finds relatively few genetic changes launch disease
The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps. view more (2009-07-28)
Gene mutation improves leukemia drug's effect
Gene mutations that make cells cancerous can sometimes also make them more sensitive to chemotherapy. A new study led by cancer researchers at Ohio State University shows that a mutation present in some cases of acute leukemia makes the disease more susceptible to high doses of a particular anticancer drug. view more (2008-06-18)
Mayo Clinic Cancer Center collaborating to find new tools to fight leukemia
Mayo Clinic Cancer Center, working in collaboration with Ohio State University Comprehensive Cancer Center, presented evidence Sunday that a novel regimen of three chemotherapy drugs, pentostatin, cyclophosphamide and rituximab, resulted in significant clinical response in patients with previously untreated chronic lymphocytic leukemia (CLL). view more (2006-12-11)
Scientists develop new, molecular approach to early cancer detection
Scientists have pioneered a new approach to detecting cancer cells, one that could eventually allow doctors to discover many malignancies earlier than currently possible. view more (2006-07-28)
Mutant genes in high-risk childhood leukemias identified
A research team has pinpointed a new class of gene mutations, which identify cases of childhood acute lymphoblastic leukemia (ALL) that have a high risk of relapse and death. view more (2009-05-20)
Study finds heart failure is rare among leukemia patients on imatinib
Congestive heart failure rarely occurs among leukemia patients who take imatinib, researchers at The University of Texas M. D. Anderson Cancer Center found after an exhaustive review of the detailed medical histories of 1,276 patients who enrolled in clinical trials for the drug. view more (2007-09-07)
Three molecular triggers threaten leukemia patients
The road to better treatment for the most common form of adult leukemia will require blocking multiple molecular pathways that fuel the disease. view more (2006-10-04)
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