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Are bone marrow mononuclear cells effective in reducing hepatic lesions?
Liver fibrosis occurs in the setting of chronic injury caused by different etiologies constituting a serious worldwide public health problem. In addition to schistosomiasis, hepatopathies due to alcohol, viral hepatitis, drugs, metabolic and autoimmune diseases, and congenital abnormalities are important causes of liver fibrosis. view more (2008-10-24)
An effective strategy for inhibition of cirrhosis
In China, the incidence of liver cirrhosis is still high, although new therapeutic approaches have recently been proposed, there is no established therapy for liver fibrosis, and Authors investigated the prevention effects of Chinese Medicine Qianggan-Rongxian Soup on liver fibrosis induced by DMN in rat. view more (2008-09-25)
Losing a bit of weight and doing some exercise slows progression of chronic liver disease
Losing weight and exercising regularly slows progression of chronic liver disease in those who are overweight, indicates a study in Gut. Being overweight is bad for the liver. And non-alcoholic fatty liver is increasingly being diagnosed in those who are overweight, diabetic, or who have insulin resistance syndrome, a precursor to diabetes.... view more... (2004-02-11)
The vasculature emerges as a potential therapeutic target in treating ADPKD liver cysts
As part of an effort to develop effective medical therapies that block the progression of liver cyst growth in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), researchers at the University of Colorado Anschutz Medical Center have found that the liver cyst walls develop and maintain a vasculature as they grow out from the body... view more... (2009-09-24)
New toxicity test could cut animal testing
To test whether chemicals are toxic to humans, researchers need to use liver cells that have been freshly harvested from mice or other mammals. A new collection of stable cell lines, described in BMC Biotechnology this week, could reduce the numbers of animals needed in such experiments. The MMH-GH cell lines are derived from the liver cells of... view more... (2004-03-17)
Is bilateral liver resection safe for bilateral intrahepatic stones?
A research article to be published on August 7, 2009 in the World Journal of Gastroenterology addresses this question. In the present study, 101 consecutive patients with bilateral intrahepatic stones who underwent bilateral liver resection in the past 10 years were reviewed retrospectively. view more (2009-08-06)
A novel method of isolating high quality RNA from Kupffer cells
Kupffer cells, resident tissue macrophages that line the liver sinusoids, play a key role in modulating inflammation in a number of experimental models of liver injury. view more (2009-04-17)
Incidence of Fatty Liver Disease rises as obesity in children increases
Indiana University School of Medicine researchers are taking a closer look at a disease whose incidence is rising as obesity in children increases. Non-Alcoholic Steatohepatitis, more popularly known as Fatty Liver Disease, occurs in approximately 15% of obese children. view more (2007-03-16)
Liver regeneration may be simpler than previously thought
The way the liver renews itself may be simpler than what scientists had been assuming. A new study, appearing in the April 13 issue of The Journal of Biological Chemistry, provides new information on the inner workings of cells from regenerating livers that could significantly affect the way physicians make livers regrow in patients with liver... view more... (2007-04-12)
Is molecular adsorbent recirculating system effective for all the liver failure patients?
Since its introduction in 1993, molecular adsorbent recirculating system (MARS) albumin dialysis has been a subject of research, with the hope of treating effectively patients with acute liver failure. view more (2009-07-08)
A breath of fresh air could improve drug toxicity screening
A team led by Massachusetts General Hospital (MGH) researchers has developed an innovative way to culture liver cells for drug toxicity screening. view more (2009-09-03)
Large DNA stretches, not single genes, shut off as cells mature
Experiments at Johns Hopkins have found that the gradual maturing of embryonic cells into cells as varied as brain, liver and immune system cells is apparently due to the shut off of several genes at once rather than in individual smatterings as previous studies have implied. view more (2009-01-20)
Is extra-corporal liver support with prometheus safe in patients with end-stage liver disease?
Patients with end-stage liver disease would benefit from liver supportive liver therapy while waiting for stabilization of hepatic functions or to enable bridging to liver transplantation. view more (2008-05-21)
Severe sleep apnea may be a risk factor for liver damage
Many patients with obstructive sleep apnea (OSA) are obese and therefore at risk of having fatty liver, a condition in which fat accumulates in the liver cells. But the link between OSA and liver injury independent of weight has yet to be examined. view more (2005-05-25)
Transplanted liver cells function in older animals but do not proliferate as much as in younger ones
When things go right, transplanted healthy liver cells transplanted by infusion or injection will find their way to the liver, integrate into the damaged tissue, start proliferating, and take over the liver's work of helping with digestion and removing waste products and worn-out cells from the blood. view more (2009-04-20)
Researchers characterize potential protein targets for malaria vaccine
Researchers from Nijmegen and Leiden have now characterized a large number of parasite proteins that may prove useful in the development of a human malaria vaccine. view more (2008-10-31)
Targeting the protein AEG1 impairs human liver cancer growth in mice
Hepatocellular carcinoma (HCC) is a highly aggressive form of liver cancer and one of the 5 most common cancers worldwide. Devanand Sarkar and colleagues, at Virginia Commonwealth University School of Medicine, Richmond, have now identified a gene that is expressed at high levels in human HCC tumor samples and generates a protein important for HCC... view more... (2009-02-17)
Risk threshold of daily alcohol intake and drinking duration in liver injury?
Alcoholic threshold effect rather than a dose-response effect on mortality from alcohol-related liver injury. Alcohol intake, rather than the type of alcoholic beverage, was more significant to liver injury. view more (2008-05-21)
Study shows liver an excellent target for cancer gene therapy using viral vectors
A featured paper in the February 14 issue of Nature Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells. view more (2007-02-15)
Worrying rise in deaths from alcoholic liver disease
Deaths from alcoholic liver disease have increased in the West Midlands in the past decade, reflecting a nationwide trend, according to researchers in this week's BMJ. The study was set in three boroughs in the West Midlands with a total population of 837,000. Death rates were obtained from the Office for National Statistics. Deaths from primary... view more... (2002-08-07)
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