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GSF scientists examine the role of small sputum macrophages in the widespread disease chronic obstructive bronchitis
COPD (chronic obstructive pulmonary disease) is one of the most common fatal diseases worldwide. In Germany alone, there are about 3-5 million patients affected. COPD includes both chronic obstructive bronchitis and emphysema. Both represent irreversible changes of the central and lower respiratory tract which are accompanied by coughing, mucus... view more... (2005-01-10)
Parasites that live inside cells use loophole to thwart immune system
St. Jude Children's Research Hospital scientists have discovered a mechanism by which intracellular pathogens can shut down one of the body's key chemical weapons against them: nitric oxide. view more (2008-11-04)
Component of red wine quells inflammation in chronic inflammatory lung disease (COPD)
A component of red wine, resveratrol, seems to damp down the inflammatory process in the progressive lung disease COPD, finds a small study in Thorax. So effective was resveratrol in laboratory tests that the authors suggest that the compound could be developed to treat the disease. COPD (chronic obstructive pulmonary disease) is irreversible and... view more... (2003-10-24)
The immune system and Alzheimer's disease
Utrecht researchers, funded by NWO, have determined the role played by brain cells from the immune system that are located close to dying memory cells. The research will help determine the causes of Alzheimer's disease. In patients with Alzheimer's disease, the brain cells die off. The death of these neurones takes place primarily in the vicinity... view more... (2001-11-27)
UCSB researchers discover shape matters to macrophages
Researchers at UC Santa Barbara have made a surprising discovery: phagocytosis depends more on particle shape than size. view more (2006-03-22)
Chemical found in curry may help immune system clear amyloid plaques found in Alzheimer's disease
UCLA/VA researchers found that curcumin - a chemical found in curry and turmeric - may help the immune system clear the brain of amyloid beta, which form the plaques found in Alzheimer's disease. view more (2006-10-04)
Einstein researchers identify potential target for metastatic cancer
The deadliest part of the cancer process, metastasis, appears to rely on help from macrophages, potent immune system cells that usually defend vigorously against disease, researchers at Albert Einstein College of Medicine of Yeshiva University report. view more (2009-08-11)
A molecule impedes the destruction of the 'Brucella' bacteria
Research carried out with the participation of the University of Navarra has shown how a determinate molecule helps an important pathogen, Brucella abortus, escape destruction within the cells charged with eliminating infectious agents (macrophages). view more (2005-06-15)
Team IDs weakness in anthrax bacteria
MIT and New York University researchers have identified a weakness in the defenses of the anthrax bacterium that could be exploited to produce new antibiotics. view more (2008-01-25)
Researchers reveal lung's unique innate immune system
For the first time, scientists have documented an organ-specific innate immune system. In research published in the April 18 edition of the journal Immunity, scientists at the University of California, San Diego (UCSD) School of Medicine outline the unique mechanism by which the lung shapes its defensive strategies against microbial invasion. view more (2006-04-19)
Finding protection from tumor growth in unexpected places
Researchers have discovered that an enzyme commonly involved in regulating blood pressure also provides protection from tumor growth when strongly expressed in immune cells. view more (2007-06-06)
Immune cell age plays role in retinal damage in age-related macular degeneration
Studying a mouse model of age-related macular degeneration, the leading cause of blindness in older Americans, scientists at Washington University School of Medicine in St. Louis have found age is key in determining whether damaging blood vessels will form beneath the retina and contribute to vision loss. view more (2007-11-02)
Two drugs may stabilize plaques in atherosclerosis
Two drugs that a Wake Forest University School of Medicine research team has been investigating for lupus for several years may stabilize atherosclerotic plaque in the walls of arteries and help avert heart attacks and strokes. view more (2006-11-13)
New study overturns orthodoxy on how macrophages kill bacteria
For decades, microbiologists assumed that macrophages, immune cells that can engulf and poison bacteria and other pathogens, killed microbes by damaging their DNA. A new study from the University of Illinois disproves that. view more (2009-04-28)
UCF researchers discover a new protein family implicated in inflammatory diseases
A University of Central Florida research team has discovered a new protein family that may play an important role in preventing inflammatory diseases such as arthritis, some forms of cancer and even heart disease. view more (2008-03-11)
Noninvasive magnetic resonance imaging may help predict who's at risk for a heart attack
The study suggests that magnetic resonance imaging (MRI)—a highly sensitive technique that provides three-dimensional views of tissue at the molecular level—effectively measured macrophages or white blood cells, in the arterial walls of blood vessels. view more (2007-01-29)
Stanford study identifies cellular mechanism that causes lupuslike symptoms in mice
Macrophages, the scavenger cells of the body's immune system, are responsible for disposing of dying cells. Stanford University School of Medicine researchers have identified one pathway in this important process in mice that, if disrupted, causes a lupuslike autoimmune disease. view more (2009-10-19)
Persistent bacterial infection exploits killing machinery of immune cells
A new study reveals an important and newly discovered pathway used by disease-causing bacteria to evade the host immune system and survive and grow within the very cells meant to destroy them. This discovery may lead to new treatments and vaccines for tuberculosis (TB) and certain other chronic bacterial and parasitic infections. view more (2008-11-03)
New evidence supports century-old theory of cancer spread
A Yale School of Medicine study in the December issue of Lancet Oncology challenges mainstream oncology researchers to consider tumor cell hybridization with white blood cells as a major reason that cancer metastasizes or spreads to other parts of the body. view more (2005-12-13)
Scientists shine new light on inflammatory diseases
Investigators at Hospital for Special Surgery have identified a new mechanism involved in the pathogenesis of inflammatory diseases such as rheumatoid arthritis. view more (2008-03-17)
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