Macrophages Current Events | Macrophages News | 4
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UCSD researchers discover inflammation, not obesity, cause of insulin resistance
Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and Type 2 diabetes. view more (2007-11-07)
A genetic cause for iron deficiency
The discovery of a gene for a rare form of inherited iron deficiency may provide clues to iron deficiency in the general population - particularly iron deficiency that doesn't respond to iron supplements - and suggests a new treatment approach. view more (2008-04-14)
Newly Identified Mechanism Helps Explain Why People of African Descent Are More Vulnerable to Tuberculosis
A team of scientists has identified a cellular mechanism that may help explain the puzzle of why people of African descent are more susceptible to tuberculosis infection and why, once infected, they develop more severe states of the disease than whites. view more (2006-02-27)
Pitt study finds molecular link between insulin resistance and inflammation
An exploration of the molecular links between insulin resistance and inflammation may have revealed a novel target for diabetes treatment, say scientists at the John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh of UPMC. view more (2009-08-27)
Iron - the bad guy in haemophilic chronic joint disease?
Mutations in the HFE gene, which is involved in iron regulation, seem to be directly associated with chronic joint disease (or haemophilic arthropathy) among haemophilic patients, claim a team of Portuguese scientists in the April issue of the journal Blood. The results, from a small group of hemophilic patients, if confirmed in a larger... view more... (2005-04-04)
MS patients have higher spinal fluid levels of suspicious immune molecule
A protein that helps keep immune cells quiet is more abundant in the spinal fluid of patients with multiple sclerosis (MS), further boosting suspicion that the protein, TREM-2, may be an important contributor to the disease. view more (2008-09-30)
U of I study shows benefits of hormone found in fat tissue
It's called the obesity paradox. Although obese people are more apt to suffer from inflammatory diseases, such as diabetes, heart disease, and stroke, they are also more likely to survive a major attack caused by one of those conditions. view more (2009-02-27)
Secrets to antibody's success against West Nile Virus surprise scientists
A monoclonal antibody that can effectively treat mice infected with West Nile virus has an intriguing secret: Contrary to scientists' expectations, it does not block the virus's ability to attach to host cells. view more (2005-09-29)
'Underground' tunnels discovered as means for communication between immune system cells
Immune system cells are connected to each other by an extensive network of tiny tunnels that, like a building's hidden pneumatic tube system, are used to shoot signals to distant cells. view more (2005-09-21)
Reactive oxygen in fruit flies acts as a cell signalling mechanism for immune response
For years, health conscious people have been taking antioxidants to reduce the levels of reactive oxygen in their blood and prevent the DNA damage done by free radicals, which are the result of oxidative stress. But could excessive use of antioxidants deplete our immune systems? view more (2009-09-24)
LIAI launches new division to look at novel approaches to heart disease and inflammation
While cholesterol-lowering drugs and new technologies have significantly advanced the nation's battle against heart disease, it continues to rank as the No. 1 killer of U.S. men and women. But if researchers at the La Jolla Institute for Allergy & Immunology (LIAI) have their way, the body's immune system will become an important player in... view more... (2008-09-30)
Researchers discover 'acquired' DNA key to certain bacterial infection
Researchers announced this week the discovery of a mechanism by which Mycobacterium avium - a bacterium which can result in serious lung infections and is prevalent in emphysema and AIDS patients among others - infects tissue cells or "macrophages" and thus compromises the body's immunity. view more (2007-06-19)
New therapeutic target identified for rheumatoid arthritis
Researchers at Hospital for Special Surgery have identified a potential new therapeutic target that could be used to treat inflammatory disorders, such as rheumatoid arthritis. view more (2008-11-05)
Sphingolipids with therapeutic ends
Sphingolipids have been known for more than 120 years but, up to recently, they were thought to be molecules that simply complied with a structural function, acting, as it were, as the building blocks of the biological membranes. view more (2007-03-05)
Seeking to create better drugs, researchers chip away at how tuberculosis survives inside human defense cells
Cornell researchers are using advanced genetic techniques to better understand the relationship between the bacteria that cause tuberculosis and the human immune system defense cells that engulf them. view more (2007-12-26)
How red blood cells nuke their nuclei
Unlike the rest of the cells in your body, your red blood cells lack nuclei. That quirk dates back to the time when mammals began to evolve. Other vertebrates such as fish, reptiles, and birds, have red cells that contain nuclei that are inactive. Losing the nucleus enables the red blood cell to contain more oxygen-carrying hemoglobin, thus... view more... (2008-02-11)
Who is the arch-criminal in the development of hepatopulmonary syndrome?
The hepatopulmonary syndrome (HPS) develops when an arterial oxygenation deficiency occurs due to intra-pulmonary vascular dilatations that are often associated with severe hepatic disease. HPS occurs in 15-20% of patients with liver cirrhosis undergoing evaluation for orthotopic liver transplantation. view more (2007-12-20)
Expansion of monocyte subset could serve as a biomarker for HIV progressions
An increase in the CD163+/CD16+ monocyte subset could be a biomarker for the progression of HIV disease, according to researchers at Temple University. view more (2008-03-28)
Lung cancer cells activate inflammation to induce metastasis
A research team from the University of California, San Diego School of Medicine has identified a protein produced by cancerous lung epithelial cells that enhances metastasis by stimulating the activity of inflammatory cells. view more (2009-01-05)
Infection-fighting protein could be key to autoimmune disease, say U-M scientists
Scientists at the University of Michigan Medical School have discovered that a protein called cryopyrin responds to invading bacteria by triggering the activation of a powerful inflammatory molecule called IL-1beta, which signals the immune system to attack pathogens and induces fever to protect the body against infection. view more (2006-01-12)
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