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Methylation Current Events | Methylation News
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A breakthrough in gastric carcinogenesis
Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. view more (2009-06-12)
Linking DNA and histone methylation
In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes. view more (2007-04-30)
New technique for cancer screening
Current research suggests that a new technique to determine tumor methylation status can be used in archived tissue samples. view more (2009-02-24)
Change in gene may be underlying molecular defect in some colorectal cancers, study suggests
Inactivation of a DNA repair gene may be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for this inactivation may ultimately be useful in risk assessment for colorectal cancer. view more (2005-09-21)
Molecular 'clock' could predict risk for developing breast cancer
A chemical reaction in genes that control breast cancer provides a molecular clock that could one day help researchers more accurately determine a woman's risk for developing breast cancer and provide a new approach for treatment, UT Southwestern Medical Center researchers have found. view more (2008-05-14)
Previously unseen switch regulates breast cancer response to estrogen
A tiny modification called methylation on estrogen receptors prolongs the life of these growth-driving molecules in breast cancer cells, according to research by scientists at Emory University's Winship Cancer Institute. view more (2008-05-09)
Genomic imprinting in disruptive spermatogenesis (p 1700)
Low sperm counts could be associated with genomic imprinting disease and could carry a raised risk of transmitting imprinting defects following assisted reproductive technologies, claim researchers in this week's issue of THE LANCET. Genomic imprinting is a gene regulatory mechanism based on differential methylation, whereby only one of two... view more... (2004-05-19)
DNA test shows promise for identifying patients with colorectal cancer (p 1283)
Testing for DNA changes in stools might provide a new, accurate, and less invasive way to screen patients for colorectal cancer, conclude the authors of a research letter in this week's issue of THE LANCET. Colorectal cancer is one of the most common cancers in the industrialised world, and early detection might help to reduce the risk of death... view more... (2004-04-14)
Human embryonic stem cells display a unique pattern of chemical modification to DNA
Scientists from the Burnham Institute for Medical Research (BIMR) and Illumina Inc., in collaboration with stem cell researchers around the world, have found that the DNA of human embryonic stem cells is chemically modified in a characteristic, predictable pattern. view more (2006-08-07)
Kiss goodbye to biopsies
JUST a drop of blood or urine might be enough to reveal if a patient has cancer, what type it is and whether it`s treatable. "One day, there could be one biochip for analysing all cancers," says Christian Piepenbrock, head of bioinformatics at Epigenomics of Berlin. Its technique distinguishes... view more... (2002-03-06)
Changes to DNA linked to diabetes
Genes that regulate the energy consumption of cells have a different structure and expression in type II diabetics than they do in healthy people, according to a new study from the Swedish medical university Karolinska Institutet published in Cell Metabolism. view more (2009-09-02)
Making memories that last a lifetime
Neurobiologists have discovered a mechanism by which the constantly changing brain retains memories—from that dog bite to that first kiss. They have found that the brain co-opts the same machinery by which cells stably alter their genes to specialize during embryonic development. view more (2007-03-15)
DNA editing tool flips its target
Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation. view more (2008-09-04)
The evolutionary foundation of genomic imprinting in lower vertebrates
A Chinese scientist group working in College of Life Science, Zhejiang University, has shown that, as mammalian Igf2 CpG island, goldfish Igf2 CpG island has a parental differentially methylated region (DMR). view more (2009-05-18)
Gladstone scientists identify key factor that controls HIV latency
Scientists at the Gladstone Institutes of Virology and Immunology (GIVI) have found another clue that may lead to eradication of HIV from infected patients who have been on antiretroviral therapy. view more (2009-06-26)
Novel epigenetic markers of melanoma may herald new treatments for patients
Melanoma is the most serious form of skin cancer, diagnosed in more than 50,000 new patients in the United States annually. While the rate of incidences continues to rise, survival rate has not improved and the race is on to find the genetic and cellular changes driving melanoma and to devise new means of detection and treatment. view more (2009-06-30)
Gene packaging tells story of cancer development
To decipher how cancer develops, Johns Hopkins Kimmel Cancer Center investigators say researchers must take a closer look at the packaging. view more (2008-12-05)
Scientists Develop Technology To Detect Cancer
Researchers at the University of Liverpool have developed a breakthrough technology that identifies molecular markers in early lung cancer. view more (2005-04-20)
Cancer cells suppress large regions of DNA by a reversible process that can be tackled
Cancer researchers at Sydney's Garvan Institute, in collaboration with Spanish scientists, have formulated a new concept for how cancer cells can escape normal growth controls, which may have far-reaching implications for the new generation of cancer therapies. view more (2006-04-24)
Study finds 231 new genes associated with head and neck cancer
A Henry Ford Hospital study has identified 231 new genes associated with head and neck cancer, one of the most deadly cancers responsible for 2.1 percent of all cancer deaths in the United States. view more (2009-10-05)
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