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Methylation Current Events | Methylation News

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Linking DNA and histone methylation
In the May 15th issue of G&D, Dr. Michael Carey (UCLA's Jonsson Comprehensive Cancer Center) and colleagues lend new insight into the mechanism of epigenetic silencing of euchromatic genes.   view more (2007-04-30)

Change in gene may be underlying molecular defect in some colorectal cancers, study suggests
Inactivation of a DNA repair gene may be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for this inactivation may ultimately be useful in risk assessment for colorectal cancer.   view more (2005-09-21)

Molecular 'clock' could predict risk for developing breast cancer
A chemical reaction in genes that control breast cancer provides a molecular clock that could one day help researchers more accurately determine a woman's risk for developing breast cancer and provide a new approach for treatment, UT Southwestern Medical Center researchers have found.   view more (2008-05-14)

Previously unseen switch regulates breast cancer response to estrogen
A tiny modification called methylation on estrogen receptors prolongs the life of these growth-driving molecules in breast cancer cells, according to research by scientists at Emory University's Winship Cancer Institute.   view more (2008-05-09)

Genomic imprinting in disruptive spermatogenesis (p 1700)
Low sperm counts could be associated with genomic imprinting disease and could carry a raised risk of transmitting imprinting defects following assisted reproductive technologies, claim researchers in this week's issue of THE LANCET. Genomic imprinting is a gene regulatory mechanism based on... view more (2004-05-19)

DNA test shows promise for identifying patients with colorectal cancer (p 1283)
Testing for DNA changes in stools might provide a new, accurate, and less invasive way to screen patients for colorectal cancer, conclude the authors of a research letter in this week's issue of THE LANCET. Colorectal cancer is one of the most common cancers in the industrialised world, and early... view more (2004-04-14)

Human embryonic stem cells display a unique pattern of chemical modification to DNA
Scientists from the Burnham Institute for Medical Research (BIMR) and Illumina Inc., in collaboration with stem cell researchers around the world, have found that the DNA of human embryonic stem cells is chemically modified in a characteristic, predictable pattern.   view more (2006-08-07)

Kiss goodbye to biopsies
JUST a drop of blood or urine might be enough to reveal if a patient has cancer, what type it is and whether it`s treatable.         "One day, there could be one biochip for analysing all cancers," says Christian Piepenbrock, head of bioinformatics at... view more (2002-03-06)

Making memories that last a lifetime
Neurobiologists have discovered a mechanism by which the constantly changing brain retains memories—from that dog bite to that first kiss. They have found that the brain co-opts the same machinery by which cells stably alter their genes to specialize during embryonic development.   view more (2007-03-15)

DNA editing tool flips its target
Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation.   view more (2008-09-04)

Scientists Develop Technology To Detect Cancer
Researchers at the University of Liverpool have developed a breakthrough technology that identifies molecular markers in early lung cancer.   view more (2005-04-20)

Cancer cells suppress large regions of DNA by a reversible process that can be tackled
Cancer researchers at Sydney's Garvan Institute, in collaboration with Spanish scientists, have formulated a new concept for how cancer cells can escape normal growth controls, which may have far-reaching implications for the new generation of cancer therapies.   view more (2006-04-24)

Our genome changes over lifetime, Johns Hopkins experts say
Researchers at Johns Hopkins have found that epigenetic marks on DNA-chemical marks other than the DNA sequence-do indeed change over a person's lifetime, and that the degree of change is similar among family members.   view more (2008-06-25)

Scientists find clue to mechanisms of gene signaling and regulation
Scientists have discovered a pattern in the DNA sequence of the mouse genome that may play a fundamental part in the way DNA molecules regulate gene expression.   view more (2007-08-23)

DNA methylation shown to promote development of colon tumors
Damaged or defective genes have long been known to be the cause of some cancers. Over the past decade, however, scientists have discovered that even healthy genes can be switched on or off and can cause cancer without any changes in the underlying DNA sequence-although how this happens has remained... view more (2007-12-03)

Mouth may tell the tale of lung damage caused by smoking
Cells lining the mouth reflect the molecular damage that smoking does to the lining of the lungs, researchers at The University of Texas M. D. Anderson Cancer Center report today at the annual meeting of the American Association for Cancer Research.   view more (2008-04-14)

In a technical tour de force, Salk scientists take a global view of the epigenome
A collaboration between researchers at the Salk Institute for Biological Studies and the University of California at Los Angeles captured the genome-wide DNA methylation pattern of the plant Arabidopsis thaliana-the "laboratory rat" of the plant world-in one big sweep.   view more (2006-09-01)

Waterborne carbon increases threat of environmental mercury
Mercury is a potent neurotoxin and a worrisome environmental contaminant, but the severity of its threat appears to depend on what else is in the water.   view more (2007-12-11)

USC researchers explore genetic causes for male infertility
Researchers at the University of Southern California (USC) suggest epigenetics, or the way DNA is processed and expressed, may be the underlying cause for male infertility. The study will be published in the Dec. 12 issue of Public Library of Science One.   view more (2007-12-12)

First evidence that genetic imprinting occurs at earliest stage in test tube-matured eggs
Madrid, Spain: New research indicates that attempts to mature ovarian follicles in the laboratory may hit a stumbling block unless better 'growing' conditions can be identified. A French team[1] of fertility experts has revealed for the first time that maternal genetic imprinting errors can occur... view more (2003-06-27)

Subtle changes in normal genes implicated in breast cancer
Using a super-efficient method they invented to search for a type of cancer-related change in all genes of a cell, Dana-Farber Cancer Institute researchers have discovered new evidence about how the "microenvironment" of breast cancers helps drive the cancers' growth and migration.   view more (2005-07-14)

Protein protects anti-cancer gene from chemical shutdown
A protein that is largely absent in one type of skin cancer protects an important gene in a cell's defense against harmful mutations from being silenced.   view more (2007-07-20)

EARLY PROMISE OF NEW TECHNIQUE TO IDENTIFY BREAST CANCER
The analysis of breast-duct fluid, collected through ductal lavage (washing), could be a novel method for detecting breast-cancer cells when used in conjunction with mammography screening, conclude authors of a fast-track research letter in this week's issue of THE LANCET. If detected early, breast... view more (2001-04-25)

Early estrogen exposure leads to later prostate cancer risk
A study in the June 1 issue of Cancer Research presents the first evidence that exposure to low doses of environmental estrogens during development of the prostate gland in the male fetus may result in a predisposition to prostate cancer later in life.   view more (2006-06-01)

Novel enzyme offers new look at male hormone regulation
For the second time in less than a year, University of North Carolina at Chapel Hill scientists have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent.   view more (2006-05-08)
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