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Methylation Current Events | Methylation News | 2
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Novel enzyme offers new look at male hormone regulation For the second time in less than a year, University of North Carolina at Chapel Hill scientists have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent. view more (2006-05-08)
Centromeres cross over, a lot Recombination at centromeres is higher than anywhere else on the chromosome, even though methyltransferases do their best to prevent it, say Jaco et al., as published in the June 16 issue of the Journal of Cell Biology. view more (2008-06-13)
'Smothered' genes combine with mutations to yield poor outcome in cancer patients Johns Hopkins Kimmel Cancer Center researchers have identified a set of genes in breast and colon cancers with a deadly combination of traditional mutations and "smothered" gene activity that may result in poor outcomes for patients. view more (2008-07-16)
First evidence that prenatal exposure to famine may lead to persistent epigenetic changes A study initiated by researchers at Columbia University Mailman School of Public Health and the Leiden University Medical Center in the Netherlands suggests that prenatal exposure to famine can lead to epigenetic changes that may affect a person's health into midlife. view more (2008-10-31)
Novel regulatory mechanism identified for key tumor suppressor p53 Collaborating scientists from The Wistar Institute in Philadelphia and The Vienna Biocenter in Austria have identified a novel mechanism involved in normal repression of the p53 protein, perhaps the single most important molecule for the control of cancer in humans. view more (2006-11-16)
Profiling of cancer genes may lead to better and earlier detection A research team at UT Southwestern Medical Center has for the first time identified several genes whose expression is lost in four of the most common solid human cancers - lung, breast, prostate and colon cancer. view more (2006-12-27)
How plants remember winter, in order to flower in spring Scientists at the John Innes Centre (JIC) Norwich (1), have discovered the molecular change that allows plants to remember winter. Many plants need a cold period (3-8 weeks at 4o - 8oC) early in their growth to stimulate them to flower, this is called vernalisation, and without a suitable cold... view more (2004-01-06)
Researchers find protein that silences genes A team of researchers, including biologists at Washington University in St. Louis, has discovered the key role one protein plays in a major turn-off - in this case, the turning off of thousands of nearly identical genes in a hybrid plant. view more (2006-05-08)
Silence please Researchers at Cambridge University have been studying the process of gene silencing in transgenic plants, and have cloned a genetic modifier that could reduce transgene instability. Dr Ian Furner will be presenting the results of the study at the Society for Experimental Biology conference on... view more (2002-04-04)
Prenatal Genistein In Soy Reduces Obesity In Offspring A single nutrient found in soy products elicits changes in gene behavior that permanently reduce an embryo's risk of becoming obese later in life, according to an animal study at Duke University Medical Center. view more (2006-03-29)
New molecules discovered that block cancer cells from modifying cell DNA Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. view more (2007-10-12)
Finding may eventually help tailor treatment for depression When a treatment works for one person's depression, it does not always work for another person's. Findings from the University of Iowa may one day help doctors have a better idea of who will benefit from specific antidepressants, increasing the likelihood of successful treatment. view more (2007-11-08)
Stem cells could reveal secrets of illness in later life Mums to be have known for some time that what they eat when pregnant affects their unborn child but now scientists believe that the diet of our mothers during pregnancy may even affect our predisposition to illnesses such as heart disease, diabetes and high blood pressure in late life. view more (2004-12-24)
Researchers may have unlocked the mechanisms that silence the estrogen receptor gene alpha during breast cancer The mechanisms that silence the estrogen receptor gene alpha (ER-α) in certain breast cancer cell lines may be closer to being unlocked. view more (2007-08-20)
Breast cancer amongst young women Breast cancer is the most common and the second-most fatal malignant tumour amongst women who live in industrialised countries. Moreover, when present in young women, it would appear that a genetic predisposition is involved. This predisposition can be due to a number of causes and, amongst the... view more (2003-11-14)
Researchers find better prostate cancer indicators Researchers at Mayo Clinic have narrowed the search for effective prostate cancer biomarkers (genetic variations that point to a specific disease or condition), identifying changes in the expression of genes of the whole genome closely correlated to prostate cancer development and progression. view more (2006-03-28)
Study links breast cancer risk to epigenetic changes related to race, smoking and birth size Women can encounter environmental factors that increase their risk of breast cancer at various periods of their physical development, beginning before birth and extending until menopause. view more (2007-04-16)
Enzyme complex thought to promote cancer development can also help prevent it In a case of basic science detective work, researchers at The University of Texas M. D. Anderson Cancer Center have solved the puzzle of the "inconsistent biomarker" and, in the process, may have discovered an agent that can suppress cancer development. view more (2005-10-14)
Trial shows which brain cancer patients benefit from temozolomide Genetic predictive test clears way for targeted drug treatment view more (2004-09-26)
USC study in Nature Genetics supports a stem cell origin of cancer Researchers at the University of Southern California (USC) recently made significant strides toward settling a decades-old debate centering on the role played by stem cells in cancer development. view more (2007-01-10)
Stem cells give clues to understanding cancer and make breakthrough in childhood leukaemia Scientists in Switzerland are uncovering new clues about how cancer cells grow - and how they can be killed - by studying stem cells, 'blank' cells that have the potential to develop into fully mature or 'differentiated' cells and other scientists in UK have made a breakthrough in understanding the... view more (2008-02-14)
Embryonic stem cells accrue genetic changes An international team of researchers has discovered that human embryonic stem cell lines accumulate changes in their genetic material over time. view more (2005-09-06)
NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents Researchers at the National Sun Yat-Sen University and Kaohsiung Medical University, Kaohsiung, Taiwan have revealed a new mechanism by which nonsteroidal anti-inflammatory drugs (NSAIDs) attenuate tumor invasion and metastasis. view more (2008-03-27)
A twist of fate -- Reprogrammed fibroblasts resemble embryonic stem cells Stem cell biology takes another exciting leap forward as scientists report that normal tissue cells can be reprogrammed to exhibit many of the properties that are characteristic of embryonic stem cells, including the ability to give rise to multiple cell types and contribute to the germline. view more (2007-06-07)
Regulating the Nuclear Architecture of the Cell An organelle called the nucleolus resides deep within the cell nucleus and performs one of the cell's most critical functions: it manufactures ribosomes, the molecular machines that convert the genetic information carried by messenger RNA into proteins that do the work of life. view more (2006-12-11)
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