Methylation Current Events | Methylation News | 2
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Newly found enzymes may play early role in cancer Researchers have discovered two enzymes that, when combined, could be involved in the earliest stages of cancer. Manipulating these enzymes genetically might lead to targeted therapies aimed at slowing or preventing the onset of tumors. view more (2008-12-29)
Our genome changes over lifetime, Johns Hopkins experts say Researchers at Johns Hopkins have found that epigenetic marks on DNA-chemical marks other than the DNA sequence-do indeed change over a person's lifetime, and that the degree of change is similar among family members. view more (2008-06-25)
Scientists find clue to mechanisms of gene signaling and regulation Scientists have discovered a pattern in the DNA sequence of the mouse genome that may play a fundamental part in the way DNA molecules regulate gene expression. view more (2007-08-23)
DNA methylation shown to promote development of colon tumors Damaged or defective genes have long been known to be the cause of some cancers. Over the past decade, however, scientists have discovered that even healthy genes can be switched on or off and can cause cancer without any changes in the underlying DNA sequence-although how this happens has remained poorly understood. view more (2007-12-03)
Mouth may tell the tale of lung damage caused by smoking Cells lining the mouth reflect the molecular damage that smoking does to the lining of the lungs, researchers at The University of Texas M. D. Anderson Cancer Center report today at the annual meeting of the American Association for Cancer Research. view more (2008-04-14)
In a technical tour de force, Salk scientists take a global view of the epigenome A collaboration between researchers at the Salk Institute for Biological Studies and the University of California at Los Angeles captured the genome-wide DNA methylation pattern of the plant Arabidopsis thaliana-the "laboratory rat" of the plant world-in one big sweep. view more (2006-09-01)
MDC scientists show how hematopoietic stem cell development is regulated During cell division, whether hematopoietic stem cells (HSCs) will develop into new stem cells (self-renewal) or differentiate into other blood cells depends on a chemical process called DNA methylation. view more (2009-10-07)
Silenced genes as a warning sign of blood cancer In many types of cancer, parts of the genetic material of tumor cells are switched off by chemical labels called methyl groups. This kind of methyl labeling ranges among the epigenetic changes that do not change the sequence of DNA building blocks. view more (2009-08-05)
Stowers Institute's Workman Lab discovers novel histone demethylase protein complex The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell. view more (2008-12-08)
Environmental exposures may damage DNA in as few as 3 days Exposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases. view more (2009-05-18)
Waterborne carbon increases threat of environmental mercury Mercury is a potent neurotoxin and a worrisome environmental contaminant, but the severity of its threat appears to depend on what else is in the water. view more (2007-12-11)
USC researchers explore genetic causes for male infertility Researchers at the University of Southern California (USC) suggest epigenetics, or the way DNA is processed and expressed, may be the underlying cause for male infertility. The study will be published in the Dec. 12 issue of Public Library of Science One. view more (2007-12-12)
First evidence that genetic imprinting occurs at earliest stage in test tube-matured eggs Madrid, Spain: New research indicates that attempts to mature ovarian follicles in the laboratory may hit a stumbling block unless better 'growing' conditions can be identified. A French team[1] of fertility experts has revealed for the first time that maternal genetic imprinting errors can occur at the very earliest stages of egg follicle... view more... (2003-06-27)
Subtle changes in normal genes implicated in breast cancer Using a super-efficient method they invented to search for a type of cancer-related change in all genes of a cell, Dana-Farber Cancer Institute researchers have discovered new evidence about how the "microenvironment" of breast cancers helps drive the cancers' growth and migration. view more (2005-07-14)
Perinatal environment influences aggression in children It's a well-documented fact that children from zero to two can be spontaneously aggressive and that boys can be among the worse culprits. Even after being socialized, seven percent of boys will continue to be hyper-aggressive until the age of nine. view more (2009-03-11)
Genes signal late-stage laryngeal cancer, poorer outcome Researchers at Henry Ford Hospital have identified tumor-suppressing genes that may provide a more accurate diagnosis of disease stage and survival for laryngeal cancer patients than current standards. view more (2009-10-08)
In lung cancer, silencing one crucial gene disrupts normal functioning of genome While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. view more (2009-01-05)
Protein protects anti-cancer gene from chemical shutdown A protein that is largely absent in one type of skin cancer protects an important gene in a cell's defense against harmful mutations from being silenced. view more (2007-07-20)
EARLY PROMISE OF NEW TECHNIQUE TO IDENTIFY BREAST CANCER The analysis of breast-duct fluid, collected through ductal lavage (washing), could be a novel method for detecting breast-cancer cells when used in conjunction with mammography screening, conclude authors of a fast-track research letter in this week's issue of THE LANCET. If detected early, breast cancer is curable. Saraswati Sukumar and... view more... (2001-04-25)
Early estrogen exposure leads to later prostate cancer risk A study in the June 1 issue of Cancer Research presents the first evidence that exposure to low doses of environmental estrogens during development of the prostate gland in the male fetus may result in a predisposition to prostate cancer later in life. view more (2006-06-01)
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