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Child abuse may 'mark' genes in the brains of suicide victims
A team of McGill University scientists has discovered important differences between the brains of suicide victims and so-called normal brains. Although the genetic sequence was identical in the suicide and non-suicide brains, there were differences in their epigenetic marking - a chemical coating... view more (2008-05-07)

'Swish-and-spit' test accurate for cancer
A morning gargle could someday be more than a breath freshener - it could spot head and neck cancer, say scientists at the Johns Hopkins Kimmel Cancer Center. Their new study of a mouth rinse that captures genetic signatures common to the disease holds promise for screening those at high risk,... view more (2008-01-02)

Cells in mucus from lungs of high-risk patients can predict tumor development
n a group of high-risk patients, a test that examined DNA from cells expelled in sputum for evidence of "silenced" genes correctly identified the majority of patients who were later diagnosed with lung cancer.   view more (2006-03-15)

Epigenetic research uncovers new targets for modification enzymes
Enzymes regulating genetic expression can be just as important as the genome itself, increasing evidence shows. The expanding field of epigenetics focuses on the multiple influences on DNA and surrounding molecules that determine whether genes are turned on or off during development and disease... view more (2008-04-28)

Why embryos need a good diet
A thick-coated vole and a man with cardiovascular disease have something in common: both are doing what their mothers told them. They are part of the developmental programming phenomenon that is broader than many acknowledge, according to a review paper published in The Journal of Physiology.   view more (2005-05-12)

St. Jude study yields secrets of chromosome movement
Investigators at St. Jude Children's Research Hospital have used the lowly yeast to gain insights into how a dividing human cell ensures that an identical set of chromosomes gets passed on to each new daughter cell.   view more (2007-06-18)

Liver cancer marker could yield blood test for early detection
In the face of an emerging liver cancer crisis in Asia, researchers at the Chinese University of Hong Kong have developed a test that could help millions.   view more (2007-09-18)

Genome communication
In the late 19th century Gregor Mendel used peas to show that one copy of a gene (allele) is inherited from the mother and one from the father.   view more (2008-06-30)

Epigenetics to shape stem cell future
Everyone hopes that one day stem cell-based regenerative medicine will help repair diseased tissue.   view more (2007-02-20)

Depression model leaves mice with molecular scar
In addition to triggering a depression-like social withdrawal syndrome, repeated defeat by dominant animals leaves a mouse with an enduring "molecular scar" in its brain that could help to explain why depression is so difficult to cure.   view more (2006-03-01)

Dental chair a possible source of neurotoxic mercury waste
Mercury is a large component of dental fillings, but it is not believed to pose immediate health risks in that form. When exposed to sulfate-reducing bacteria, however, mercury undergoes a chemical change and becomes methylated, making it a potent, ingestible neurotoxin.   view more (2008-03-27)

Researchers uncover new mechanism of tumor suppressor
Researchers from the University of Colorado-Denver and Health Sciences Center and Stanford University have discovered a molecular mechanism that explains how cells respond to DNA damage and other acute stresses, and if disrupted can cause cancer.   view more (2006-05-22)

Genes offer researchers a 'crystal ball' to help them prevent, diagnose and treat cancer
The science of cancer prevention has advanced to the point where researchers now say they can detect "cancer genes" in the breath of smokers, and can test the presence of two proteins in men they say will predict development of prostate cancer a decade in advance.   view more (2006-11-13)

Cancer scientists call for a large-scale human epigenome project
A vast code, invisible to the DNA sequencing effort that constituted the Human Genome Project, is rapidly being shown to play a direct role in human health. This "epigenome"-from the Greek epi, meaning "in addition to"-consists of chemical "amendments" that dangle like... view more (2005-12-15)

If you think cancer genes are simple, you don't know JAK
Cancer-causing genes can work in more powerful and sneaky ways than have been realized. Scientists have shown that a gene named JAK that is closely related to a common cancer-causing gene in people tips the scales toward cancer in an unexpected manner.   view more (2007-09-18)

Computation to unravel how genes are regulated and shed light on how cells become different
A closer alliance between computational and experimental researchers is needed to make progress towards one of biology's most challenging goals, understanding how epigenetic marks contribute to regulation of gene expression.   view more (2008-04-11)

Effect on Breast Tumors of DNA Alternations in 3 Genes Described
Cancer epidemiologists at the University at Buffalo have identified specific genes that are most likely to become cancer promoters when exposed to a process called DNA promoter hypermethylation.   view more (2007-05-17)

Neural stem cells derived from human embryonic stem cells carry abnormal gene expression
Neural stem cells grown from one of the federally approved human embryonic stem cell lines proved to be inferior to neural stem cells derived from fetal tissue donated for research, a UCLA study has found.   view more (2006-08-07)

A Molecular Basis for Cocaine Abuse: PLoS Biology Press Release
This Is Your Fly's Brain on Drugs Cocaine addiction wreaks profound changes on the brain, hijacking reward circuits and depressing inhibitory loops to the point that drug seeking and taking become central drivers of behavior. While mammalian models are useful for mapping out the neural complexity... view more (2004-11-16)

Liposuctioned fat stem cells to repair bodies
Expanding waistlines, unsightly bulges: people will gladly remove excess body fat to improve their looks. But unwanted fat also contains stem cells with the potential to repair defects and heal injuries in the body.   view more (2007-02-23)

Zeroing in on progeria: How mutant lamins cause premature aging
Children diagnosed with Hutchinson-Gilford Progeria Syndrome (HGPS) race through life against an unfairly fast clock. Cases are extremely rare-one in 8 million births-but time plays cruel tricks on HGPS newborns.   view more (2005-12-14)

Researchers reveal structure of protein that repairs damage to cancer cells
A team of University of Chicago scientists has shown how two proteins locate and repair damaged genetic material inside cells.   view more (2008-04-24)
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