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Making sense of antisense microRNAs
Three independent papers in the January 1st issue of G&D report on the discovery of a bidirectionally transcribed microRNA (miRNA) locus in Drosophila. view more (2008-01-02)
MicroRNA processing and cancer
In an upcoming G&D paper, Dr. Scott Hammond (UNC-Chapel Hill) and colleagues describe a key regulatory step during microRNA biogenesis, which may underlie alterations of microRNA expression in cancer. view more (2006-08-01)
Genetic Engineering & Biotechnology News reports on advances in miRNA
miRNA research is now one of the most interesting areas in the life science world, reports Genetic Engineering and Biotechnology News (GEN). view more (2008-03-03)
Ago2 and hematopoiesis
Argonaute 2 (Ago2) is unique among its family: It is the only one of the four mammalian Argonaute proteins that exhibits endonuclease "slicer" activity (facilitation of miRNA-guided cleavage of target mRNA). view more (2007-07-12)
Biologists develop genome-wide map of miRNA-mRNA interactions
Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans). view more (2006-03-09)
microRNA-mediated metabolism
In the February 15th issue of G&D, Drs. Aurelio Teleman and Stephen Cohen (EMBL) assign one of the first biological functions to an animal microRNA: the microRNA miR-278 regulates energy homeostasis in Drosophila. view more (2006-02-15)
Unicellular microRNA discovery
In the May 15th issue of Genes & Development, an international collaboration of researchers, led by Dr. Yijun Qi (National Institute of Biological Sciences, China), report on their discovery of microRNAs in the unicellular green alga, Chlamydomonas reinhardtii. This is the first finding of... view more (2007-04-30)
Yale scientists show that a microRNA can reduce lung cancer growth
A small RNA molecule, known as let-7 microRNA (miRNA), substantially reduced cancer growth in multiple mouse models of lung cancer, according to work by researchers at Yale University and Asuragen, Inc., published in the journal Cell Cycle. view more (2008-03-24)
Jefferson researchers uncover genetic signature that predicts colon cancer
Researchers at Jefferson Medical College in Philadelphia have uncovered a genetic "signature" that accurately identifies colon cancer-a key, they hope, to better understand how the cancer develops. view more (2006-04-05)
MiRNA Fingerprint Identified in Platelet Formation
Scientists have identified a handful of microRNAs (miRNAs) that appear to play a significant role in the development of platelets - blood cells critical to the body's ability to form clots following an injury. view more (2006-03-17)
New study expands understanding of the role of RNA editing in gene control
For many years, scientists thought gene activity was relatively straightforward: Genes were transcribed into messenger RNA, which was processed and translated into the proteins of the body. view more (2005-12-27)
MicroRNAs may be key to HIV's ability to hide, evade drugs, Jefferson scientists find
Tiny pieces of genetic material called microRNA (miRNA), better known for its roles in cancer, could be a key to unlocking the secrets of how HIV, the AIDS virus, evades detection, hiding in the immune system. view more (2007-10-01)
Pair of microRNA molecules controls major oncogene in most common leukemia
Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world. view more (2006-12-18)
Tiny genes may increase cancer susceptibility, Jefferson scientists find
New evidence indicates that small pieces of noncoding genetic material known as microRNAs (miRNAs) might influence cancer susceptibility. view more (2007-05-24)
Jefferson, Ohio State team find gene signature profile for metastasis
A common signature of tiny, specific pieces of non-coding genetic material known as microRNAs (miRNAs) may be directly involved in the spread of cancer to other parts of the body. view more (2008-06-02)
Twin molecular scissors link creation of microRNAs with gene-silencing
One of the body's primary strategies for regulating its genome is a kind of targeted gene silencing orchestrated by small molecules called microRNAs, or miRNAs. view more (2005-11-04)
Silencing small but mighty cancer inhibitors
Researchers from Johns Hopkins and the University of Pennsylvania have uncovered another reason why one of the most commonly activated proteins in cancer is in fact so dangerous. view more (2007-12-11)
Gene variations alter risk of esophageal cancer
Variations in a common gene pathway may affect esophageal cancer risk, a dangerous and rapidly increasing type of cancer, according to research by scientists at The University of Texas M. D. Anderson Cancer Center. view more (2008-11-06)
Role of microRNA Identified in Thyroid Cancer
The presence of only five tiny strands of RNA is enough to clearly distinguish cancerous thyroid tissue from otherwise normal tissue, scientists say. view more (2005-12-23)
A new kind of mutation could explain numerous phenotypic variations in various species
The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form. view more (2006-06-06)
Less can be more, for plant breeders too
Imagine you are a rice breeder and one day within a large field you discover a plant that has just the characteristics you have been looking for. You happily take your special plant to the laboratory where you find out that the spontaneous, beneficial event was due to inactivation of a single gene. view more (2008-03-20)
Mechanism for the in-vivo transport of siRNA
It all started with flowers: in the nineties of the last century Norwegian researchers discovered that additional copies of a particular gene in petunias inhibited its activity instead of reinforcing it as had been assumed. view more (2007-09-18)
Gladstone researchers hone in on differentiation of heart stem cells
A team of scientists from the Gladstone Institute of Cardiovascular Disease (GICD) has identified a key factor in heart development that could help advance gene therapy for treating cardiac disorders. view more (2005-12-16)
Gladstone scientists identify critical gene factor in heart development
Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) announced they have identified a critical genetic factor in the control of many aspects of heart form and function. view more (2007-03-30)
Bits of 'junk' RNA aid master tumor-suppressor gene
Little-known bits of RNA help master tumor-suppressor gene do its job, U-M cancer researchers find. Three micro RNA genes appear to be key partners of protective gene p53; their loss is linked to common type of lung cancer. view more (2007-08-24)
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