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microRNA-mediated metabolism
In the February 15th issue of G&D, Drs. Aurelio Teleman and Stephen Cohen (EMBL) assign one of the first biological functions to an animal microRNA: the microRNA miR-278 regulates energy homeostasis in Drosophila. view more (2006-02-15)
Xie Lab demonstrates the role of microRNA pathway
Ting Xie, Ph.D., Associate Investigator, and Zhigang Jin, Ph.D., Postdoctoral Research Associate in the Xie Lab, have published results showing that the microRNA pathway is essential for controlling self-renewal of germline stem cells and somatic stem cells in the Drosophila ovary. view more (2007-02-16)
MicroRNA processing and cancer
In an upcoming G&D paper, Dr. Scott Hammond (UNC-Chapel Hill) and colleagues describe a key regulatory step during microRNA biogenesis, which may underlie alterations of microRNA expression in cancer. view more (2006-08-01)
Small molecules may explain psoriasis
A research team at the Swedish medical university Karolinska Institutet has shown for the time that microRNA, small RNA molecules, may play an important role in the development of inflammatory skin diseases such as psoriasis and atopic eczema. view more (2007-07-12)
Single microRNA fine-tunes innate immune response
A single microRNA, microRNA-223, in mice controls the production and activation of granulocytes, white blood cells essential for host defense against invading pathogens. view more (2008-02-20)
Short RNA strand helps exposed skin cells protect body from bacteria, dehydration and even cancer
Every minute, 30,000 of our outermost skin cells die so that we can live. When they do, new cells migrate from the inner layer of the skin to the surface of it, where they form a tough protective barrier. view more (2008-03-03)
Regulatory molecule for tumor formation or suppression identified by Singapore, US researchers
One of the small regulatory molecules, named microRNA-125b, is a novel regulator of p53, an important protein that safeguards cells against cancers, Singapore and U.S. scientists report in the March 17, 2009 issue of the journal Genes & Development. view more (2009-03-18)
Role for microRNAs in limb regeneration
In the March 15th issue of G&D, Dr. Kenneth Poss (Duke University Medical Center) and colleagues reveal that microRNA depletion is a necessary step in tissue regeneration - a discovery with interesting implications for their use in regenerative medicine. view more (2008-03-17)
MicroRNA works with Ago2 protein to regulate blood cell development
MicroRNAs became the stars of the RNA universe when, in 2001, scientists found that these short RNAs can control whether or not genes are expressed. view more (2007-07-27)
Dartmouth researchers find the root of the evolutionary emergence of vertebrates
Dartmouth College researchers and colleagues from the University of Bristol in the U.K. have traced the beginnings of complex life, i.e. vertebrates, to microRNA. The researchers argue that the evolution of microRNAs, which regulate gene expression, are behind the origin of early vertebrates. view more (2008-02-12)
Master switches found for adult blood stem cells
Johns Hopkins Kimmel Cancer Center scientists have found a set of "master switches" that keep adult blood-forming stem cells in their primitive state. view more (2007-02-12)
MicroRNAs Can Be Tumor Suppressors
University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors in laboratory studies. view more (2007-04-26)
Mean new microRNA data analysis method gives sharper results
Our understanding of the importance of microRNAs in regulating gene expression is expanding, and with it our requirement for robust methods to measure their expression levels. view more (2009-06-16)
miR-196a promotes the metastases of tumors
MicroRNAs are small RNA molecules of 20-25 nucleotides length, regulating gene expression by inhibition of transcription or translation of proteins. view more (2009-05-13)
Gladstone scientists identify critical gene factor in heart development
Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) announced they have identified a critical genetic factor in the control of many aspects of heart form and function. view more (2007-03-30)
Renegade RNA — Clues to cancer and normal growth
Researchers at Johns Hopkins have discovered that a tiny piece of genetic code apparently goes where no bit of it has gone before, and it gets there under its own internal code. view more (2007-01-05)
MicroRNA tweaks protein that controls early heart development
Researchers at UT Southwestern Medical Center have discovered how a small molecule of RNA called microRNA - a chemical cousin of DNA - helps fine tune the production of a key protein involved in the early development of heart muscle. view more (2005-06-13)
RNA snippet suppresses spread of aggressive breast cancer
A low cellular level of a tiny fragment of RNA appears to increase the spread of breast cancer in mouse models of the disease, according to researchers at Whitehead Institute for Biomedical Research. view more (2009-06-16)
MicroRNA helps prevent tumors
A microRNA directly regulates a gene implicated in human cancers, researchers from Whitehead Institute and Massachusetts Institute of Technology report in the February 22nd online issue of Science. view more (2007-02-23)
Hebrew University study opening new route for combating viruses
A unique technique for analyzing the function of microRNAs developed by a Hebrew University of Jerusalem doctoral student has led to the discovery of a new mechanism by which viruses evade the human immune system. view more (2008-06-25)
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