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MIT reports new twist in microRNA biology
MIT scientists have found a new way that DNA can carry out its work that is about as surprising as discovering that a mold used to cast a metal tool can also serve as a tool itself, with two complementary shapes each showing distinct functional roles.   view more (2008-01-14)

MicroRNA gene that regulates lifespan found by Yale scientists
Genes that control the timing of organ formation during development also control timing of aging and death, and provide evidence of a biological timing mechanism for aging, Yale researchers report in the journal Science.   view more (2005-12-23)

Molecules can block breast cancer's ability to spread
Researchers have identified a specific group of microRNA molecules that are responsible for controlling genes that cause breast cancer metastasis.   view more (2008-01-10)

A new kind of mutation could explain numerous phenotypic variations in various species
The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form.   view more (2006-06-06)

Killing the messenger RNA — But which one?
Tiny molecules called microRNAs, only 19 to 21 nucleotides in length, are able to effectively silence sometimes large sets of genes. They do this by specifically binding to and neutralizing another form of RNA called messenger RNA, responsible for conveying the information from genes to the... view more (2007-02-23)

Oregon researchers discover a mechanism leading to cleft palate
By creating a genetic mutation in zebrafish, University of Oregon scientists say they've discovered a previously unknown mechanism for cleft palate, a common birth defect in humans that has challenged medical professionals for centuries.   view more (2008-02-12)

MicroRNAs play a big part in gene regulation-and evolution
egulating when and where certain proteins are made is crucial to the normal functioning of living things. To make proteins, information from DNA is transcribed into RNA molecules and then translated into the amino acids building blocks of proteins.   view more (2005-06-24)

Molecules might identify high-risk acute-leukemia patients
New research suggests that certain small molecules used by cells to control the proteins they make might also help doctors identify adult acute-leukemia patients who are likely to respond poorly to therapy.   view more (2008-01-16)

Gladstone scientists identify single microRNA that controls blood vessel development
Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs.   view more (2008-08-12)

Tiny molecule helps control blood-vessel development, researchers find
The development and repair of heart tissue and blood vessels is intimately tied to a tiny piece of ribonucleic acid (RNA) that is found nowhere else in the body, researchers at UT Southwestern Medical Center have found.   view more (2008-08-13)

Short RNAs show a long history
MicroRNAs, the tiny molecules that fine-tune gene expression, were first discovered in 1993. But it turns out they've been around for a billion years.   view more (2008-10-02)

Protein protects embryonic stem cells' versatility and self-renewal
A protein known as REST blocks the expression of a microRNA that prevents embryonic stem cells from reproducing themselves and causes them to differentiate into specific cell types, scientists at The University of Texas M. D. Anderson Cancer Center report in the journal Nature.   view more (2008-03-24)

A small leak will sink a great ship
Flowers of higher plants are built in a similar pattern: their outermost whorl is composed of sepals, which protect the young bud, thereafter comes a whorl of often colorful petals attracting insect pollinators, followed by a whorl of stamens with pollen sacks and the innermost whorl holds carpels,... view more (2007-06-27)

New genetic techniques to combat lung cancer
New results on genetic techniques that are helping doctors diagnose and treat lung cancer were released today at the 1st European Lung Cancer Conference jointly organized by the European Society for Medical Oncology (ESMO) and the International Association for the Study of Lung Cancer (IASLC) in... view more (2008-04-28)

Two suppressor molecules affect 70 genes in leukemia
By restoring two small molecules that are often lost in chronic leukemia, researchers were able to block tumor growth in an animal model.   view more (2008-04-25)

Tiny RNA molecules fine-tune the brain's synapses
Non-coding regions of the genome - those that don't code for proteins - are now known to include important elements that regulate gene activity.   view more (2006-01-19)

Brain tissue reveals possible genetic trigger for schizophrenia
A study led by scientists from the University of North Carolina at Chapel Hill may have identified a molecular mechanism involved in the development of schizophrenia.   view more (2007-03-29)

UC Davis researchers identify a cellular pathway that makes prostate cancer fatal
Expanding evidence that tiny strands of RNA - called microRNAs - play big roles in the progress of some cancers, UC Davis researchers have identified one that helps jump start prostate cancer cell growth midway through the disease process, eventually causing it to become fatal.   view more (2007-11-28)

Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs
Researchers at Columbia University Medical Center have illuminated a window into how abnormalities in microRNAs, a family of molecules that regulate expression of numerous genes, may contribute to the behavioral and neuronal deficits associated with schizophrenia and possibly other brain disorders.   view more (2008-05-12)

Pair of microRNA molecules controls major oncogene in most common leukemia
Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world.   view more (2006-12-18)

Small RNAs can prevent spread of breast cancer
Howard Hughes Medical Institute researchers have identified small pieces of ribonucleic acid (RNA) that suppress the spread of breast cancer to the lungs and bone. The new research shows that the most invasive and aggressive human breast cancer tumors are missing three critical microRNA molecules.   view more (2008-01-10)

MicroRNAs help zebrafish regenerate fins
Biologists have discovered a molecular circuit breaker that controls a zebrafish's remarkable ability to regrow missing fins, according to a new study from Duke University Medical Center.   view more (2008-03-17)

Not just humans benefit from animal biotechnology
Laboratory animals are the source of major discoveries and breakthroughs in biology, not just in tackling disease but also unravelling fundamental molecular processes. Delegates at a recent research conference organised by the European Science Foundation (ESF) and Wellcome Trust heard how... view more (2007-10-25)

New genetic marker characterizes aggressiveness of cancer cells
Levels of a small non-coding RNA molecule called let-7 appear to define different stages of cancer better than some of the "classical" markers for tumor progression.   view more (2007-06-26)

Flip-Flopped Chromosome Reveals a First Clue to Tourette Syndrome
Researchers have identified the first gene mutation associated with Tourette syndrome-opening a new avenue for understanding the complex disorder that causes muscle and vocal tics.   view more (2005-10-14)
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