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MicroRNA processing and cancer
In an upcoming G&D paper, Dr. Scott Hammond (UNC-Chapel Hill) and colleagues describe a key regulatory step during microRNA biogenesis, which may underlie alterations of microRNA expression in cancer. view more (2006-08-01)
Lung cancer suppresses miR-200 to invade and spread
Primary lung cancer shifts to metastatic disease by suppressing a family of small molecules that normally locks the tumor in a noninvasive state, researchers at The University of Texas M. D. Anderson Cancer Center report in the Sept. 15 edition of Genes and Development. view more (2009-09-15)
Gladstone scientists identify single microRNA that controls blood vessel development
Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs. view more (2008-08-12)
Scientists discover small RNAs that regulate gene expression and protect the genome
RNA is best known as a working copy of the DNA sequence of genes. In this role, it's a carrier of the genes' instructions to the cell, which manufactures proteins according to information in the RNA molecule. view more (2008-05-14)
Study finds genes that 'fine-tune' muscle development process
Scientists at the University of North Carolina at Chapel Hill have found two genes that are essential for the proper development of muscle. view more (2005-12-30)
Scientists complete DNA sequencing and analysis of multiple fruit fly genomes
In one of the first large-scale comparisons of multiple animal genomes, scientists at the Broad Institute of MIT and Harvard, the Computer Science and Artificial Intelligence Laboratory (CSAIL) at MIT, and many collaborating institutions, have analyzed the genomes of twelve species of the fruit fly Drosophila to reveal insights on the evolution of... view more... (2007-11-08)
MicroRNA gene that regulates lifespan found by Yale scientists
Genes that control the timing of organ formation during development also control timing of aging and death, and provide evidence of a biological timing mechanism for aging, Yale researchers report in the journal Science. view more (2005-12-23)
Study shows microRNA-based diagnostic identifies squamous lung cancer with 96 percent sensitivity
A new study shows for the first time that a microRNA-based diagnostic test can objectively identify squamous lung cancer with 96% sensitivity, according to Harvey Pass, M.D. of the NYU Cancer Institute at NYU Langone Medical Center, one of the authors of the study published on-line ahead of print in the Journal of Clinical Oncology. view more (2009-03-10)
Biologists develop genome-wide map of miRNA-mRNA interactions
Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans). view more (2006-03-09)
Stem cell protein offers a new cancer target
A protein abundant in embryonic stem cells is now shown to be important in cancer, and offers a possible new target for drug development, report researchers from the Stem Cell Program at Children's Hospital Boston. view more (2009-06-02)
Texas A&M researchers find new mechanism for circadian rhythm
Molecules that may hold the key to new ways to fight cancer and other diseases have been found to play an important role in regulating circadian rhythm, says Liheng Shi, a researcher in Texas A&M's Department of Veterinary Integrative Biosciences. view more (2009-10-21)
Twin molecular scissors link creation of microRNAs with gene-silencing
One of the body's primary strategies for regulating its genome is a kind of targeted gene silencing orchestrated by small molecules called microRNAs, or miRNAs. view more (2005-11-04)
Yale scientists show that a microRNA can reduce lung cancer growth
A small RNA molecule, known as let-7 microRNA (miRNA), substantially reduced cancer growth in multiple mouse models of lung cancer, according to work by researchers at Yale University and Asuragen, Inc., published in the journal Cell Cycle. view more (2008-03-24)
Jefferson, Ohio State team find gene signature profile for metastasis
A common signature of tiny, specific pieces of non-coding genetic material known as microRNAs (miRNAs) may be directly involved in the spread of cancer to other parts of the body. view more (2008-06-02)
Jefferson researchers uncover genetic signature that predicts colon cancer
Researchers at Jefferson Medical College in Philadelphia have uncovered a genetic "signature" that accurately identifies colon cancer-a key, they hope, to better understand how the cancer develops. view more (2006-04-05)
New genetic techniques to combat lung cancer
New results on genetic techniques that are helping doctors diagnose and treat lung cancer were released today at the 1st European Lung Cancer Conference jointly organized by the European Society for Medical Oncology (ESMO) and the International Association for the Study of Lung Cancer (IASLC) in Geneva, Switzerland. view more (2008-04-28)
Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels
A newly discovered mechanism controls whether muscle cells in blood vessels hasten the development of both atherosclerosis and Alzheimer's disease, according to an article published online today in the journal Nature. view more (2009-07-06)
Experimental agent reduces breast cancer metastasis to bone
Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer. view more (2009-11-04)
Tiny genes may increase cancer susceptibility, Jefferson scientists find
New evidence indicates that small pieces of noncoding genetic material known as microRNAs (miRNAs) might influence cancer susceptibility. view more (2007-05-24)
Molecular steps involved in the creation of gene-silencing MicroRNAs identified
First discovered only a few brief years ago, microRNAs are small, remarkably powerful molecules that appear to play a pivotal role in gene silencing, one of the body's main strategies for regulating its genome. A scant 22 nucleotides in length, miRNAs appear to work by binding to and somehow interfering with messenger RNA, itself responsible for... view more... (2005-06-23)
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