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Cellular organelle evolved repeatedly
NWO researchers have discovered that in the course of evolution hydrogenosomes repeatedly evolved from mitochondria. Hydrogenosomes, or 'hydrogen-forming organelles', are cell organelles that produce hydrogen and energy. They serve as an alternative energy supply in organisms that live without oxygen, such as anaerobic fungi and protozoa. The... view more... (2001-07-26)
Protein transport in mitochondria revealed
The TIM23 complex, which regulates the transport of protein to the mitochondria in a cell, is much more complicated than was previously believed. This is shown by Uppsala University researcher Maria Lind in an article in the leading journal Cell. view more (2005-03-31)
New research helps explain genetics of Parkinson's disease
A new study by Narendra et al. suggests that Parkin, the product of the Parkinson's disease-related gene Park2, prompts neuronal survival by clearing the cell of its damaged mitochondria. view more (2008-11-24)
Topical Papers in Biochemical Journal - Selective determination of mitochandrial chelatable iron in viable cells with a new fluorescent sensor
This paper by Petrat and colleagues marks an important advance in our understanding of the regulation of iron in the human body. Real-time changes in the concentration of the ionized form of iron (Fe2+) can now be monitored within the mitochondria of living cells for the first time, thanks to the technique described in this article. For some... view more... (2002-02-08)
Bad mitochondria may actually be good for you
Mice with a defective mitochondrial protein called MCLK1 produce elevated amounts of reactive oxygen when young; that should spell disaster, yet according to a study in this week's JBC these mice actually age at a slower rate and live longer than normal mice. view more (2009-07-23)
Unstable proteins can cause premature ageing
The normal ageing process has long been linked to problems with cell respiration, the process through which the cells extract energy from nutrients. view more (2009-08-06)
New clues about mitochondrial 'growth spurts'
Mitochondria are restless, continually merging and splitting. But contrary to conventional wisdom, the size of these organelles depends on more than fusion and fission, as Berman et al. show. Mitochondrial growth and degradation are also part of the equation. view more (2009-03-02)
Lighting up the heart
A major breakthrough in research could lead to improved recovery of the heart when it is re-started after a heart attack or cardiac surgery. view more (2006-09-22)
Forecasting Heart Storms
The requirements of man to the weather forecast are changing before our eyes. Before, a temperature, precipitation and wind forecast could do, while now man want to know the condition of the electromagnetic field of the Earth in a month ahead, desirably. Those, who suffer from heart diseases, are the ones to worry most of all: cardio-vascular... view more... (2002-04-02)
Fat-generated hormone drives energetic capacity of muscle
The fat-generated hormone adiponectin plays an important role in the energetic capacity of skeletal muscle, according to a new study in the July, 2006, Cell Metabolism. view more (2006-07-06)
Researchers develop marker that identifies energy-producing centers in nerve cells
A protein that causes coral to glow is helping researchers at the University of Maryland School of Medicine to light up brain cells that are critical for the proper functioning of the central nervous system. view more (2007-02-02)
Defective movement of cell's power plants implicated in commom inherited neurological disorder
Contrary to previous thinking, the inefficient movement of cell's "power plants" -- the mitochondria -- within a cell, rather than their low energy production, may be a contributing factor in the development of Charcot-Marie-Tooth disease (CMT), new research shows. view more (2007-01-17)
Reduced mitochondrial function important mechanism in aging
Scientists at the Karolinska Institute have found that changes in the "powerhouse" of cells, the mitochondria, play a key role in aging. The findings are being published in this week's issue of the journal Nature. Mitochondria, which provide energy to cells, have their own set of DNA. Mutations of mitochondrial DNA increase with age,... view more... (2004-05-27)
Nixing immaturity in red blood cells
A process of self-digestion called autophagy prompts the maturation of red blood cells. Without a protein called Nix, the cells would not effectively rid themselves of organelles called mitochondria and consequently become short-lived, leading to anemia, said researchers at Baylor College of Medicine in Houston in a report that appears online... view more... (2008-05-05)
Sidestepping cancer's chaperone
Cancerous tumors are wildly unfavorable environments. Struggling for oxygen and nutrients while being bombarded by the body's defense systems, tumor cells in fact require sophisticated adaptations to survive and grow. view more (2007-10-22)
A link between mitochondria and tumor formation in stem cells
Researchers report on a previously unknown relationship between stem cell potency and the metabolic rate of their mitochondria -a cell's energy makers. Stem cells with more active mitochondria also have a greater capacity to differentiate and are more likely to form tumors. view more (2008-10-13)
Cancer cells 'reprogram' energy needs to grow and spread, study suggests
Studying a rare inherited syndrome, researchers at Johns Hopkins have found that cancer cells can reprogram themselves to turn down their own energy-making machinery and use less oxygen, and that these changes might help cancer cells survive and spread. view more (2007-05-08)
Nerve cells' power plants caught in a traffic jam
Nerve cells need lots of energy to work properly, and the energy needs to be delivered to the right place at the right time. By inducing a mutation in fruit flies, researchers have figured out that a particular gene governs the movement of cells' energy-producing units, called mitochondria. view more (2005-08-05)
A new brake on cellular energy production discovered
A condition that has to be met for the body to be able to keep warm, move and even survive is that the mitochondria - the cells' power stations - release the right amounts of energy. view more (2007-07-27)
Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection
As the major source of free radicals in cells, mitochondria contribute to the high levels of oxidative stress believed to play a role in the pathogenesis of Alzheimer's disease. view more (2008-04-07)
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