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Understanding the Noxious cause of Lou Gehrig's disease
There is no known cure for amyotrophic lateral sclerosis (ALS), often known as Lou Gehrig disease and motor neuron disease.   view more (2007-09-14)

Genetics of ALS progression
An upcoming paper from Drs. Hidenori Ichijo and Hideki Nishitoh (The University of Tokyo) and colleagues lends new and valuable insight into the genetics of ALS.   view more (2008-06-02)

Drug blocks lethal motor-neuron disease in mice
Spinal muscular atrophy (SMA) is an inherited motor-neuron disease that, in its most severe form, leads to death before 2 years of age and for which there is no treatment.   view more (2007-02-23)

Discovery of agile molecular motors could aid in treating motor neuron diseases
Over the last several months, the labs of Yale Goldman, MD, PhD, Director of the Pennsylvania Muscle Institute at the University of Pennsylvania School of Medicine, and Erika Holzbaur, PhD, Professor of Physiology, have published a group of papers that, taken together, show proteins that function... view more (2006-07-18)

Researchers identify a gene responsible for cases of Lou Gehrig's disease
A team of Canadian and French researchers has identified a novel gene responsible for a significant fraction of ALS (sporadic amyotrophic lateral sclerosis) cases. ALS is commonly referred to as Lou Gehrig's disease, an incurable neuromuscular disorder that affects motor neurons and leads to... view more (2008-04-01)

Growth factor stimulates rapid extension of key motor neurons in brain
A growth factor known to be important for the survival of many types of cells stimulates rapid extension of corticospinal motor neurons - critical brain cells that connect the cerebral cortex with the spinal cord and that die in motor neuron diseases like amyotrophic lateral sclerosis (ALS or Lou... view more (2006-11-06)

Targeting astrocytes slows disease progression in ALS
In what the researchers say could be promising news in the quest to find a therapy to slow the progression of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, scientists at the University of California, San Diego (UCSD) School of Medicine have shown that targeting neuronal support... view more (2008-02-04)

Lightning and electric shocks may increase risk of motor neurone disease
Some cases of motor neurone disease may be sparked by an electric shock or lightning, suggests research in the Journal of Neurology, Neurosurgery, and Psychiatry. Motor neurone disease is a progressive degenerative disorder, which eventually results in paralysis of muscles in the body. At present,... view more (2001-07-18)

Stem cells provide new tool for studying disease and identifying ALS drugs
Results of two studies funded by Project A.L.S. and appearing in today's advance online publication of Nature Neuroscience demonstrate that embryonic stem cells may provide a new tool for studying disease mechanisms and for identifying drugs to slow ALS, also known as Lou Gehrig's disease.   view more (2007-04-17)

Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons
Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with amyotropic lateral sclerosis (ALS), or Lou Gehrig's disease.   view more (2008-06-17)

New roles for growth factors: Enticing nerve cells to muscles
During embryonic development, nerve cells hesitantly extend tentacle-like protrusions called axons that sniff their way through a labyrinth of attractive and repulsive chemical cues that guide them to their target.   view more (2006-06-16)

Silence the gene, save the cell: RNA interference as promising therapy for ALS
Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of... view more (2005-03-09)

Motor neuron disease and toxic substances: Possible link?
Motor neuron disease is a rare, devastating illness in which nerve cells that carry brain signals to muscles gradually deteriorate. One form of it, Lou Gehrig's disease or ALS (amyotrophic lateral sclerosis), is familiar to the public in the lives of scientist Stephen Hawking and Morrie Schwartz,... view more (2008-03-24)

New therapeutic insight into duchenne muscular dystrophy
In the April 1st issue of Genes & Development, Dr. Bruce Spiegelman (Dana Farber Cancer Institute) and colleagues identify a key genetic component of and possible therapeutic target for Duchenne muscular dystrophy.   view more (2007-04-02)

Case biologists show that what a neuron can do is a function of mechanical context
The brain as command center for bodily movement was too simple an idea, thought the Russian physiologist Nicolas Bernstein some 60 years ago.   view more (2006-02-08)

Insight into dopamine role suggests new treatment pathway for Parkinson's
Dopamine (DA) not only functions as a neurotransmitter, a chemical messenger between neurons by which one neuron triggers another, researchers have found.   view more (2006-10-19)

Neural signal that helps wire up brain's movement circuit identified
Scientists from Imperial College London and King`s College London have identified a molecule that helps to wire up the neural circuitry responsible for controlling the movement of muscle. Writing today in the journal Neuron, the researchers describe how the signalling protein named WNT-3 directs... view more (2002-09-10)

Learned motor programs directly influence the visual perception of movements
When novel movements are learned-for example, in sports-visual and motor learning take place simultaneously.   view more (2006-01-10)

UCLA researchers show that culture influences brain cells
A thumb's up for "I'm good." The rubbing of a pointed forefinger at another for "shame on you." The infamous and ubiquitous middle finger salute for-well, you know.   view more (2007-07-18)

Glaucoma patients at significantly higher risk for falls, motor vehicle accidents
Persons affected by glaucoma are over three times more likely to have been involved in falls and motor vehicle accidents than persons of the same age without the condition, say researchers from Dalhousie University in Canada.   view more (2007-03-01)

Study suggests new treatments for Huntington's disease
Working with fruit flies, researchers have discovered a new mechanism by which the abnormal protein in Huntington's disease causes neurodegeneration.   view more (2008-01-10)

Umbilical cord blood cell transplants may help ALS patients
A study at the University of South Florida has shown that transplants of mononuclear human umbilical cord blood (MNChUCB) cells may help patients suffering from Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease.   view more (2008-06-25)

Fine motor skills, social acceptance lower in children with 'lazy eye'
A recent study evaluating the fine motor skills and perceived self esteem of children with amblyopia (or "lazy eye") compared with age-matched children will be presented during the Association for Research in Vision and Ophthalmology (ARVO) 2007 Annual Meeting in Fort Lauderdale, Fla.   view more (2007-05-09)

Understanding Fragile X syndrome with the blink of an eye
While researchers have long known the genetic defect underlying Fragile X syndrome, they are still tracing how that defect creates the complex mix of mental retardation, hyperactive behavior, attention deficits, and other problems in the disorder.   view more (2005-08-04)

Treating sleep disorders would reduce risk of serious motor vehicle crashes
Sleep related accidents comprise 15-20% of all motor vehicle crashes, resulting in thousands of serious injuries and death. Yet a study published in Thorax confirms that treatment of patients with sleep apnoea would reduce their risk of serious motor vehicle crashes to a rate similar to the general... view more (2001-06-14)
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