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Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle
A new study by University of Pennsylvania School of Medicine shows, for the first time in humans, that ventilators combined with diaphragm disuse contributes to muscle atrophy in the diaphragm in as little as eighteen hours.   view more (2008-03-27)

Muscle atrophy through thick but not thin
During desperate times, such as fasting, or muscle wasting that afflicts cancer or AIDS patients, the body cannibalizes itself, atrophying and breaking down skeletal muscle proteins to liberate amino acids.   view more (2009-06-08)

Mutation responsible for cystic fibrosis also involved in muscle atrophy
Patients with cystic fibrosis (CF) usually experience significant muscle loss, a symptom traditionally considered to be a secondary complication of the devastating genetic disease.   view more (2009-07-31)

Purdue researchers find 'switch' for skeletal-muscle atrophy
Researchers in Purdue University's School of Veterinary Medicine have discovered genetic and drug-treatment methods to arrest the type of muscle atrophy often caused by muscle disuse, as well as aging and diseases such as cancer.   view more (2006-05-25)

MU logo News Bureau University of Missouri About the News Bureau Contact Us Home / News Releases / 2009 MU Researchers Discover Target that Could Ease Spinal Muscular Atrophy Symptoms
There is no cure for spinal muscular atrophy (SMA), a genetic disorder that causes the weakening of muscles and is the leading genetic cause of infant death, but University of Missouri researchers have discovered a new therapeutic target that improves deteriorating skeletal muscle tissue caused by SMA. The new therapy enhanced muscle strength,... view more... (2009-01-08)

Study Examines Role of Helicobacter Pylori in Esophageal Cancer Development
Infection with bacteria that can cause peptic ulcers and distal stomach cancer may be associated with a reduced risk of a type of esophageal cancer called adenocarcinoma, according to a study in the March 3 issue of the Journal of the National Cancer Institute. However, that same study found that people infected with the bacteria, called... view more... (2004-03-03)

Human muscle-derived stem cells effective in animal models of incontinence
Human muscle-derived cells, pluripotent stem cells found in muscle, have been used to cure stress urinary incontinence in animal models, a finding which signals that these cells are prime candidates to treat the condition in adults.   view more (2005-09-01)

Mice models developed at UCSD to benefit patients with multiple system atrophy
Researchers at the University of California, San Diego (UCSD) School of Medicine have developed a series of transgenic mouse models of multiple system atrophy, a progressive, fatal neurological disorder.   view more (2005-11-17)

Molecular Therapy for Spinal Muscular Atrophy Closer to Clinical Use
Spinal muscular atrophy, a neurodegenerative disorder that causes the weakening of muscles, is the leading cause of infant death and occurs in 1 in 6,000 live births.   view more (2008-12-17)

Scientists identify gene responsible for statin-induced muscle pain
Statins, the popular class of drugs used to lower cholesterol, are among the most commonly prescribed medications in developed countries.   view more (2007-11-28)

Mimicking a human disease in mice: a new model for the Parkinson related illness multiple system atrophy
In this month`s issue of EMBO Reports Kahle et al. describe how they genetically engineered a mouse to show pathological symptoms similar to those of human patients suffering from the neural disease Multiple System Atrophy (MSA), also known as Shy-Drager-Syndrome. The model could help researchers to develop and test new efficient drugs against... view more... (2002-06-06)

MRI shows brain atrophy pattern that predicts Alzheimer's
Using special MRI methods, researchers have identified a pattern of regional brain atrophy in patients with mild cognitive impairment (MCI) that indicates a greater likelihood of progression to Alzheimer's disease. The findings are published in the online edition of Radiology.    view more (2009-02-10)

As Good As It Gets: Octogenarian Muscles Don't Get Stronger With Exercise
Octogenarian women were unable to increase muscle mass after a 3-month weight lifting program targeted at strengthening the thigh muscle, according to a new study from the Journal of Applied Physiology.   view more (2009-03-31)

Penn researchers gain new insights on spinal muscular atrophy
Researchers from the University of Pennsylvania School of Medicine discovered that the effect of a protein deficiency, which is the basis of the neuromuscular disease spinal muscular atrophy (SMA), is not restricted to motor nerve cells, suggesting that SMA is a more general disorder.   view more (2008-05-30)

ISU researchers find possible treatment for Spinal Muscular Atrophy
Spinal Muscular Atrophy is the second-leading cause of infant mortality in the world.    view more (2009-07-28)

Reduced brain volume may predict dementia in healthy elderly people
Reduced volume, or atrophy, in parts of the brain known as the amygdala and hippocampus may predict which cognitively healthy elderly people will develop dementia over a six-year period.   view more (2006-01-03)

Genetic test for spinal muscular atrophy should be offered to all couples, says the ACMG
Carrier screening for spinal muscular atrophy (SMA)-a serious genetic disease affecting approximately 1 in 10,000 infants that causes progressive muscle weakness and death-should be made available to all families, according to a new practice guideline issued by the American College of Medical Genetics (ACMG).   view more (2008-12-10)

Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
During muscle regeneration, which is a natural response to injury and disease, environmental cues cause adult muscle stem cells (satellite cells) to shift from dormancy to actively building new muscle tissue.   view more (2007-12-10)

Scientists discover possible new treatment for genetic diseases
Scientists from Imperial College London, the University of Leicester, and Hammersmith Hospital have found a way to stop certain types of genetic diseases from occurring by modifying the way DNA is turned into proteins. The research published in this month's Proceedings of the National Academy of Science shows how the researchers have been able to... view more... (2003-03-14)

NEW MAPPING TECHNIQUE FOR EARLIER DETECTION OF ALZHEIMER’S DISEASE (p 201)
An Early Report in this week’s issue of THE LANCET outlines an imaging technique that could identify the early progression of Alzheimer’s disease before the onset of clinical symptoms. The early diagnosis and monitoring of the progression of Alzheimer’s disease is important for the development of therapeutic strategies aimed at... view more... (2001-07-18)
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