Mutated Protein Current Events | Mutated Protein News
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Enzyme fights mutated protein in inherited Parkinson's disease
An enzyme that naturally occurs in the brain helps destroy the mutated protein that is the most common cause of inherited Parkinson's disease, researchers at UT Southwestern Medical Center have found. view more (2009-06-26)
Promising new treatment for Alzheimer's suggested based on Hebrew University research
Research carried out at the Hebrew University of Jerusalem has resulted in a promising approach to help treat Alzheimer's disease in a significant proportion of the population that suffers from a particularly rapid development of this disease. view more (2009-07-21)
Enzyme fights mutated protein in inherited Parkinson's disease
An enzyme that naturally occurs in the brain helps destroy the mutated protein that is the most common cause of inherited Parkinson's disease, researchers at UT Southwestern Medical Center have found. view more (2009-06-29)
Worth a thousand words: Hopkins researchers paint picture of cancer-promoting culprit
They say that a picture can be worth a thousand words. This especially is true for describing the structures of molecules that function to promote cancer. Researchers at Johns Hopkins have built a three-dimensional picture of an enzyme often mutated in many types of cancers. view more (2008-01-07)
Cancer-Causing Protein Can Also Help Fight the Tumors It Causes
Oncogenes are genes that when mutated or expressed in high concentrations can cause normal cells to become cancerous. view more (2009-06-19)
Mouse model for schizophrenia has genetic on-off switch
Scientists at Johns Hopkins have developed a mouse model for schizophrenia in which a mutated gene linked to schizophrenia can be turned on or off at will. view more (2007-09-11)
More genes for Lou Gehrig's disease identified, according to Penn researchers
In recent months a spate of mutations have been found in a disease protein called TDP-43 that is implicated in two neurodegenerative disorders: amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, and certain types of frontotemporal dementia (FTD). These mutations could potentially become candidates for drug targets. view more (2008-04-08)
Thyroid cancer discovery points to new treatments, prevention
The actions of a mutated protein in cells linked to thyroid cancer have been uncovered by researchers at Queen's University. view more (2006-11-16)
Novel regulation of the common tumor suppressor PTEN
PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation and survival processes. When mutated or deleted, it causes cancers of the prostate, breast, colon, and brain. view more (2007-01-12)
New Cancer Treatment Targets Both Tumor Cells and Blood Vessels
It takes more than one punch to fight tumors. Often, tumors have more than one way of surviving, and attacking the tumor alone is not enough. view more (2008-06-19)
Colorectal cancer : A new way of increasing the efficacy of chemotherapy
Inserm and CNRS research scientists and doctors at the Institut Curie have demonstrated the influence of the status - mutated or functional - of the tumour suppressor gene p53 in the response of colorectal cancer to chemotherapy. Tumours in which the p53 gene is mutated respond less well to treatment. However, by adding another agent, researchers... view more... (2004-02-27)
Researchers discover cell's 'quality control' mechanism
Researchers in Japan and Canada have discovered a key component of the quality control mechanism that operates inside human cells - sometimes too well. The breakthrough has significant implications for the development of new treatments for cystic fibrosis (CF) and some other hereditary diseases, the researchers say. Their results were published... view more... (2008-07-30)
Stabilizing cancer-fighting p53 can also shield a metastasis-promoter
Efforts to protect the tumor-suppressor p53 could just as easily shelter a mutant version of the protein, causing cancer cells to thrive and spread rather than die, according to research by scientists at The University of Texas M. D. Anderson Cancer Center reported in the current issue of the journal Genes and Development. view more (2008-05-23)
Genome update defines landscape of breast and colon cancers
One year after completing the first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center scientists have studied the vast majority of protein-coding genes which now suggest a landscape dominated by genes that each are mutated in relatively few cancers. view more (2007-10-12)
Solving the mystery of mutated proteins and the brain
In some neurological diseases, too much of what is usually a good thing can be bad, said researchers at Baylor College of Medicine in a report in this week's issue of the journal Cell. view more (2005-08-26)
Protein binds whenever it can
Dutch cancer researcher Joost Martens has discovered that the protein p300, which plays an important role in the correct transcription of DNA to RNA, can bind to DNA at several sites. The protein can also occupy a position in various complexes, each with its own protein composition. This knowledge is important for gaining a better understanding of... view more... (2003-06-24)
Study reveals how some molecules inhibit growth of lung cancer cells
By mapping the interlocking structures of small molecules and mutated protein "receptors" in non-small cell lung cancer (NSCLC) cells, scientists at Dana-Farber Cancer Institute and their colleagues have energized efforts to design molecules that mesh with these receptors, potentially interfering with cancer cell growth and survival. view more (2007-03-13)
Protein-protein interaction explains vision loss in genetic diseases
The mystery of genetic disease is only partially solved with the identification of a mutated gene. Often, the pattern of disease - the features or disorders associated with it - vary in type and severity among those who are affected. Scientists, physicians and patients all ask why. view more (2009-05-11)
New insight into Alzheimer's disease pathology
An Alzheimer's-related protein helps form and maintain nerve cell connections, according to a study published in the May 4 print issue of the Journal of Cell Biology and online at www.jcb.org. view more (2009-05-04)
Dual functions of gene revealed, for better and for worse
Researchers at WEHI have pinpointed the function of a potent cancer gene. The gene, known as "ERG", has long been associated with a range of human malignancies, including leukemia and sarcoma. American scientists showed in 2005 that ERG is mutated in more than half of all prostate cancers. view more (2008-05-27)
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