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HIV is a 'double hit' to the brain
New evidence reported in the August issue of Cell Stem Cell, a publication of Cell Press, offers a novel perspective on how the HIV/AIDS virus leads to learning and memory deficits, a condition known as HIV-associated dementia.   view more (2007-08-16)

The Lancet Neurology November Issue Press Release
NO SEX PLEASE, WE`RE BRITISH (NEUROLOGISTS) It is well known in media circles that including the word "sex" in a headline is a sure-fire way of attracting the attention of potential readers. It is understandable, therefore, why a paper published in the Journal of Neurology, Neurosurgery,... view more (2002-10-16)

Scientists encourage cells to make a meal of Huntington's disease
Scientists have developed a novel strategy for tackling neurodegenerative diseases such as Huntington's disease: encouraging an individual's own cells to "eat" the malformed proteins that lead to the disease.   view more (2007-05-08)

Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons
Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with amyotropic lateral sclerosis (ALS), or Lou Gehrig's disease.   view more (2008-06-17)

Promising new drug targets identified for Huntington's disease
Research funded by the Wellcome Trust has provided a number of promising new drug targets for Huntington's disease, a neurodegenerative disease. Scientists at the University of Cambridge have identified a number of candidate drugs to investigate further which encourage cells to "eat" the... view more (2008-03-24)

MIT zeroes in on Alzheimer's structures
MIT engineers report a new approach to identifying protein structures key to Alzheimer's disease, an important step toward the development of new drugs that could prevent such structures from forming.   view more (2008-08-22)

'Intrabody' can mop up mutant protein in Huntington's disease model
Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. Emory University researchers engineered a virus to make an intracellular antibody or "intrabody" against huntingtin, the protein whose mutant forms poison the... view more (2008-05-27)

Research suggests cause of neurodegeneration in Huntington's disease
The severe neurodegeneration associated with Huntington's disease may result from molecular mutations that block the transport of nutrients within cells.   view more (2006-05-31)

Protein sensor for fatty acid buildup in mitochondria
Just as homes have smoke detectors, cells have an enzyme that responds to a buildup of fatty acids by triggering the production of a key molecule in the biochemical pathway that breaks down these fatty acids, according to investigators at St. Jude Children's Research Hospital.   view more (2007-02-15)

Deadly genetic disease prevented before birth in zebrafish
By injecting a customized "genetic patch" into early stage fish embryos, researchers at Washington University School of Medicine in St. Louis were able to correct a genetic mutation so the embryos developed normally.   view more (2008-03-24)

The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases
A phenomenon considered healthy for cells, such as the accumulation of long chains of glucose (glycogen), which tissues store for energy purposes, is harmful for neurons.   view more (2007-10-22)

Study links Alzheimer's disease to abnormal cell division
A new study in mice suggests that Alzheimer's disease (AD) may be triggered when adult neurons try to divide. The finding helps researchers understand what goes wrong in the disease and may lead to new ways of treating it.   view more (2006-01-18)

Researchers find connection between caloric restriction and longevity
For nearly 70 years scientists have known that caloric restriction prolongs life. In everything from yeast to primates, a significant decrease in calories can extend lifespan by as much as one-third. But getting under the hood of the molecular machinery that drives this longevity has remained... view more (2007-09-21)

Top-rung research environments singled out
A panel of acknowledged international experts has identified Sweden's foremost environments for basic research. The Swedish Research Council will be able to finance ten of the 27 research environments of excellence that have been winnowed from 261 applications. These research teams are from all... view more (2005-02-17)

International scientists tackle obstacles to treating brain disorders
A research team led by scientists at the University of Minnesota Medical School and Oregon Health & Science University have outlined the challenges and made suggestions on how to advance research and improve treatments for brain disorders.   view more (2007-12-21)

Blocking immune cell action increases Alzheimer's-associated protein deposits
The immune system's response against amyloid-beta, the protein that forms plaques in the brains of patients with Alzheimer's disease, appears to protect the brain from damage in early stages of the devastating neurological disorder.   view more (2007-03-28)

Cell death in sparrow brains may provide clues in age-related human diseases
A remarkable change takes place in the brains of tiny songbirds every year, and some day the mechanism controlling that change may help researchers develop treatments for age-related degenerative diseases of the brain such as Parkinson's and dementia.   view more (2007-09-18)

Finding a cellular Neverland: How stem cells stay childlike
espite their celebrated "immortality," the capacity of embryonic stem (ES) cells for endless division has its limits. After a very extended childhood spent dividing in a culture dish, even stem cells tend to grow up and assume adult roles as workaday nerve, muscle, or blood cells, never... view more (2006-06-27)

DNA repair proteins monitored at double-strand break
Investigators at St. Jude Children's Research Hospital had a molecule's eye view of the human cell's DNA repair kit as it assembled on a double-strand break to link together the broken ends.   view more (2007-05-10)
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