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A glimmer of hope in the struggle against neurodegenerative diseases: the virtues of proteins that can save dying neurons
Diseases characterized by neurodegeneration affect individuals over 50 years of age and they attack one particular class of neurons in the brain or spinal cord. The research interest of Professor Ann Kato and her team is principally focalized on ALS in which there is a progressive paralysis caused... view more (2002-01-25)

Overexcited neurons not good for cell health
Neurotransmitters have consequences. They initiate events that are critical to a healthy life, giving us the ability to move, to talk, to breathe, to think. But that's if the neurotransmitters are getting it right and sending proper signals downstream to muscle cells, neurons or other cells.   view more (2007-12-18)

Iron-moving malfunction may underlie neurodegenerative diseases, aging
A glitch in the ability to move iron around in cells may underlie a disease known as Type IV mucolipidosis (ML4) and the suite of symptoms---mental retardation, poor vision and diminished motor abilities---that accompany it, new research at the University of Michigan shows.   view more (2008-09-23)

St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
Investigators at St. Jude Children's Research Hospital have identified the cell that gives rise to the eye cancer retinoblastoma, disproving a long-standing principle of nerve growth and development.   view more (2007-10-19)

Newborn neurons like to hang with the 'in' crowd
Like any new kid on the block that tries to fit in, newborn brain cells need to find their place within the existing network of neurons.   view more (2007-05-08)

Blood transfusion-transmitted infections: A global perspective
Thanks to the many blood-safety interventions introduced since 1984, the overall risk for most transfusion-transmitted infections has become exceedingly small.   view more (2006-09-28)

Seven UK cases of Creutzfeldt-Jakob disease associated with transplanted human tissue
Seven cases of Creutzfeldt-Jakob disease (CJD) associated with transplanted human tissue have occurred in the UK over a period of 33 years, reveals a study published ahead of print in the Journal of Neurology Neurosurgery and Psychiatry.   view more (2006-04-20)

Purdue scientists may have found key to halting spinal cord damage
Purdue University researchers may have isolated the substance most responsible for the tissue damage that follows initial spinal cord injury, a discovery that could also improve treatments for a host of other neurodegenerative conditions.   view more (2005-06-21)

Neurotherapeutics presents special issue on new treatments for Alzheimer's disease
The editors of Neurotherapeutics are pleased and proud to announce their July issue, devoted to "Novel Therapeutics for Alzheimer's Disease."   view more (2008-07-25)

Not all embryonic stem cell lines are created equal
When it comes to generating neurons, researchers have found that not all embryonic stem (ES) cell lines are equal. In comparing neurons generated from two NIH-approved embryonic stem cell lines, scientists have uncovered significant differences in the mature, functioning neurons generated from each... view more (2007-08-07)

Is there more to prion protein than mad cow disease?
Prion protein, a form of protein that triggers BSE, is associated with other brain diseases in cattle, raising the possibility of a significant increase in the range of prion disease.   view more (2008-09-30)

Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease.   view more (2007-11-14)

Memantine appears effective and safe in moderate to severe Alzheimer's disease
Memantine, a drug approved for the treatment of Alzheimer disease, appears safe and effective in patients with moderate to severe cases of the condition, according to a study in the January issue of Archives of Neurology.   view more (2006-01-10)

Researchers find molecule that may hold key to learning and memory
Independent research teams from Harvard Medical School and Children's Hospital Boston have identified a master protein that sheds light on one of neurobiology's biggest mysteries-how neurons change as a result of individual experiences.   view more (2006-02-22)

A natural chemical found in strawberries boosts memory in healthy mice
Mothers have long exhorted their children to eat their fruit and vegetables. But once kids are beyond mom's watchful eye, the hated greens often go the way of Barbie dolls and power rangers. Now, there's another reason to reach for colorful fruits past adolescence.   view more (2006-10-18)

How the Neuron Sprouts Its Branches
Neurobiologists have gained new insights into how neurons control growth of the intricate tracery of branches called dendrites that enable them to connect with their neighbors.   view more (2005-12-12)

Gas-blockers might slow down Alzheimer's disease
A noxious gas speeds up brain degeneration in Alzheimer's disease, according to a study in the November 7 issue of The Journal of Experimental Medicine.   view more (2005-10-31)

Engineered stem cells show promise for sneaking drugs into the brain
One of the great challenges for treating Parkinson's diseases and other neurodegenerative disorders is getting medicine to the right place in the brain.   view more (2005-12-15)

Limitations of Current Evaluation Techniques for the Cost-Effectiveness of Treatments for Parkinson's Disease
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Pharmaceutical and surgical therapies for PD are available and can alleviate the symptoms and complications. Unfortunately, despite these therapies, the disease relentlessly progresses. A new study in the journal Value... view more (2004-11-10)

Study in mice suggests molecules in plants have beneficial effect on Alzheimer's disease
A set of molecules found in certain plants appears to have a beneficial effect in brain tissue associated with Alzheimer's disease, according to a new study conducted in mice. The study was led by researchers at the University of South Florida and Cedars-Sinai Medical Center. An article in the... view more (2008-05-07)

In scientific first, Einstein researchers correct decline in organ function associated with old age
As people age, their cells become less efficient at getting rid of damaged protein - resulting in a buildup of toxic material that is especially pronounced in Alzheimer's, Parkinson's disease, and other neurodegenerative disorders.   view more (2008-08-11)

New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease. "Our team has defined a second prion protein called 'Shadoo', that exists in addition to the well-known prion protein called 'PrP' " said Professor David Westaway, director of... view more (2007-08-17)

Mayo Clinic research collaboration discovers why some DNA repair fails
Mayo Clinic researchers have discovered the inner workings of a defective DNA repair process and are first to explain why certain mutations are not corrected in cells.   view more (2005-10-04)

Myelin suppresses plasticity in the mature brain
Yale School of Medicine researchers report in Science this week genetic evidence for the hypothesis that myelination, or formation of a protective sheath around a nerve fiber, consolidates neural circuitry by suppressing plasticity in the mature brain.   view more (2005-09-30)

Huntington's disease study shows animal models on target
An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntington's Disease (HD) closely resembles that of human HD patients.   view more (2007-08-01)
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