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Copper circuits help brain function — could tweaking the circuits make us smarter?
The flow of copper in the brain has a previously unrecognized role in cell death, learning and memory.   view more (2006-09-26)

Structure of important neurotransmitter regulator determined
Researchers from Virginia Tech and the Brookhaven National Laboratory have solved the structure of an enzyme that is critical in the regulation of the neurotransmitter system in the human brain.   view more (2008-02-04)

Free radical cell death switch identified
Humans and other organisms depend on oxygen to produce the energy required for cells to carry out their normal functions. A cell's engine, the mitochondria, converts oxygen into energy. But this process also leaves a kind of exhaust product known as free radicals.   view more (2006-06-02)

Coronary heart disease is under-diagnosed and under-treated in women
Coronary heart disease is under-diagnosed, under-treated, and under-researched in women, says a senior doctor in this week's BMJ.   view more (2005-09-02)

Rare disease's gene may illuminate major disorders
Oregon Health & Science University researchers have identified the gene behind a group of rare, progressive childhood disorders caused by an abnormal buildup of iron in the brain.   view more (2006-06-19)

Mammalian neurogenesis breaks into the most static brain region
ifteen years ago, the discovery of adult neurogenesis (the production of new neurons) in the highly static, non-renewable mammalian brain was a breakthrough in neuroscience.   view more (2008-06-04)

Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
A naturally occurring molecule in the body appears to control whether certain medications, such as beta adrenergic receptor agonists used in acute heart failure or in inhalers for asthma, lose their effectiveness over time.   view more (2007-05-04)

Journal Studies Find Relationship Between Delirium, Dementia
Dementia, including Alzheimer's disease, is one of the most devastating conditions of older age. Currently affecting nearly 7 million individuals in the U.S. and 24 million worldwide, dementia leads to total loss of memory and the ability to function independently-making it one of people's greatest... view more (2007-01-18)

High rate of complicated idiopathic gallstone disease in pediatric patients
The prevalence of gallstones in adults of industrialized countries is approximately 10% and is showing a tendency to rise. Data for pediatric patients is scarce.   view more (2008-04-30)

Different mutations in a single gene suggests Parkinson's disease is primarily an inherited genetic disorder
Two new international studies by researchers at the Mayo Clinic site in Florida are rounding out the notion that Parkinson's disease is largely caused by inherited genetic mutations that pass through scores of related generations over hundreds, if not thousands of years.   view more (2008-04-17)

Mutant mice show key autism traits
While the causes of autism remain complex and mysterious, researchers are steadily adding pieces to its intricate puzzle.   view more (2006-05-04)

Sphingolipids with therapeutic ends
Sphingolipids have been known for more than 120 years but, up to recently, they were thought to be molecules that simply complied with a structural function, acting, as it were, as the building blocks of the biological membranes.   view more (2007-03-05)

CAUTION IS NEEDED IN COMMERCIAL PARTNERSHIPS IN CARE MANAGEMENT
Thomas Bodenheimer, Clinical Professor at the Department of Family and Community Medicine, University of California at San Francisco, School of Medicine argues that commercial disease management programmes may take needed money away from actual caregiving in order to enhance companies? profits.... view more (2000-02-22)

Using Nanoparticles, In Vivo Gene Therapy Activates Brain Stem Cells
Using customized nanoparticles that they developed, University at Buffalo scientists have for the first time delivered genes into the brains of living mice with an efficiency that is similar to, or better than, viral vectors and with no observable toxic effect, according to a paper published this... view more (2005-07-26)

Same gene protects from 1 disease, opens door to another
Botanists at Oregon State University have discovered that a single plant gene can cause resistance to one disease at the same time it produces susceptibility to a different disease - the first time this unusual phenomenon has ever been observed in plants.   view more (2007-08-29)

New journal for the 21st century drug hunter launched
Drug discovery researchers will be able to keep up-to-date with the latest developments in therapeutic drug discovery with a new peer-reviewed journal, Current Opinion in Investigational Drugs, launched today (25 September) by PharmaPress Ltd. This monthly journal aims to provide a comprehensive... view more (2000-09-20)

All eukaryotic kinases share 1 common set of substrates
Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death.   view more (2007-08-22)

Genes influence both susceptibility to, and progression of, multiple sclerosis
Susceptibility to multiple sclerosis (MS), and the way in which the disease progresses, are genetically determined, suggests research in the Journal of Neurology Neurosurgery and Psychiatry.   view more (2001-11-23)

New gene uncovered for late-onset Alzheimer's
An international team of researchers, led by Columbia University Medical Center, Boston University School of Medicine and the University of Toronto, has uncovered a major new gene — SORL1 — implicated in late-onset Alzheimer's disease.   view more (2007-01-15)

NIAID scientists characterize the most infectious prion protein particles
A new study of prions-apparently malformed proteins that initiate deadly brain diseases such as Creutzfeldt-Jakob disease in humans-has yielded surprising information about how the size of prions relates to their infectivity.   view more (2005-09-08)

Coeliac disease may predict schizophrenia
A history of coeliac disease (gluten intolerance) is a risk factor for developing schizophrenia, finds a study in this week's BMJ. Previous studies have suggested an association between these two disorders. Researchers identified 7,997 people older than 15 who were admitted to any Danish... view more (2004-02-18)

Alzheimer's disease diagnosed 100 years ago today
One hundred years after the first diagnosis of Alzheimer's disease (AD) November 3, 1906, researchers at the Yerkes National Primate Research Center, Emory University, are focusing on neuroscience, immunology and vaccine research to better understand how AD develops and progresses as well as to... view more (2006-11-06)

Heart disease risk in British men is overestimated
Current scoring methods over-predict the risk of death from coronary heart disease in British men, according to a study in this week's BMJ.   view more (2003-11-26)

New compound may protect against liver cancer
Researchers have identified a new compound called CDDO-Im that protects against the development of liver cancer in laboratory animals.   view more (2006-02-15)

Cell death following blood 'reflow' injury tracked to natural toxin
Researchers at Johns Hopkins have discovered what they believe is the "smoking gun" responsible for most tissue and organ damage after a period of blood oxygen loss followed by a sudden restoration of blood oxygen flow.   view more (2006-11-30)
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