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Neurodegenerative Disease | Neurodegenerative Disease News, Research and Current Events
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PINK1 protects from Parkinson's
Parkinson disease (PD) is a common neurodegenerative disease characterized by the selective loss of midbrain dopaminergic neurons.   view more (2007-06-19)

Scientists show how thinking can harm brain cells
Scientists at the University of Rochester Medical Center have targeted a new culprit and method of attack on neurologic functions in diseases such as Alzheimer's and dementia associated with HIV.   view more (2005-11-04)

New insights into the diversity of Creutzfeldt-Jakob disease agents
Researchers from the United Kingdom and France have identified four separate biochemical subgroups in a selection of cases of Creutzfeldt-Jakob disease.   view more (2008-03-18)

A picture of progress: PET imaging and biomarkers explored at ACS meeting
Doctors often have wished they could dispense with diagnostic guesswork and simply peer inside a human body to see the effects of a disease or if a particular medicine really works.   view more (2005-09-01)

'Intrabody' can mop up mutant protein in Huntington's disease model
Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. Emory University researchers engineered a virus to make an intracellular antibody or "intrabody" against huntingtin, the protein whose mutant forms poison the... view more (2008-05-27)

'Sticky' mice lead to discovery of new cause of neurodegenerative disease
When a faulty protein wreaks havoc in cells and causes disease, researchers are usually quick to point the finger at a wayward gene. Now scientists are learning that some neurodegenerative diseases can develop even though a gene is perfectly normal.   view more (2006-08-14)

Protein aggregates in Lou Gehrig's disease linked to neuron death
French neurologist Jean-Martin Charcot first described amyotrophic lateral sclerosis (ALS) in 1869, but, nearly 140 years later, little is known about the cause of the devastating neurodegenerative disease, and there is no cure   view more (2005-10-27)

Variations in detoxifying genes linked to Lou Gehrig's disease
Genetic variations in three enzymes that detoxify insecticides and nerve gas agents as well as metabolize cholesterol-lowering statin drugs may be a risk factor for developing sporadic amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), and possibly responsible for a reported twofold... view more (2006-07-06)

Gas-blockers might slow down Alzheimer's disease
A noxious gas speeds up brain degeneration in Alzheimer's disease, according to a study in the November 7 issue of The Journal of Experimental Medicine.   view more (2005-10-31)

Scientists find how neural activity spurs blood flow in the brain
New research from Harvard University neuroscientists has pinpointed exactly how neural activity boosts blood flow to the brain. The finding has important implications for our understanding of common brain imaging techniques such as fMRI, which uses blood flow in the brain as a proxy for neural... view more (2008-06-26)

The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases
A phenomenon considered healthy for cells, such as the accumulation of long chains of glucose (glycogen), which tissues store for energy purposes, is harmful for neurons.   view more (2007-10-22)

Researchers discover a protein responsible for shaping the nervous system
A team of researchers led by The Hospital for Sick Children (SickKids), the University of Toronto (U of T) and Cold Spring Harbor Laboratory have discovered a protein that is responsible for shaping the nervous system.   view more (2005-12-08)

Seeing Alzheimer's amyloids
In an important step toward demystifying the role protein clumps play in the development of neurodegenerative disease, researchers have created a stunning three-dimensional picture of an Alzheimer's peptide aggregate using electron microscopy.   view more (2008-05-13)

A new pathway for halting neuronal death in Huntington's disease
The body is an extremely complex puzzle in which every piece plays a critical role. Should pieces disappear harmony is compromised. Such is the case with certain neurodegenerative diseases; when neurons suddenly die, the body's ability to function properly is jeopardized. CNRS (1) and INSERM... view more (2002-06-12)

Seven UK cases of Creutzfeldt-Jakob disease associated with transplanted human tissue
Seven cases of Creutzfeldt-Jakob disease (CJD) associated with transplanted human tissue have occurred in the UK over a period of 33 years, reveals a study published ahead of print in the Journal of Neurology Neurosurgery and Psychiatry.   view more (2006-04-20)

Limitations of Current Evaluation Techniques for the Cost-Effectiveness of Treatments for Parkinson's Disease
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Pharmaceutical and surgical therapies for PD are available and can alleviate the symptoms and complications. Unfortunately, despite these therapies, the disease relentlessly progresses. A new study in the journal Value... view more (2004-11-10)

Early detection of Alzheimer's disease a possibility
Research investigating concentrations of magnetite, a magnetic form of iron, in Alzheimer's disease tissue has produced preliminary results that suggest the possibility of developing a technique to detect Alzheimer's disease before clinical symptoms appear. The research*, published in Biology... view more (2003-04-07)

QBI neuroscientists make Alzheimer's disease advance
Queensland Brain Institute (QBI) neuroscientists at UQ have discovered a new way to reduce neuronal loss in the brain of a person with Alzheimer's disease.   view more (2008-06-10)

Higher folate levels linked to reduced risk for Alzheimer's disease
Individuals who take in higher levels of the nutrient folate through both diet and supplements may have a reduced risk of developing Alzheimer's disease.   view more (2007-01-09)

Penn study finds inhaled anesthetics accelerate the appearance of brain plaque in animals
Researchers at the University of Pennsylvania's School of Medicine have discovered that common inhaled anesthetics increase the number of amyloid plaques in the brains of animals, which might accelerate the onset of neurodegenerative diseases like Alzheimer's.   view more (2007-03-12)

Molecular basis for neurodegeneration in Ataxia telangiectasia
An upcoming paper from Dr. David Wassarman (University of Wisconsin School of Medicine and Public Health) in the May 1 issue of G&D lends new insight into the pathogenesis of neurodegeneration in Ataxia telangiectasia.   view more (2008-04-15)

Huntington's disease study shows animal models on target
An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntington's Disease (HD) closely resembles that of human HD patients.   view more (2007-08-01)

Could skin cells become brain cells? (p 172)
Results of an experimental study in this week's issue of THE LANCET highlight how adult skin cells can be made into precursor nerve cells, with potential implications for the future treatment of neurodegenerative disorders such as Parkinson's disease. Ethical and practical considerations limit the... view more (2004-07-07)

Blood urate levels associated with the progression of Parkinson's disease
Higher blood levels of the compound urate, a salt derived from uric acid that is associated with gout, may be associated with a slower progression of Parkinson's disease.   view more (2008-04-15)

Alzheimer`s Disease: Activity Generates New Nerve Cells For Old Mice
Activity Generates New Nerve Cells For Old Mice - Study Supports Link Between Active Life And Lower Risk Of Neurodegenerative Disease Active older people seem to have a lower risk of certain neurological disorders such as Alzheimer`s disease. A study published May 22 in the on-line edition of the... view more (2002-05-15)

A protein sequence associated with Huntington's disease may become life-saving vaccine component
On June 10, 2008 the scientific journal "Vaccine" published a paper by the Massachusetts based biotech company Cure Lab, Inc., demonstrating that a protein sequence important in neurodegenerative Huntington's disease can be safely used as a new generation of vaccine adjuvants.   view more (2008-06-11)

Protein's potential as a regulator of brain activity discovered
UC Irvine researchers have found that a protein best known for building connections between nerve cells and muscle also plays a role in controlling brain cell activity.   view more (2006-04-21)

Mad-cow culprit maintains stem cells
What do mad cow disease and stem cell research have in common? Whitehead Institute scientists have found that the same protein that causes neurodegenerative conditions such as bovine spongiform encephalopathy (mad cow disease) is also important for helping certain adult stem cells maintain... view more (2006-01-31)

Ground-breaking new insight into the development of Alzheimer's disease
According to estimates there are 85,000 Alzheimer patients in our country and approximately 20,000 new cases every year. This spectacular increase is due to the increasing ageing population. Unfortunately it is still unclear precisely which ageing process forms the basis of this spectacular rise in... view more (2008-04-23)

Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's
In preliminary results, researchers have shown that a drug which mimics the effects of the nerve-signaling chemical dopamine causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD).   view more (2006-07-05)

Study identifies potential drug target for Huntington's disease
An enzyme known to be critical for the repair of damaged cells and the maintenance of cellular energy may be a useful target for new strategies to treat Huntington's disease (HD) and other disorders characterized by low cellular energy levels.   view more (2006-07-31)

Memantine appears effective and safe in moderate to severe Alzheimer's disease
Memantine, a drug approved for the treatment of Alzheimer disease, appears safe and effective in patients with moderate to severe cases of the condition, according to a study in the January issue of Archives of Neurology.   view more (2006-01-10)

Enhanced environment restores memory in mice with neurodegeneration
Mice whose brains had lost a large number of neurons due to neurodegeneration regained long-term memories and the ability to learn after their surroundings were enriched with toys and other sensory stimuli.   view more (2007-04-30)

Downstate researchers target multiple sclerosis
Researchers at SUNY Downstate Medical Center have developed a substance that inhibits the progress of multiple sclerosis (MS) in an animal model. The agent, a novel calpain inhibitor, can be administered orally.   view more (2006-11-22)

New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease. "Our team has defined a second prion protein called 'Shadoo', that exists in addition to the well-known prion protein called 'PrP' " said Professor David Westaway, director of... view more (2007-08-17)

Poor sleep associated with cognitive decline in elderly women
Women who experienced cognitive decline over a 13 to 15 year period after age 65 were more likely to sleep poorly than women whose cognition did not decline.   view more (2007-07-17)

Newly discovered antibody may be body's natural defense against Alzheimer's
In an important advance in the battle against Alzheimer's disease, physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center have identified naturally occurring antibodies in human blood that may help to defend against this form of dementia as well as other... view more (2007-06-12)

Scripps research study reveals structural dynamics of single prion molecules
New techniques paint clearer picture of amyloid formation associated with protein-based inheritance and neurodegenerative diseases such as mad cow, Alzheimer's.   view more (2007-02-13)

Study in mice suggests molecules in plants have beneficial effect on Alzheimer's disease
A set of molecules found in certain plants appears to have a beneficial effect in brain tissue associated with Alzheimer's disease, according to a new study conducted in mice. The study was led by researchers at the University of South Florida and Cedars-Sinai Medical Center. An article in the... view more (2008-05-07)

New target for Alzheimer's disease identified
Alzheimer's disease (AD) is an incurable disease that is increasing in prevalence and will increase even more rapidly as the Baby Boom generation enters the age of highest risk. The available AD drugs are only partially effective in some patients. New strategies are urgently needed.   view more (2008-05-07)

Shape Matters: NC State Scientists Characterize Structure of Protein Involved in Preventing Alzheimer's, Huntington's Diseases
Scientists at North Carolina State University have effectively lifted the veil from an important protein that is linked to the prevention of neurodegenerative diseases like Alzheimer's and Huntington's.   view more (2006-07-26)

Mediterranean diet associated with reduced risk of Alzheimer's disease
Eating a Mediterranean diet, which emphasizes fruits, vegetables and olive oil and includes little red meat, is associated with a lower risk for Alzheimer's disease.   view more (2006-10-10)

Stem cells provide new tool for studying disease and identifying ALS drugs
Results of two studies funded by Project A.L.S. and appearing in today's advance online publication of Nature Neuroscience demonstrate that embryonic stem cells may provide a new tool for studying disease mechanisms and for identifying drugs to slow ALS, also known as Lou Gehrig's disease.   view more (2007-04-17)

Gold nanoparticles, radiation combo may slow Alzheimer's
Chemists in Chile and Spain have identified a new approach for the possible treatment of Alzheimer's disease that they say has the potential to destroy beta-amyloid fibrils and plaque - hypothesized to contribute to the mental decline of Alzheimer's patients.   view more (2006-01-05)

Role of anesthetics in Alzheimer's disease: Molecular details revealed
Inhaled anesthetics commonly used in surgery are more likely to cause the aggregation of Alzheimer's disease-related plaques in the brain than intravenous anesthetics.   view more (2007-01-29)

Overexcited neurons not good for cell health
Neurotransmitters have consequences. They initiate events that are critical to a healthy life, giving us the ability to move, to talk, to breathe, to think. But that's if the neurotransmitters are getting it right and sending proper signals downstream to muscle cells, neurons or other cells.   view more (2007-12-18)

Leaky blood vessels open up nerve cells to toxic assault in Lou Gehrig's disease
Leaky blood vessels that lose their ability to protect the spinal cord from toxins may play a role in the development of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, according to research published in the April issue of Nature Neuroscience.   view more (2008-04-08)

Untangling a pathology of Alzheimer's
Researchers have uncovered what appears to be a natural protective mechanism against a central cause of neuronal death in Alzheimer's and similar neurodegenerative diseases.   view more (2006-09-07)

Blood transfusion-transmitted infections: A global perspective
Thanks to the many blood-safety interventions introduced since 1984, the overall risk for most transfusion-transmitted infections has become exceedingly small.   view more (2006-09-28)

Researchers identify a gene responsible for cases of Lou Gehrig's disease
A team of Canadian and French researchers has identified a novel gene responsible for a significant fraction of ALS (sporadic amyotrophic lateral sclerosis) cases. ALS is commonly referred to as Lou Gehrig's disease, an incurable neuromuscular disorder that affects motor neurons and leads to... view more (2008-04-01)
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