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Neurotransmitter orexin associated with pleasure and reward pathways in the brain
Researchers at the University of Pennsylvania School of Medicine have discovered that the recently identified neurotransmitter orexin (also known as hypocretin) influences reward processing by activating neurons in the lateral hypothalamus region of the brain.   view more (2005-08-26)

Protein aggregates in Lou Gehrig's disease linked to neuron death
French neurologist Jean-Martin Charcot first described amyotrophic lateral sclerosis (ALS) in 1869, but, nearly 140 years later, little is known about the cause of the devastating neurodegenerative disease, and there is no cure   view more (2005-10-27)

Insomniac fish shed light on the molecular basis of sleep disorders
Sleep disorders are common and poorly understood. In humans, narcolepsy is a sleep disorder associated with sleepiness, abnormal dreaming, paralysis and insomnia.   view more (2007-10-16)

THE VALUE OF CYSTIC FIBROSIS SCREENING (p 789)
Research published in this week's issue of THE LANCET concludes that screening babies for cystic fibrosis provides the opportunity for more reliable prenatal diagnosis of the disease. The value of screening for the currently incurable disease cystic fibrosis has been the subject of debate over the... view more (2000-08-30)

Brain's cannabinoid system 'mellows' seizures
The same brain machinery that responds to the active substance in marijuana provides a central "on-demand" protection against seizures, researchers have found. They said their discoveries suggest that the "endocannabinoid" system might constitute a prime target for drugs against... view more (2006-08-17)

Bad cholesterol inhibits the breakdown of peripheral fat
he so called bad cholesterol (LDL) inhibits the breakdown of fat in cells of peripheral deposits, according to a study from the Swedish medical university Karolinska Institutet. The discovery reveals a novel function of LDL as a regulator of fat turnover besides its well-established detrimental... view more (2008-11-20)

Research suggests cause of neurodegeneration in Huntington's disease
The severe neurodegeneration associated with Huntington's disease may result from molecular mutations that block the transport of nutrients within cells.   view more (2006-05-31)

Epilepsy and brain pathology linked together by the protein ADK
The brain of individuals who suffer from epilepsy is characterized by astrogliosis, a brain pathology evidenced by a complex series of changes in the morphology and function of brain cells known as astrocytes.   view more (2008-01-03)

Insulin signaling and amphetamines
Abuse of psychostimulants such as amphetamine remains a serious public health concern. Amphetamines mediate their behavioral effects by stimulating dopaminergic signaling throughout reward circuits of the brain.   view more (2007-10-16)

Transcription factor protein's role in cell death, neurodegeneration and schizophrenia
Researchers at the University of Pennsylvania School of Medicine discovered that a protein called Elk-1 interacts with mitochondria, the energy storehouse of a cell, suggesting that this protein -— typically active in the nucleus — could play a role in cell death and... view more (2006-06-08)

Hebrew University, German And British Researchers Develop Means To Help Post-Traumatic Stress Sufferers
Try as we may to suppress memories of highly stressful experiences, they nevertheless come back to bother us - even causing attacks of intense fear or other undesirable behavioral impairments. Now a group of German, Israeli and British scientists and students have found that a gene-based approach... view more (2003-12-11)

Gladstone study links Alzheimer's with toxic protein fragments
New research from the Gladstone Institute of Neurological Disease details exactly how a mutant form of the protein apolipoprotein E, also known as apoE, is a causative factor for Alzheimer's disease.   view more (2005-12-15)

Molecular partners required for appropriate neuronal gene repression
In their efforts to understand the complex biology of life, scientists often seek to isolate individual elements of the puzzle for study, to break the problem down to a more manageable size. Single genes and molecules are closely analyzed to better understand their specific interactions with other... view more (2005-08-04)

Sugar helps control cell division
Johns Hopkins scientists have discovered that a deceptively simple sugar is in fact a critical regulator of cells' natural life cycle.   view more (2005-09-22)

Different forms of amyloid beta in Alzheimer's disease harm neurons in different ways
Researchers at UC Irvine have shown that different forms of amyloid beta lead to neural damage in different ways, leading to an increasingly complex view of amyloid toxicity in the Alzheimer brain.   view more (2006-06-01)

Clues to gene expression in cystic fibrosis will guide research
Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to... view more (2007-03-29)

Researchers create mouse lacking key inflammation gene
In a paper published yesterday in The Proceedings of the National Academy of Science (PNAS), researchers from Boston University School of Dental Medicine generated a mouse model exhibiting reduced inflammation.   view more (2006-09-07)

Estrogen curbs appetite in same way as the hormone leptin
Estrogen regulates the brain's energy metabolism in the same way as the hormone leptin, leading the way to a viable approach to tackling obesity in people resistant to leptin.   view more (2007-01-04)

Promising therapy for ALS delivers antisense drug directly to nervous system
Researchers from the University of California, San Diego (UCSD) School of Medicine, the Center for Neurologic Study and Isis Pharmaceutical Corporation have designed and tested a molecular therapy in animals that they hope will be a major development in the fight to treat amyotrophic lateral... view more (2006-07-27)

Flies on speed offer insight into the roles of dopamine in sleep and arousal
Methamphetamine, the drug of choice for long-distance truckers and college students pulling all-nighters, appears to do a similar trick for fruit flies, too. This finding is one of several in a new study that demonstrates a critical role for the neurotransmitter dopamine in the modulation of sleep,... view more (2005-07-12)

Long-term changes in experience cause neurons to sprout new long-lasting connections
Howard Hughes Medical Institute researchers have discovered that neurons in the brains of mice sprout robust new connections when the animals are adjusting to new experiences.   view more (2006-06-22)

Moderate alcohol consumption enhances the formation of new nerve cells - may contribute to alcohol dependency
Moderate alcohol consumption over a relatively long period of time can enhance the formation of new nerve cells in the adult brain. The new cells could prove important in the development of alcohol dependency and other long-term effects of alcohol on the brain. The findings are published by... view more (2005-04-26)

New insight into brain disorders
The function of an enzyme in the brain - strongly linked to a number of major brain diseases such as Alzheimer's, schizophrenia and bi-polar disorder - has been identified for the first time by researchers at the University of Bristol, UK.   view more (2007-03-01)

Study links Alzheimer's disease to abnormal cell division
A new study in mice suggests that Alzheimer's disease (AD) may be triggered when adult neurons try to divide. The finding helps researchers understand what goes wrong in the disease and may lead to new ways of treating it.   view more (2006-01-18)

The first 3 Teslas magnetic resonance imager for research
The University Hospital at the University of Navarra and the Applied Medicine Research Centre (CIMA) of the University has recently acquired a 3 Teslas magnetic resonance imager for joint use, the first for research applications in Spain.   view more (2006-10-27)
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