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Test reveals effectiveness of potential Huntington's disease drugs
A test using cultured cells provides an effective way to screen drugs against Huntington's disease and shows that two compounds-memantine and riluzole - are most effective at keeping cells alive under conditions that mimic the disorder, UT Southwestern Medical Center researchers report.   view more (2006-10-31)

Scientists Discover a Molecular Scaffold That Guides Connections Between Brain Cells
Brain cells known as neurons process information by joining into complex networks, transmitting signals to each other across junctions called synapses. But "neurons don't just connect to other neurons," emphasizes Z. Josh Huang, Ph.D., "in a lot of cases, they connect to very... view more (2008-05-21)

Master genetic switch found for chronic pain
In experiments with mice, researchers have found that eliminating what appears to be a master genetic switch for the development of pain-sensing neurons knocks out the animals' response to "neuropathic pain."   view more (2006-01-26)

HIV is a 'double hit' to the brain
New evidence reported in the August issue of Cell Stem Cell, a publication of Cell Press, offers a novel perspective on how the HIV/AIDS virus leads to learning and memory deficits, a condition known as HIV-associated dementia.   view more (2007-08-16)

Left-right wiring determined by neural communication in the embryonic worm
Most animals appear symmetrical at first glance, but we're full of internal lop-sidedness. From the hand used to pick up a pencil or throw a baseball, to where language is generated in the brain, to the orientation of our internal organs, humans are a glut of asymmetries.   view more (2007-05-18)

Pain in fibromyalgia is linked to changes in brain molecule
Researchers at the University of Michigan Health System have found a key linkage between pain and a specific brain molecule, a discovery that lends new insight into fibromyalgia, an often-baffling chronic pain condition.   view more (2008-03-11)

Cancer gene drives pivotal decision in early brain development
A gene linked to pediatric brain tumors is an essential driver of early brain development, researchers at Washington University School of Medicine in St. Louis have found.   view more (2007-11-14)

Commonly used antidepressants may also affect human immune system
Drugs that treat depression by manipulating the neurotransmitter serotonin in the brain may also affect the user's immune system in ways that are not yet understood, say scientists from Georgetown University Medical Center and a Canadian research institute.   view more (2006-01-20)

UCLA researchers discover how drug binds to neurons to stop drunken symptoms of alcohol
UCLA researchers discovered how an experimental drug, called Ro15-4513, binds to specific receptors on brain neurons, which helps explain how this drug stops the drunken behavioral symptoms of alcohol such as impaired motor coordination, memory loss and drowsiness.   view more (2006-05-09)

Scientists explore consciousness
An international team of scientists led by a University of Leicester researcher has carried out a scientific study into the realm of consciousness.   view more (2008-02-19)

Everything in its place: Researchers identify brain cells used to categorize images
Socks in the sock drawer, shirts in the shirt drawer, the time-honored lessons of helping organize one's clothes learned in youth. But what parts of the brain are used to encode such categories as socks, shirts or any other item, and how does such learning take place?   view more (2006-08-28)

A Novel Mechanism of Manganese-Induced Neurological Dysfunction Discovered
For decades, scientists have known that chronic exposure to high concentrations of the metal manganese can cause movement abnormalities resembling symptoms of Parkinson's disease, but apparently without the same neuron damage characteristic of Parkinson's patients.   view more (2006-08-29)

New insight into brain disorders
The function of an enzyme in the brain - strongly linked to a number of major brain diseases such as Alzheimer's, schizophrenia and bi-polar disorder - has been identified for the first time by researchers at the University of Bristol, UK.   view more (2007-03-01)

Sniffing out a better chemical sensor
Marrying a sensitive detector technology capable of distinguishing hundreds of different chemical compounds with a pattern-recognition module that mimics the way animals recognize odors, researchers at the National Institute of Standards and Technology (NIST) have created a new approach for... view more (2008-10-30)

Promising therapy for ALS delivers antisense drug directly to nervous system
Researchers from the University of California, San Diego (UCSD) School of Medicine, the Center for Neurologic Study and Isis Pharmaceutical Corporation have designed and tested a molecular therapy in animals that they hope will be a major development in the fight to treat amyotrophic lateral... view more (2006-07-27)

New compound reduces stroke damage
A group of German scientists has synthesized a new compound that dramatically decreases the damage to neurons in rats demonstrating stroke symptoms.   view more (2006-05-16)

Gladstone scientists prove neurons produce Alzheimer's-linked apolipoprotein E
A question long debated among Alzheimer's disease researchers has been definitively answered by scientists at the Gladstone Institute of Neurological Disease in San Francisco.   view more (2006-05-11)

Brain size may depend upon how neural cells are cleaved
Howard Hughes Medical Institute researchers have discovered a novel way in which the brain size of developing mammals may be regulated. They have identified a signaling pathway that controls the orientation in which dividing neural progenitor cells are cleaved during development.   view more (2005-07-15)

Decision-making — Demonstration of a link between cognition and execution
For the first time, a team of researchers in the Movement, Adaptation, Cognition Laboratory (CNRS/University Victor Ségalen, Bordeaux) has revealed the existence of an interaction at the cellular level between cognitive information and motor information.   view more (2007-02-09)

Sentry enzyme blocks two paths to Parkinson's disease
The degeneration of brain cells that occurs in Parkinson's disease may be caused by either externally provoked cell death or internally initiated suicide when the molecule that normally prevents these fatal alternatives is missing.   view more (2007-02-02)

St. Jude finds signaling system that halts the growth of a childhood brain cancer
A discovery by St. Jude Children's Research Hospital scientists suggests a safer way to treat medulloblastoma, a rare but often fatal childhood brain tumor. The group found that one of the brain's signaling pathways inhibits the growth of the highly aggressive cancer cells.   view more (2008-03-17)

A drug-sensitive 'traffic cop' tells potassium channels to get lost
Our brains are buzzing with electrical activity created by sodium and potassium ions moving in and out of neurons through specialized pores. To prevent the constant chatter from descending into chaos the activity of these ion channels has to be tightly regulated.   view more (2007-09-04)

Parkinson's approach with stem cells a promising first step
Brain cells derived from human embryonic stem cells improved the condition of rats with Parkinson's-like symptoms dramatically, but the treatment caused a significant problem - the appearance of brain tumors - that scientists are now working to solve.   view more (2006-12-04)

For The First Time, Patterns Of Excitation Waves Found In Brain's Visual Processing Center
Neuroscientists have long believed that vision is processed in the brain along circuits made up of neurons, similar to the way telephone signals are transferred through separate wires from one station to another.   view more (2007-08-01)

Language of a fly proves surprising
A group of researchers has developed a novel way to view the world through the eyes of a common fly and partially decode the insect's reactions to changes in the world around it. The research fundamentally alters earlier beliefs about how neural networks function and could provide the basis for... view more (2008-03-10)
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