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UVa Scientists Hot on Trail of Therapies for Deadly Lung Failure
Researchers at the University of Virginia Health System have identified a molecular target, or receptor, for potential drugs to treat acute respiratory distress syndrome (ARDS), a sudden and life-threatening failure of the lung.   view more (2006-02-22)

Specific antagonism lowers blood pressure
High blood pressure (hypertension) is associated with an increased risk of heart attack and stroke, and the frequent use of drugs known as NSAIDs, for example to treat individuals with rheumatoid arthritis, can cause hypertension.   view more (2007-08-17)

HIV accessory protein disables host immunity via receptor-protein intermediary
Researchers at the University of Pennsylvania School of Medicine discovered that an HIV-1 accessory protein called Vpr destroys the host cell's ability to survive by binding to a host receptor.   view more (2006-03-31)

Odd protein interaction guides development of olfactory system
Scientists have discovered a strange mechanism for the development of the fruit fly antennal lobe, an intricate structure that converts the chaotic stew of odors in the environment into discrete signals in the brain.    view more (2007-10-30)

Many receptor models used in drug design may not be useful after all
It may very well be that models used for the design of new drugs have to be regarded as impractical. This is the sobering though important conclusion of the work of two Leiden University scientists published in Science this week.   view more (2008-10-03)

Meth Promotes Spread of Virus in HIV-Infected Users
Researchers at the University at Buffalo have presented the first evidence that the addictive drug methamphetamine, or meth, also commonly known as "speed" or "crystal," increases production of a docking protein that promotes the spread of the HIV-1 virus in infected users.   view more (2006-08-07)

Researchers may have unlocked the mechanisms that silence the estrogen receptor gene alpha during breast cancer
The mechanisms that silence the estrogen receptor gene alpha (ER-α) in certain breast cancer cell lines may be closer to being unlocked.   view more (2007-08-20)

Biosensor sniffs out explosives
Temple University School of Medicine researchers have developed a new biosensor that sniffs out explosives and could one day be used to detect landmines and deadly agents, such as sarin gas, according to a paper in the June issue of Nature Chemical Biology.   view more (2007-05-09)

Cell-death receptor links cancer susceptibility and inflammation
For over 10 years, Wafik S. El-Deiry, MD, PhD, Professor of Medicine, Genetics, and Pharmacology at the University of Pennsylvania School of Medicine, has been pursuing a cancer-targeting molecule called TRAIL and its molecular partners.   view more (2007-12-28)

New Genetic Marker for Osteoarthritis - Study Links Estrogen Receptor to Osteoarthritis in Both Men and Women
Among patients with osteoarthritis (OA), a degenerative joint disease, postmenopausal women are the most prevalent. This fact has led to many hypotheses about the role of sex hormones in the cause and effects of OA. Medical researchers at Erasmus MC in the Netherlands recently uncovered a... view more (2003-06-26)

IL-21 receptor plays an essential role in the Th2 immune response
During the immune response cells known as Th2 cells express a variety of cytokines (e.g. interleukin-4, -5, and -13), many of which stimulate B cells to proliferate and produce antibodies.   view more (2006-06-16)

Study connects obesity with nervous system
A discovery by Queen's biologists and their students sheds new light on the genetic roots of obesity - a condition that is increasing dramatically in North America and has been linked to heart disease, diabetes and some forms of cancer.   view more (2008-01-24)

Variation in bitter-taste receptor gene increases risk for alcoholism
A team of researchers, led by investigators at Washington University School of Medicine in St. Louis, has found that a gene variant for a bitter-taste receptor on the tongue is associated with an increased risk for alcohol dependence.   view more (2006-01-10)

A new system for collaboration in cell communication
Investigators from the Institute of Research in Biomedicine (IRB Barcelona) have identified a new signalling mechanism among cells in the fruit fly, Drosophila melanogaster.   view more (2007-06-27)

Glutamate: Too much of a good thing in schizophrenia?
Is schizophrenia a disorder of glutamate hyperactivity or hypoactivity? While the predominant hypothesis for many years was that schizophrenia was a glutamate deficit disorder, there is growing evidence of glutamate hyperactivity as well.   view more (2008-10-28)

Active compounds found in Ganoderma lucidum fungus with potential to treat prostate cancer
A new development in the fight against cancer: Recent research at the University of Haifa found that molecules found in common fungus Ganoderma lucidum aid in suppressing some of the mechanisms involved in the progression of prostate cancer.   view more (2007-12-12)

UNC scientists discover 'gatekeeper' protein in blood clotting
New research from the University of North Carolina at Chapel Hill School of Medicine has identified a protein that may control blood clotting by keeping blood platelets from sticking together.   view more (2006-01-30)

Wasabi's kick linked to single pain receptor
A single pain receptor is responsible for the kick delivered by garlic and mustard oil, which is the active ingredient in mustard and in the pungent green sushi condiment known as wasabi, according to a Yale School of Medicine study published this week in Cell.   view more (2006-03-27)

Discovery of 'sugar sensor' in intestine could benefit diabetes
Diabetes patients could benefit from new research at the University of Liverpool that has identified a molecule in the intestine that can 'taste' the sugar content of the diet.   view more (2007-08-22)

Olfactory nerve cells expressing same receptor display a varied set of reactions
n a mouse model, University of Pennsylvania School of Medicine researchers discovered that olfactory sensory neurons expressing the same receptor responded to a specific odor with an array of speeds and sensitivities.   view more (2006-02-03)

Tarantula venom and chili peppers target same pain sensor
Venom from a West Indian tarantula has been shown to cause pain by exciting the same nerve cells in mice that sense high temperatures and the hot, spicy ingredient in chili peppers.   view more (2006-11-09)

Potential new targets for antidepressant medications
The news about antidepressant medications over the past several years has been mixed. The bad news from large multicenter studies such as STAR*D is that current antidepressant medications are effective, but not as effective as one might hope. Thus, there is a significant need for new treatment... view more (2008-08-27)

Marijuana-like compounds suppress the immune response
A group of Japanese scientists has discovered that cannabinoids can cause some white blood cells to lose their ability to migrate to the sites of infection and inflammation.   view more (2006-04-27)

Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
Genetically modifying a receptor found on the neurons that produce the neurotransmitter dopamine has given California Institute of Technology (Caltech) researchers a unique glimpse into the workings of the brain's dopamine system--as well as a new target for treating diseases that result from... view more (2008-10-15)

Food restriction increases dopamine receptor levels in obese rats
A brain-imaging study of genetically obese rats conducted at the U.S. Department of Energy's Brookhaven National Laboratory provides more evidence that dopamine - a brain chemical associated with reward, pleasure, movement, and motivation - plays a role in obesity.   view more (2007-10-25)
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