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Ashwell receptor reduces mortality during sepsis
In research that solves the longest-standing mystery in glycobiology - a field that studies complex sugar chains called glycans - researchers at the University of California, San Diego School of Medicine have discovered that a molecule in the liver of all animals, called the Ashwell receptor, is... view more (2008-05-19)

Study advances evidence for receptor's role in alcohol pleasure and problems
A genetic variant of a receptor in the brain's reward circuitry heightens the stimulating effects of early exposures to alcohol and increases alcohol consumption, according to a new study by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National... view more (2007-03-07)

Estrogen withdrawal results in bone loss, research shows that the Estrogen Receptor has a fundamental role
Professor Lance Lanyon, Principal of The Royal Veterinary College, Karla Lee, Helen Jessop, Rosemary Suswillo, Gul Zaman from the Department of Basic Sciences at The Royal Veterinary College have shown in their research that the Estrogen Receptor has a fundamental role in bone cells by adjusting... view more (2003-07-25)

A double-barreled immune cell approach for neuroblastoma
Adding an artificial tumor-specific receptor to immune system cells called T-lymphocytes that target a particular virus extended and improved the cells' ability to fight a form of childhood cancer called neuroblastoma, said researchers form Baylor College of Medicine and Texas Children's Hospital... view more (2008-11-03)

Endosome-mediated signaling in plants
In a paper that will be published online in advance of its July 1st publication date, Drs. Niko Geldner, Joanne Chory and colleagues (The Salk Institute and HHMI) demonstrate that endosomes can function as signaling platforms in plants, as well as in animals.   view more (2007-06-19)

New mechanism for cardiac arrhythmia discovered
It has long been thought that virus infections can cause cardiac arrhythmia. But why has not been understood. Ulrike Lisewski, Dr. Yu Shi, Michael Radke and Professor Michael Gotthardt of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now discovered the... view more (2008-09-18)

Discovering New Regulators Of The Immune System
London, U.K. and South San Francisco, CA, 15th September 2003. In an attempt to find new regulators of the immune system, a team of researchers at Rigel Pharmaceuticals, Inc. have created a successful method for discovering molecules that are involved in signalling pathways. As published this week... view more (2003-09-12)

Glycoprotein hormone receptors
We have aspired at understanding and further dissecting the molecular mechanism of activation of the Glycoprotein hormone receptors (GpHr), members of the G protein coupled receptor (GPCR) superfamily.   view more (2006-01-17)

Researchers explore the antidepressant effects of ketamine
Drug treatments for depression can take many weeks for the beneficial effects to emerge. The excruciating and disabling nature of depression highlights the urgency of developing treatments that act more rapidly.   view more (2008-02-22)

Turning on hormone tap could aid osteoporosis fight
A potential new drug that 'opens the taps' for the release of useful hormones could stimulate new bone growth - and may eventually bring relief to osteoporosis sufferers.   view more (2008-07-16)

Pregnancy and lactation may affect maternal behavior and coping skills
In the October 2006 issue of the journal Endocrinology, a collaborative research study by scientists at Cummings School of Veterinary Medicine at Tufts University and the University of Otago Medical School in Dunedin, New Zealand, shows that pregnancy and lactation in rodents produce long-term... view more (2006-09-21)

Structure of 450 million year old protein reveals evolution's steps
A detailed map that pinpoints the location of every atom in a 450-million-yeard-old resurrected protein reveals the precise evolutionary steps needed to create the molecule's modern version.   view more (2007-08-17)

Long-term estrogen therapy linked to breast cancer risk
Long-term estrogen therapy may be related to a higher risk of breast cancer among postmenopausal women who have had a hysterectomy, according to an article in the May 8 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.   view more (2006-05-09)

For the fruit fly, everything changes after sex
IMP Director Barry Dickson and his group are interested in the genetic basis of innate behaviour. They focus on the reproductive behaviour of the fruit fly Drosophila melanogaster. Two years ago, the team was able to identify the fruitless gene as a key regulator of mating behaviour.   view more (2007-12-11)

Cell research signals cancer hope
Scientists have moved a step closer to understanding what happens when cells receive a faulty signal that is known to be a cause of cancer.   view more (2005-02-03)

Genetic mutation alters response to heart failure drugs
The group of drugs known as beta blockers help slow nerve impulses traveling through the heart in order to reduce the heart's workload.   view more (2007-01-03)

Receptor could halt blinding diseases, stop tumor growth, preserve neurons after trauma
An international team of researchers has discovered what promises to be the on-off switch behind several major diseases.   view more (2008-10-07)

Stomach receptor for H. pylori discovered
Scientists have determined that decay-accelerating factor (DAF), a protein found in epithelial cells in the stomach, acts as a receptor for the bacteria Helicobacter pylori.   view more (2006-05-05)

Bacteria, beware: New finding about E coli could block infections, lead to better treatments
A newly discovered receptor in a strain of Escherichia coli can be blocked to avert infection, a finding that might aid in developing better therapies to treat bacterial infections resulting in food poisoning, diarrhea or plague.   view more (2006-06-27)

Looking beyond the drug receptor for clues to drug effectiveness
Antipsychotic drugs that are widely used to treat schizophrenia and other problems may not work as scientists have assumed, according to findings from Duke University Medical Center researchers that could lead to changes in how these drugs are developed and prescribed.   view more (2008-08-26)

Seeking better cancer treatments
EUREKA project E! 1948 SASTEREC and its follow-up E! 2705 SAMARDES carried out essential research with the human androgen receptor to understand the mechanism of the mode of action of androgens. The human androgen receptor (hAR) binds the male sex steroids and regulates genes for male... view more (2004-11-16)

Accessory protein determines whether pheromones are detected
Pheromones are like the molecules you taste as you chomp on a greasy french fry: big and fatty.   view more (2007-10-18)

Scientists find hormone activity explains adolescent mood swings
The "raging hormones" of puberty are known to produce mood swings and stress for most teenagers, making it difficult to cope with this period of life. Until now, the specific causes of pubertal anxiety have not been identified, making it harder to understand and treat adolescent angst.   view more (2007-03-12)

The role of fat as a signal substance
Fat is not only a much-discussed food substance. Fat can also function as a signal substance in the body and activate a special receptor in the cells of important organs like the heart and liver. This opens opportunities for new ways of explaining the genesis of diabetes, a disease that is strongly... view more (2003-02-10)

Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
Researchers at Johns Hopkins have discovered how to block a molecular switch that triggers brain damage caused by the lack of oxygen during a stroke.   view more (2005-12-21)
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