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Joslin study indicates insulin receptors play a critical role in promoting islet growth
A new Joslin-led study has identified the insulin receptor as an important protein that promotes islet cell growth in mice whose bodies are unable to use insulin properly, or are insulin resistant, a precursor to type 2 diabetes.   view more (2007-04-03)

Experiments could lead to new treatments for neuroblastoma
Neuroblastoma is one of the most devastating diagnoses a child can receive. The cancer's victims average 2 years old when the disease is detected, most often by a parent feeling a lump in a child's abdomen. By then, the disease has often reached an advanced stage, and advanced neuroblastoma kills... view more (2008-08-18)

Certain diseases, birth defects may be linked to failure of protein recycling system
A group of signaling proteins known as Wnt - which help build the human body's skin, bone, muscle and other tissues - depend on a complex delivery and recycling system to ensure their transport to tissue-building cell sites, according to a study at Cincinnati Children's Hospital Medical Center.   view more (2007-12-21)

Fruit fly protein acts as decoy to capture tumor growth factors, find Penn researchers
Researchers at the University of Pennsylvania School of Medicine have shown how Argos, a fruit fly protein, acts as a ¡¥decoy' receptor, binding growth factors that promote the progression of cancer.   view more (2008-05-29)

New cannabis-like drugs could block pain without affecting brain, says study
A new type of drug could alleviate pain in a similar way to cannabis without affecting the brain, according to a new study published in the journal Pain on Monday 15 September.   view more (2008-09-12)

Common bowel problem linked to chili pepper pain receptor
People with irritable bowel syndrome have a higher than usual number of chilli pepper pain receptors, according to a new study published tomorrow (Wednesday 11 June).   view more (2008-06-10)

Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
Carnegie Mellon University chemists have solved a decade-long molecular mystery that could eventually help scientists develop drug therapies to treat a variety of disorders, including epilepsy and Alzheimer's disease.   view more (2007-08-22)

Penn Scientists Show How Body Determines Optimal Amount of Germ-Fighting B Cells
Researchers at the University of Pennsylvania School of Medicine can now explain how the body determines whether there are enough mature B-cells in the blood stream at any one time. These are the cells that produce antibodies against germs to fight infections.   view more (2008-11-05)

Gene determines whether male body odor smells pleasant
To many, urine smells like urine and vanilla smells like vanilla. But androstenone, a derivative of testosterone that is a potent ingredient in male body odor, can smell like either - depending on your genes.   view more (2007-09-17)

Prenatal cocaine's lasting cellular effects
Although the "crack baby" hysteria of the 1980s was greatly exaggerated, cocaine use during pregnancy can cause subtle but disabling cognitive impairments — attention deficits, learning disabilities and emotional problems.   view more (2007-01-15)

MIT IDs link between brain tumor proteins
MIT researchers have identified a critical link between two proteins found in brain tumors, a discovery that could eventually help treat a form of brain cancer that kills 99 percent of patients.   view more (2007-07-20)

Why a common treatment for prostate cancer ultimately fails
Some of the drugs given to many men during their fight against prostate cancer can actually spur some cancer cells to grow, researchers have found. The findings were published online this week in a pair of papers in the Proceedings of the National Academy of Sciences.   view more (2008-08-22)

Ob1, the first commmon obesity gene was located on chromosome 10
Each family has at least one member whose body mass index (BMI, the ratio of the weight in kg to the surface of the body in m2; normal BMI is below 25) is higher than 40 and at least one other member whose BMI is over 27. 380 genetic markers, covering 23 pairs of chromosomes, were studied in order... view more (1998-11-16)

Life and death in the hippocampus: what young neurons need to survive
Whether newborn nerve cells in adult brains live or die depends on whether they can muscle their way into networks occupied by mature neurons.   view more (2006-08-14)

Science researchers genetically transform immune cells into tumor fighters
A team of researchers has genetically engineered normal immune cells to become specialized tumor fighters, demonstrating for the first time that these engineered cells can persist in the body and shrink large tumors in humans.   view more (2006-09-01)

Potential new approach to treat cognitive impairments in schizophrenia
A new study reports important evidence for a potential new treatment approach for those diagnosed with schizophrenia. Schizophrenia is considered one of the most devastating of the major psychiatric disorders, which has three distinct facets, often referred to as "positive"... view more (2007-09-25)

Iressa shows promise for treatment of metastatic breast cancer when combined with hormonal therapy
Gefitinib, the once-promising drug formerly approved as a second line treatment for lung cancer, also known as Iressa, enhanced the effectiveness of hormonal therapy for the treatment of specific types of metastatic breast cancer.   view more (2008-05-19)

Unexpected role: EGFR protects cancer cells from starving
A growth factor receptor found abundantly on the surface of cancer cells and long known to fuel cancer growth also protects tumor cells from starvation by a newly identified mechanism.   view more (2008-05-06)

Scientists discover major genetic cause of colorectal cancer
About one-third of colorectal cancers are inherited, but the genetic cause of most of these cancers is unknown. The genes linked to colorectal cancer account for less than 5 percent of all cases.   view more (2008-08-15)

Leptin has powerful effect on reward center in the brain
Leptin, a hormone critical for normal food intake and metabolism, exerts a strong effect on appetite by acting in the mid-brain region as well as in the hypothalamus.   view more (2006-09-29)

Novel compounds show promise as safer, more potent insecticides
Research teams at Nihon Nohyaku Co., Ltd., Bayer CropScience and DuPont have developed two new classes of broad-spectrum insecticides that show promise as a safer and more effective way to fight pest insects that damage food crops.   view more (2005-08-29)

Researchers Discover Method in Mice to Restore Tamoxifen Sensitivity in Resistant Breast Cancer
The widely used breast cancer drug tamoxifen (Nolvadex®), which can become less effective over time, might retain its full strength indefinitely if used along with a second drug, according to new research in mice conducted by investigators from the National Cancer Institute (NCI), part of the... view more (2006-12-21)

Gene expression test reveals ER and HER-2 status of breast tumors
Two critical characteristics of breast cancer that are important to treatment can be identified by measuring gene expression in the tumor, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in Lancet Oncology online.   view more (2007-02-15)

Study helps explain why botulinum toxin is so deadly
A pilot without a map can locate an airport by first finding a nearby landmark, like a big river, and then searching for the airport.   view more (2006-12-14)

Cell surface receptors are all 'talk' in T cell stimulation
Understanding the mechanisms that drive healthy immune responses is important when it comes to combating autoimmune diseases, which occur when cells that should attack invading organisms turn on the body instead.   view more (2008-06-13)
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