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Immune system discovery could aid fight against TB
A key aspect of how the body kicks the immune system into action against tuberculosis is revealed in research published today.   view more (2006-10-23)

DNA highly-promising predictor for successful treatment of alcoholics
According to Dutch researcher Wendy Ooteman, the biological and genetic characteristics of alcoholics can predict which drugs will best suppress the desire to drink.    view more (2006-10-05)

Unique estrogen receptor linked to metastatic breast cancer
Breast cancer awareness month may have passed, but researchers remain focused on the disease with a new study showing that a unique estrogen receptor found in breast cancer tumors is a predictor of tumor size and metastases.   view more (2006-11-01)

Alteration of brain protein regulates learning
Researchers at UT Southwestern Medical Center have identified a biochemical switch that affects how neurons fire in a part of the brain associated with learning, findings that may aid in understanding schizophrenia and Alzheimer's disease.   view more (2005-08-18)

Novel enzyme offers new look at male hormone regulation
For the second time in less than a year, University of North Carolina at Chapel Hill scientists have purified a novel protein and have shown it can alter gene activity by reversing a molecular modification previously thought permanent.   view more (2006-05-08)

New weapon in battle against osteoporosis
Medical researchers at the University of Bonn, working in collaboration with scientists from Israel, the USA and Britain, have identified a previously unknown regulatory mechanism in the process of bone loss. Their findings could open up new approaches to the treatment of osteoporosis.   view more (2006-01-03)

Researchers reveal how long-term use of anti-inflammatory medication can cause osteoporosis
The steroid hormones glucocorticoids (GCs) are used at high doses to treat inflammatory and immune disorders, however they prompt bone loss and can cause osteoporosis, particularly when administered for prolonged periods.   view more (2006-07-28)

Nicotine rush hinges on sugar in neurons
When nicotine binds to a neuron, how does the cell know to send the signal that announces a smoker's high"   view more (2007-07-23)

Zinc plays important role in brain circuitry
To the multitude of substances that regulate neuronal signaling in the brain and spinal cord add a new key player: zinc. By engineering a mouse with a mutation affecting a neuronal zinc target, researchers have demonstrated a central role for zinc in modulating signaling among the neurons.   view more (2006-11-27)

Molecular atlas provides new tool for understanding estrogen-fueled breast cancer
Lurking in unexplored regions of the human genome are thousands of previously unknown on/off switches that may influence how the growth of breast cancer is driven by estrogen.   view more (2006-10-03)

Biologists visualize protein interaction that may initiate viral infection
Biologists at Purdue University have taken a "snapshot" of a Velcro-like protein on a cell's surface just after it attached to the dengue virus, a linkup thought to initiate the early stages of infection.   view more (2006-02-10)

New target for obesity and related metabolic disorders
A new study reveals an attractive new target for therapies aimed at the treatment of obesity and related metabolic disorders, researchers report in the March Cell Metabolism.   view more (2006-03-08)

Scientists identify fundamental brain defect, probable drug target in fragile X syndrome
Scientists have discovered how the gene mutation responsible for fragile X syndrome--the most common inherited form of mental retardation--alters the way brain cells communicate.   view more (2007-09-18)

Genetic variant linked to odor perception
Why the same sweaty man smells pleasant to one person and repellant to another comes down to the smeller's genes.   view more (2007-09-17)

Research uncovers signaling pathways related to brain-immune system links
New research on signaling pathways in immune cells bolsters evidence of connections between the central nervous system and the immune system.   view more (2006-05-16)

The tachykinin receptor 3 gene has been linked to alcohol and cocaine dependence
The search for genes associated with alcohol dependence has recently been extended to the tachykinin receptor 3 gene, located within a broad region on chromosome 4q. Researchers have found that seven of the nine single nucleotide polymorphisms -- DNA sequence variations -- in the 3' region of TACR3... view more (2008-05-06)

Manipulating Cell Receptor Alters Animal Behavior
Researchers at the University at Buffalo and the University of Pennsylvania were the first to demonstrate that two intracellular events, both stimulated by the same cell receptor, can provoke different behaviors in mammals.   view more (2006-03-22)

Scientists Learn the Origin of Rogue B Cells
Doctors have long wondered why, in some people, the immune system turns against parts of the body it is designed to protect, leading to autoimmune disease.   view more (2007-02-08)

Study shows liver an excellent target for cancer gene therapy using viral vectors
A featured paper in the February 14 issue of Nature Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells.   view more (2007-02-15)

Unexpected features of anthrax toxin may lead to new types of therapies
Surprising new insights about the acid pH levels required for anthrax toxin to invade the cells of the body may help accelerate development of medications for the treatment of anthrax, a disease caused by a spore-forming bacterium.   view more (2005-08-30)

Cortisol and fatty liver: Researchers find cause of severe metabolic disorders
A healthy body stores fat in the form of so-called triglycerides in specialized fatty tissue as an energy reserve. Under certain conditions the delicate balance of the lipid metabolism gets out of control and fat is accumulated in the liver, leading to the dreaded fatty liver.   view more (2008-09-10)

Biomarker May Be an Early Predictor of Advanced Breast Cancer
Researchers have identified a molecule that may be more accurate than existing biological signposts used to predict which breast cancers will develop into advanced forms of the disease.   view more (2007-11-06)

Study uncovers significant functional differences of novel estrogen receptor
Because of these differences, this new estrogen receptor could become an important therapeutic target and may play a further signaling role in other estrogen target tissues, including uterus and prostate tissues.   view more (2006-06-09)

Study identifies source of fever
With the finding that fever is produced by the action of a hormone on a specific site in the brain, scientists have answered a key question as to how this adaptive function helps to protect the body during bacterial infection and other types of illness.   view more (2007-08-06)

LIAI scientists make important finding on cytomegalovirus transmission
Researchers at the La Jolla Institute for Allergy & Immunology have shown that cytomegalovirus (CMV) in the salivary glands can be reduced - and in some cases eliminated - through the use of antibodies to enhance the disease-fighting power of the immune system.   view more (2007-05-11)
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