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Researchers identify the cells and receptor for sensing sour taste
In the last seven years, Howard Hughes Medical Institute researcher Charles S. Zuker and Nicholas J.P. Ryba at the National Institutes of Health have worked together to identify the cells, receptors and signaling mechanisms for three of the five tastes humans can sense - sweet, bitter, and umami... view more (2006-08-24)

A new relationship between brain derived neurotrophic factor and inflammatory signaling
In the October 14th edition of Science Signaling researchers at Boston University School of Medicine (BUSM), The Children's Hospital of Philadelphia/University of Pennsylvania School of Medicine and The University of Colorado Denver School of Medicine have shown that the development of epilepsy in... view more (2008-10-23)

Grabbing addiction by the tail
Canadian scientists have developed some clever molecular trickery that is helping to reduce the drug cravings of addicted rats. One of the problems in addiction is that neurons in some parts of the brain lose glutamate receptors from the cell surface, and those receptors are important for... view more (2005-11-28)

Researchers create first model for retina receptors
A team of scientists at the University of Oklahoma Health Sciences Center has created the first genetic research model for a microscopic part of the eye that when missing causes blindness. The research appears in a recent issue of the Journal of Biological Chemistry.    view more (2008-10-01)

St. Jude study shows how T cell's machinery dials down autoimmunity
A St. Jude Children's Research Hospital study shows that T cells, the body's master immune regulators, do not use simple on/off switches to govern the cellular machinery that regulates their development and function. Rather, they possess sophisticated molecular controls that enable them to adjust... view more (2008-05-13)

Scripps Research scientists shed new light on how antibodies fight HIV
By furthering scientists' understanding of the molecular mechanisms that separate the minority of successful HIV antibodies from the majority of ineffective antibodies, the work may have implications for future attempts to design an HIV vaccine.   view more (2007-09-07)

Getting to the roots of hair loss
A healthy individual loses around a hundred hairs a day. Nothing to worry about as long as they are constantly replaced and the losses occur evenly around the whole scalp.   view more (2008-02-25)

Hormone helps mice 'hibernate,' survive starvation
A key hormone enables starving mice to alter their metabolism and "hibernate" to conserve energy, revealing a novel molecular target for drugs to treat human obesity and metabolic disorders, UT Southwestern Medical Center researchers have found.   view more (2007-06-06)

Targeted tumor therapy: When antagonists do the better job
Targeted tumor therapy lobs toxic payloads directly into tumors to destroy cancer cells while leaving normal cells unharmed.   view more (2006-10-23)

Halting retrieval of drug-associated memories may prevent addiction relapse
Disrupting the brain's retrieval of drug-associated memories may prevent relapse in drug addiction, according to new research in the August 13 issue of The Journal of Neuroscience.   view more (2008-08-13)

Reining in cancer - first laboratory study to show that combining novel targeted therapiesmay keep cancer cells under control
A team of Italian researchers has demonstrated in the laboratory for the first time that combining two of the newest anti-cancer targeted agents may produce a powerful new combination against breast cancer - and possibly many other cancers as well. Their findings are reported (Thursday 24 January)... view more (2002-01-21)

Aspirin and atherosclerosis
Aspirin has become one of the most widely used medications in the world, owing to its ability to reduce pain, fevers, inflammation, and blood clotting.   view more (2008-09-23)

Learning How SARS Spikes Its Quarry
Researchers have determined the first detailed molecular images of a piece of the spike-shaped protein that the SARS virus uses to grab host cells and initiate the first stages of infection.   view more (2005-09-16)

Linking 2 molecular pieces of the Alzheimer's puzzle
Researchers have uncovered a biological link between the protein whose mutation causes early-onset Alzheimer's disease (AD) and a gene variant linked to late-onset AD. The researchers said their finding could lead to new approaches to treating AD.   view more (2007-10-04)

A diagnosis of triple-negative breast cancer doesn't always mean cancer spread
Triple-negative breast cancers are a heterogeneous group and may not always be associated with lymph node spread, a new study shows.   view more (2008-04-14)

'VALUE' study results: more evidence that angiotensin-receptor blockers can reduce blood pressure among patients at high cardiovascular risk (pp 2010, 2022, 2049)
Results of a study in this week's issue of THE LANCET provide further evidence that a class of drugs that lower blood pressure are a treatment option for older people at high cardiovascular risk. The study also emphasises the importance of early blood-pressure lowering after the start of treatment... view more (2004-06-16)

New molecular regulators of hyperthyroidism and goiter
The thyroid gland has an important role in determining how much energy the body burns. Thyroid gland functions are regulated by a hormone known as thyroid-stimulating hormone (TSH).   view more (2007-08-10)

Researchers Reveal Possibility of Separating Anticancer Properties of Vitamin D
At the right dose, vitamin D is important for bone development and may help protect against the development of several cancers, particularly colorectal cancer.   view more (2006-03-20)

Biomarkers of response to VEGF pathway-targeted therapy discovered for renal cell carcinoma
Angiogenesis inhibitors can be far more effective in treating metastatic clear cell renal cell cancer (RCC)-an aggressive form of the most common kind of kidney cancer that is also rich in blood supply-than traditional treatments, according to accumulating evidence.   view more (2006-09-14)

Children's Hospital researchers identify molecular 'switch' that could save very young lives
A team of researchers at Children's Hospital of Pittsburgh of UPMC have identified a molecular "switch" that, when blocked, may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature infants.   view more (2007-12-05)

UCSD researchers identify critical receptor in liver regeneration
In studies in mouse models, researchers at the University of California, San Diego (UCSD) School of Medicine have found that a cellular receptor involved in triggering cell death is also a necessary component of tissue repair and regeneration immediately following liver injury.   view more (2007-03-30)

Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety
A small protein in the brain that has only recently been discovered and, paradoxically, induces both profound wakefulness and a less anxious state, may represent a novel target for the treatment of psychotic behavior and schizophrenia.   view more (2006-06-23)

Living taste cells produced outside the body
Researchers from the Monell Chemical Senses Center have succeeded in growing mature taste receptor cells outside the body and for the first time have been able to successfully keep the cells alive for a prolonged period of time.   view more (2006-02-27)

Scientists uncover the potential to control adult stem cells
Research being presented today (10 April) at the UK National Stem Cell Network Annual Science Meeting in Edinburgh represents a step towards the use of Adult Stem Cells (ASCs) to repair damaged tissue.   view more (2008-04-10)

UCLA scientists reveal how Nipah virus infects cells
UCLA scientists have discovered how the deadly Nipah virus infiltrates human cells to cause encephalitis. Designated as a potential bioterrorism agent by the National Biodefense Research Agenda, the virus exploits a protein essential to embryonic development to enter cells and launch its attack.   view more (2005-07-07)
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