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Off-label Prescribing Current Events | Off-label Prescribing News | 4

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New light microscope may help unlock some of cells' secrets
A microscopy technique pioneered with the help of Florida State University's National High Magnetic Field Laboratory has led to the development of a new light microscope capable of looking at proteins on a molecular level.   view more (2006-08-17)

Online game feeds music search engine project at UC San Diego
UC San Diego electrical engineers and computer scientists are working together on a computerized system that will make it easy for people who are not music experts (like the senior author's mom) to find the kind of music they want to listen to - without knowing the names of artists or songs.   view more (2007-09-26)

Mayo Clinic study tackles labeling errors
With a long-held commitment to continuously improving the quality and safety of patient care, Mayo Clinic researchers are recommending a new technologically-advanced labeling system aimed at reducing specimen labeling errors in a high-volume gastrointestinal endoscopy center   view more (2008-10-06)

Pramipexole delivered sustained efficacy in clinical trial of patients with Restless Legs Syndrome
Two large, randomised, placebo-controlled studies presented at the inaugural conference of the World Association of Sleep Medicine (WASM; Berlin, Germany) in October demonstrate that pramipexole delivered both short-term and sustained efficacy in patients suffering from Restless Legs Syndrome... view more (2005-12-12)

Study Suggests Tension Headache May Actually Be TMJD
People whose recurrent headaches have been diagnosed as tension-related actually may be suffering from temporomandibular muscle and joint disorder, or TMJD, a study headed by a researcher from the University at Buffalo's School of Dental Medicine has shown.   view more (2006-05-15)

Viagra passes initial safety test, but more research is needed
A study in this week’s BMJ finds no evidence for a higher incidence of fatal heart attack or ischaemic heart disease among English men taking sildenafil (Viagra). Although reassuring, further evidence is needed to confirm these findings, report the authors. Users of sildenafil were... view more (2001-03-13)

Action needed to avoid HIV drug resistance in Africa
We should stop and think about the risks of resistance, and ways of minimising them, before increasing access to antiretroviral therapy in Africa, argue researchers in this week's BMJ.   view more (2004-01-29)

What is the best treatment for postherpetic neuralgia?
A systematic review of the evidence for the many drug treatments used in post herpetic neuralgia (the pain that persists after shingles) concludes that long-established treatments such as tricyclic antidepressants and some opioids are as effective as newer drugs such as gabapentin, tramadol, and... view more (2005-07-26)

Study finds limitations in publicly reported quality-of-care indicators for heart-failure patients
Academic researchers reported that all five standard hospital-based performance measures used to gauge quality of care for hospitalized heart failure patients may not be the best benchmarks since none were significant predictors of patient mortality during the critical first 60 to 90 days... view more (2007-01-03)

Medical Whistleblowers Speak Out
FDA official says agency was "single greatest obstacle to doing anything effective" about Vioxx The US Food and Drug Administration (FDA) was "the single greatest obstacle to doing anything effective" about Vioxx, said FDA drug safety officer David Graham at an unprecedented... view more (2005-05-23)

Risks for painkiller abuse do not outweigh benefits in chronic pain
As controversy swirls about proper clinical use of opioids and other potent pain medications, research reported at the American Pain Society annual meeting shows that, contrary to widespread beliefs, less than 3 percent of patients with no history of drug abuse who are prescribed opioids for... view more (2008-05-09)

Launch of once-daily gliclazide offers ‘major step forward’ in type 2 diabetes management
OCDEM survey highlights need for improved compliance A new once-daily formulation of gliclazide, Diamicron 30mg MR, is launched in UK hospitals today (May 8th) by Servier Laboratories. The development has been described by a leading diabetologist as a ‘major step forward’ towards better... view more (2001-05-02)

Second-generation antipsychotic medications appear to offer little advantage over older drugs
Among patients with schizophrenia whose medication is changed because of ineffectiveness or harmful side effects, second-generation antipsychotic drugs do not appear to offer significant benefits compared to first-generation antipsychotic drugs.   view more (2006-10-03)

Drug labels are prescriptions for mistakes
A new study to assess understanding of five common prescription label instructions found that patients had difficulty comprehending how much and how often the medication should be taken.   view more (2006-11-30)

Inhaler devices for the management of asthma and COPD
The latest issue of Effective Health Care focuses on the effectiveness of inhaler devices used to manage asthma and chronic obstructive pulmonary disease (COPD). Inhaled therapy delivering bronchodilator and corticosteroid drugs in various doses is the mainstay of treatment for patients with asthma... view more (2003-01-14)

South Asian patients are missing out on cholesterol drugs
Patients in general practices with a greater South Asian population are less likely to be prescribed cholesterol lowering drugs, despite being at a higher risk of coronary heart disease than white patients, finds a study in this week`s BMJ.   view more (2002-07-03)

Post-marketing studies finding adverse events in drugs used in children
The Food and Drug Administration Modernization Act (FDAMA, 1997), designed to stimulate more drug safety studies in children, has resulted in more than 130 label changes since its inception nearly six years ago, according to researchers at Duke Children's Hospital.   view more (2008-09-02)

Pharmacists can conduct effective consultations with patients
Consultations with a trained pharmacist are an effective way of reviewing the drug treatment of older patients, without affecting the workload of general practitioners, concludes a study in this week's BMJ.   view more (2001-12-05)

Telecoms: Important step to better network performance
Heidelberg/Rockville/Adastral Park. Today, Eurescom, Spirent Communications, and BTexact Technologies announced the completion of a test that confirms the feasibility of performance management for IP Quality of Service (QoS) using Multiprotocol Label Switching (MPLS). As a result of this test,... view more (2002-10-15)

New anti-psychotic drugs no better than older, cheaper ones
A study led by The University of Manchester's Division of Psychiatry has found that schizophrenia patients respond just as well-and perhaps even better-to older psychiatric drugs as newer, costlier alternatives.   view more (2006-12-05)

Researchers provide dose of education to lower blood pressure
The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has launched a $3.7 million, three-year educational effort to improve high blood pressure control nationwide.   view more (2006-02-03)

Does alcohol labelling encourage sensible drinking?
Clear labelling on shop-bought alcohol, showing the alcohol units contained and health advice, may not be effective in promoting sensible drinking, says a letter in this week's BMJ.   view more (2006-02-06)

Nice but naughty -- our addiction to chocolate
Chocolate is the most widely and frequently craved food. People readily admit to being 'addicted to chocolate' or willingly label themselves as 'chocoholics'. A popular explanation for this is that chocolate contains mood-enhancing (psychoactive) ingredients that give it special appeal.   view more (2007-09-11)

New antibiotic prescribing policies needed to curb resistance BMJ Volume 324, pp 28-30
Effect of B lactam antibiotic use in children on pneumococcal resistance to penicillin: prospective cohort study The likelihood of children carrying a resistant bug is related to the amount of antibiotics they take, finds a study in this week's BMJ. If these drugs are to retain their clinical... view more (2002-01-02)

Special education data provide misleading trends of changing autism prevalence
If statistics compiled by the U.S. Department of Education are to be believed, in 1992 the state of Illinois had only 322 diagnosed cases of autism among school children. In 2003, according to the same statistical source, Illinois had more than 6,000 children diagnosed as autistic.   view more (2006-04-03)

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