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Scientists find the pathological prion protein in skeletal muscles of hamster with scrapie
In the May 2003 issue of EMBO reports, researchers from the German Robert Koch Institute in Berlin report finding the pathological prion protein PrPSc in a wide range of skeletal muscles after feeding hamsters with prion-infected food. PrPSc is believed to be an essential - if not the sole -... view more (2003-04-10)

Compulsive gamblers always down on their luck
Gambling addicts don't learn from their mistakes, according to a study published today in the open access journal Clinical Practice and Epidemiology in Mental Health. The problem could be explained by a kind of mental rigidity that leads to harmful compulsive behaviour in sufferers.   view more (2008-03-27)

Gastric cancer with 3 pathological features
Primary carcinoma of the stomach is almost always adenocarcinoma or signet ring cell carcinoma and there are few reports of choriocarcinoma or neuroendocrine cell carcinoma.   view more (2008-09-18)

Anti-wrinkle compound causes pathological reaction in skin cells
Researchers from Université Laval's Faculty of Medicine have discovered that a compound commonly used in many antiwrinkle products causes a pathological reaction in skin cells.   view more (2007-04-12)

Hold your horses
For those who suffer with the debilitating symptoms of Parkinson's disease, Deep Brain Stimulation offers relief from the tremors and rigidity that can't be controlled by medicine.   view more (2007-10-26)

U of M study: Health food supplement may curb addiction of pathological gamblers
University of Minnesota researchers have discovered that a common amino acid, available as a health food supplement, may help curb pathological gamblers' addiction.   view more (2007-09-12)

A case of false positive octreoscan in Crohn's disease
Neuroendocrine tumors, such as carcinoid tumors, overexpress somatostatin receptors in their membranes. Octreotide is an analogue whose molecule is a shortened version of somatostatin's with a high affinity for these receptors.   view more (2008-09-22)

Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons
Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with amyotropic lateral sclerosis (ALS), or Lou Gehrig's disease.   view more (2008-06-17)

New Editor-in-Chief for the Journal of Pathology
John Wiley is pleased to announce that Professor Simon Herrington has been appointed the new Editor-in-Chief for the Journal of Pathology.   view more (2002-02-13)

Mimicking a human disease in mice: a new model for the Parkinson related illness multiple system atrophy
In this month`s issue of EMBO Reports Kahle et al. describe how they genetically engineered a mouse to show pathological symptoms similar to those of human patients suffering from the neural disease Multiple System Atrophy (MSA), also known as Shy-Drager-Syndrome. The model could help researchers... view more (2002-06-06)

Drug commonly used for alcoholism curbs urges of pathological gamblers
A drug commonly used to treat alcohol addiction has a similar effect on pathological gamblers - it curbs the urge to gamble and participate in gambling-related behavior, according to a new research at the University of Minnesota.   view more (2008-06-16)

The UAB heads a European research project on proteases and pathological processes
A research group of the UAB Institute of Biotechnology and Biomedicine and the UAB Department of Biochemistry and Molecular Biology, directed by Francesc Xavier Avilés, is the coordinator of a European project aimed at studying proteases with fluorescent molecules that allow their monitoring... view more (2007-07-18)

Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer
The number of lymph nodes that contain evidence of cancer is the best predictor of the effectiveness of adding chemotherapy and radiation to a treatment plan prior to surgery in individuals with oesophageal cancer.   view more (2007-07-16)

Medical therapy for restless legs syndrome may trigger compulsive gambling
Compulsive gambling with extreme losses — in two cases, greater than $100,000 — by people without a prior history of gambling problems has been linked to a class of drugs commonly used to treat the neurological disorder restless legs syndrome (RLS).   view more (2007-02-09)

Research uncovers new steps on pathway to enlarged heart
Researchers have new insight into the mechanisms that underlie a pathological increase in the size of the heart. The research, published by Cell Press in the October 24th issue of the journal Molecular Cell, may lead to the development of new strategies for managing this extremely common cardiac... view more (2008-10-24)

Night blindness may explain fear of the dark
Fear of the dark is a common complaint in children and is often attributed to attention seeking behaviour. Yet researchers in this week's BMJ suggest that it may be due to night blindness - a diagnosis which can be easily missed. They describe two children with an inherited form of stationary night... view more (2003-01-22)

How brain pacemakers erase diseased messages
Brain "pacemakers" that have helped ease symptoms in people with Parkinson's disease and other movement disorders seem to work by drowning out the electrical signals of their diseased brains.   view more (2007-05-31)

First evidence of brain abnormalities found in pathological liars
A University of Southern California study has found the first proof of structural brain abnormalities in people who habitually lie, cheat and manipulate others.   view more (2005-09-30)

People Use Separate Brain Mechanisms to Make Ambiguous and Risky Choices
Distinct regions of the human brain are activated when people are faced with ambiguous choices versus choices involving only risk, Duke University Medical Center researchers have discovered.   view more (2006-03-06)

More genes for Lou Gehrig's disease identified, according to Penn researchers
In recent months a spate of mutations have been found in a disease protein called TDP-43 that is implicated in two neurodegenerative disorders: amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, and certain types of frontotemporal dementia (FTD). These mutations could... view more (2008-04-08)

New Study Shows that Fetal Cells Transplanted into the Brain to Treat Parkinson's Disease May Not Function Long Term
Neurons grafted into the brain of a patient with Parkinson's disease fourteen years ago have developed Lewy body pathology, the defining pathology for the disease, according to research by Jeffrey H. Kordower, PhD, and associates and published in the April 6 issue of Nature Medicine.   view more (2008-04-07)

Protein controls blood vessel formation, offers new drug target
After an injury, the body grows new blood vessels to repair damaged tissue. But sometimes too much growth causes problems, as when new blood vessels in the eyes leak, causing diabetic retinopathy and blindness if not treated.   view more (2007-12-05)

Reduced mitochondrial function important mechanism in aging
Scientists at the Karolinska Institute have found that changes in the "powerhouse" of cells, the mitochondria, play a key role in aging. The findings are being published in this week's issue of the journal Nature. Mitochondria, which provide energy to cells, have their own set of DNA.... view more (2004-05-27)

A rare case of ischemic colitis caused by chronic venous insufficiency
Ischemic injury to the bowel is a well known disease entity that has a wide spectrum of pathological and clinical findings. A sudden drop in the colonic blood supply is key to its development.   view more (2008-05-21)

Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis
While there have been significant advances in the use of gene expression profiling to assess a cancer prognosis, a Mayo Clinic review and analysis of existing lung cancer studies shows that this technology has not yet surpassed the accuracy of conventional methods used to assess survival in lung... view more (2006-11-17)
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