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Modified collagen could yield important medical applications
Collagen often pops up in beauty products and supermodel lips. But by mating collagen with a molecular hitchhiker, materials scientists at Johns Hopkins hope to create some important medical advances. view more (2005-08-31)
Blood pressure enzyme can have tumor-sensing role
By increasing production of a blood pressure-regulating enzyme in mice, researchers have found they can enhance the mouse immune system's ability to sense tumor growth. view more (2008-04-08)
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities. view more (2009-11-12)
Alzheimer's: New findings resolve long dispute about how the disease might kill brain cells
For a decade, Alzheimer's disease researchers have been entrenched in debate about one of the mechanisms believed to be responsible for brain cell death and memory loss in the illness. view more (2009-04-16)
Scripps research team identifies key molecules that inhibit viral production
The research, led by Professor Donny Strosberg of Scripps Florida, was published on March 4, 2009, in the Journal of General Virology's advance, online edition, Papers in Press. In the new study, Strosberg and his colleagues describe peptides (molecules of two or more amino acids) derived from the core protein of hepatitis C. The team found that... view more... (2009-03-11)
Reexamination of T. rex verifies disputed biochemical remains
A new analysis of the remains of a Tyrannosaurus rex (T. rex) that roamed Earth 68 million years ago has confirmed traces of protein from blood and bone, tendons, or cartilage. view more (2009-07-29)
An atomic-level look at an HIV accomplice
Since the discovery in 2007 that a component of human semen called SEVI boosts infectivity of the virus that causes AIDS, researchers have been trying to learn more about SEVI and how it works, in hopes of thwarting its infection-promoting activity. view more (2009-11-20)
Potential Alzheimer's disease drug target identified by UC San Diego researcher
In findings with the potential to provide a therapy for Alzheimer's disease patients where none now exist, a researcher at the University of California, San Diego and colleagues have demonstrated in mice a way to reduce the overproduction of a peptide associated with the disease. view more (2008-03-17)
Exhaustion of HIV-specific T cells may be caused by chronic exposure to virus
The "exhaustion" of immune cells that target HIV appears to result from chronic exposure to the virus, specifically exposure to the particular protein segments targeted by the pathogen-killing HIV-specific CD8 T cells. view more (2008-05-06)
Transporter is possible target for safer pain medicine
A transporter that silences one of the body's natural pain killers holds promise for new powerful, non-addictive pain medicines as well as understanding AIDS patients' increased pain perception. view more (2006-06-12)
Modeling pathogen responses
The search for a vaccination against HIV has been in progress since 1984, with very little success. Traditional methods used for identifying potential cellular targets can be very costly and time-consuming. view more (2007-10-12)
Novel approach for rapid identification and development of malaria vaccines
Malaria is the world's most frequent parasitic disease, affecting more than 100 countries in the tropical zones, mostly in Africa, and 40% of the world population, with more than a million deaths per year. view more (2007-07-25)
Caltech chemists say antibody surrogates are just a 'click' away
Chemists at the California Institute of Technology (Caltech) and the Scripps Research Institute have developed an innovative technique to create cheap but highly stable chemicals that have the potential to take the place of the antibodies used in many standard medical diagnostic tests. view more (2009-07-10)
UC San Diego researchers eliminate drug discovery bottleneck
Determining the structure of unknown natural compounds is a slow and expensive part of drug screening and development - but this may now change thanks to a new combination of experimental and computational protocols developed at the University of California, San Diego and presented at RECOMB 2008 (Research in Computational Molecular Biology) on... view more... (2008-03-31)
What can we do for prevention and therapy of anaerobe-associated infections?
Anaerobic microorganisms are important constituents of both human and animal intestinal microbiota. Infections caused by anaerobic bacteria are increasingly being recognized as major problem in clinical medicine. view more (2008-09-26)
University of Iowa scientists use blood-brain barrier as therapy delivery system
The blood brain barrier is generally considered an obstacle to delivering therapies from the bloodstream to the brain. However, University of Iowa researchers have discovered a way to turn the blood vessels surrounding brain cells into a production and delivery system for getting therapeutic molecules directly into brain cells. view more (2009-09-22)
A New Category of Antibiotics May Present a Fresh Threat to Public Health
Bacteria have developed resistance to all antibiotics in use today, and this is causing a major health problem. However, a remarkable range of new antibiotics, called cationic antimicrobial peptides (AMPs), is attracting increasing interest as a key weapon in the fight against bacterial infection. They are based on toxic proteins that are part of... view more... (2003-06-13)
Alcoholism research reveals promising new approach to treating Alzheimer's disease
Saint Louis University research shows a new class of drugs may hold promise in treating brain chemical problems such as Alzheimer's disease, says the principal investigator of research published in an early on-line version of Peptides. view more (2005-10-26)
Scientists design potent anthrax toxin inhibitor
Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have engineered a powerful inhibitor of anthrax toxin that worked well in small-scale animal tests. view more (2006-04-25)
Food or its expectation sparks brain's hunger centers
The concept of whetting the appetite by serving hors d'oeuvres before a meal may have a solid scientific basis. view more (2006-10-04)
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