Phenotypic Variation Current Events | Phenotypic Variation News
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First results of the Narval trial (ANRS 088)
Patients with HIV infection may develop resistance to one or more of antiretroviral drugs to which they are exposed during treatment. The selection of the most appropriate drugs for switching therapy in patients who have developed resistance, is a difficult challenge. Both, genetic tests that identify mutations in viral genes associated with... view more... (2000-04-21)
Chimpanzee study reveals genome variation hotspots
Researchers believe that dynamic regions of the human genome - "hotspots" in terms of duplications and deletions - are potentially involved in the rapid evolution of morphological and behavioral characteristics that are genetically determined. view more (2006-05-16)
Gene-expression profiling of the effects of liver toxins
Gene-expression data from liver tissue or whole blood can be used to classify histopathologic differences in the effects of hepatotoxins. It is hoped that these findings, published in BioMed Central's open access journal, Genome Biology, will lead to a more precise way of defining the potential hepatotoxicity of new compounds. view more (2008-06-20)
Researchers announce results of study on genetic variation in Parkinson's disease
Researchers at the National Institutes of Health (NIH) have completed one of the first large-scale studies of the role of common genetic variation in Parkinson's disease (PD). view more (2006-09-28)
Ecosystem consequences of a single, genetically based plant trait
Climate is often touted as the most important regulator of decomposition and nutrient cycling processes in forest ecosystems, however, in the forthcoming issue of Ecology Letters, Schweitzer and her research team from Northern Arizona University and the University of Wisconsin, USA, demonstrate that plant genes can have strong effects on the... view more... (2004-02-05)
Vaccine to cope with viral diversity in HIV
The ability of HIV-1 to develop high levels of genetic diversity and acquire mutations to escape immune pressures contributes to our difficulties in producing a vaccine. view more (2007-04-27)
Outwitting pesky parasites
Across the southern United States, an invisible, yet deadly parasite known as the root-knot nematode is crippling soybean crops. view more (2007-07-16)
Genomics throws species definition in question for microbes
Until a decade ago, scientists categorized microorganisms almost exclusively by their physical characteristics: how they looked, what they ate, and the by-products they produced. view more (2007-03-27)
New discovery: Molecular variation in one gene affects the growth of natural populations
For the first time, ecologists have been able to show that molecular variation in one gene may affect the growth of a population in its natural habitat. view more (2006-04-26)
Challenges of HIV-1 subtype diversity
A review article in the New England Journal of Medicine explores the genetic variation of HIV-1 and its implications for preventing and treating the disease. Francine McCutchan, Ph.D., a researcher with the U.S. Military HIV Research Program, co-authored the article, which appeared in the April 10, 2008 edition. view more (2008-05-22)
Age is more than a number — In barn owls, it reveals how susceptible one is to climate change
Fluctuations in weather and the environment affect survival and reproduction of animals. But are all individuals within a population equally susceptible? Theory on the evolution in age-structured populations suggests not - those life stages that are more important for overall fitness should be less susceptible to environmental variation than other... view more... (2007-01-11)
APPLYING SHEWHART'S CONTROL CHARTS TO CLINICAL GOVERNANCE (p 463)
A theory of variation used for quality control in the manufacturing industry since the 1920s could have helped in the earlier detection of recent UK health crises, suggest authors of an article in this week's issue of THE LANCET. The physicist and engineer Walter Shewhart devised a simple graphical method based on mathematical theory and practical... view more... (2001-02-07)
A new kind of mutation could explain numerous phenotypic variations in various species
The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form. view more (2006-06-06)
Eutrophication affects diversity of algae
Eutrophication of the seas may have an impact on genetic variation in algae, research at the University of Gothenburg shows. view more (2009-10-20)
New technology used to construct the first map of structural variation in the human genome
Beyond the simple stream of one-letter characters in the human genome sequence lies a complex, higher-order code. In order to decipher this level of architecture, scientists have developed powerful new experimental and algorithmic methods to detect copy number variants (CNVs)-defined as large deletions and duplications of DNA segments. view more (2006-11-27)
Variation in the same gene affects rate of parasite infection in both humans and baboons
Researchers at the Duke University Institute for Genome Sciences & Policy have found that variation in the same gene in humans and baboons produces the same kind of disease resistance. view more (2009-06-25)
Rhythmic genomics -- the yeast metronome and the walk of life
New genome sequence information from the humble baker's yeast has revealed surprising variation in a set of genes that can be thought of as nature's oldest clock. view more (2009-04-08)
Deprived areas show greatest increase in teenage pregnancies
From the 1980s to the 1990s rates of teenage pregnancy in Scotland increased more rapidly in areas of greater socioeconomic deprivation, finds a study in this week's BMJ. This finding has implications for allocating resources to achieve government targets in reducing pregnancy rates by 2010. Research carried out at Glasgow University investigated... view more... (2001-07-25)
Tiny genetic differences have huge consequences: McGill researchers
A study led by McGill University researchers has demonstrated that small differences between individuals at the DNA level can lead to dramatic differences in the way genes produce proteins. view more (2008-01-21)
UI Study Reveals Value of Schizophrenia-Related Gene Variation
University of Iowa researchers have learned more about a genetic variation that is a small risk factor for a mild form of schizophrenia, yet also is associated with improved overall survival. view more (2007-02-14)
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