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A balancing act in Parkinson's disease: Phosphorylation of alpha-synuclein
Both genetic and pathologic data indicate a role for the neuronal protein alpha-synuclein in Parkinson disease. view more (2009-10-13)
New method for detection of phosphoproteins reveals regulator of melanoma invasion
Scientists have developed a new approach for surveying phosphorylation, a process that is regulated by critical cell signaling pathways and regulates several key cellular signaling events. view more (2009-04-10)
One Signal Elicits Thousands of Answers
Cell signaling mechanisms often transmit information via protein modifications, most importantly the reversible attachment of phosphate, the so-called protein phosphorylation. view more (2006-11-13)
Hot Paper in the Biochemical Journal
DNA DAMAGE INSIGHT An exciting new paper from the Biochemical Journal regarding the phosphorylation state of LKB1 in response to ionising radiation can be viewed online as an Immediate Publication at www.BiochemJ.org (DOI: 10.1042/BJ20021284). Researchers at the University of Dundee, the University of Calgary and Tel Aviv University collaborated... view more... (2002-09-20)
Neutrophils in rheumatoid arthritis: How to lessen inflammation but still fight infection
Neutrophils, which quickly congregate at the sites of infection and inflammation, are capable of ingesting microorganisms or other particles. view more (2006-06-16)
Anesthesia is found to induce hyperphosphorylation of tau at sites related to Alzheimer's disease
Scientists from The New York State Office of Mental Retardation and Developmental Disabilities' (OMRDD) New York State Institute for Basic Research in Developmental Disabilities (IBR) report today in the March 2009 issue of the Journal of Alzheimer's Disease that anesthesia induces phosphorylation of tau. view more (2009-03-10)
What makes stem cells tick?
Investigators at the Burnham Institute for Medical Research (Burnham) and The Scripps Research Institute (TSRI) have made the first comparative, large-scale phosphoproteomic analysis of human embryonic stem cells (hESCs) and their differentiated derivatives. view more (2009-08-07)
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site
Synopsis: Two papers from Woods and colleagues describe novel roles for members of the dual specificity tyrosine phosphorylated and regulated kinase (DYRK) family. In one, DYRK1A is shown to phosphorylate a novel site in the transcription factor FKHR (a forkhead protein) regulating its nuclear presence and transcriptional activity. In the second... view more... (2001-04-24)
Researchers identify 1 of the necessary processes in the formation of long-term memory
A new study that was carried out at the University of Haifa has identified another component in the chain of actions that take place in the neurons in the process of forming memories. view more (2009-09-08)
All eukaryotic kinases share 1 common set of substrates
Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death. view more (2007-08-22)
Biological Timekeeper Studies Reveal New Temperature Regulator and Track Clock Protein across a Day
Dartmouth Medical School geneticists have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes the ebb and flow of daily activities. view more (2009-05-18)
Lifestyle can alter gene activity, lead to insulin resistance
A Finnish study of identical twins has found that physical inactivity and acquired obesity can impair expression of the genes which help the cells produce energy. view more (2008-06-19)
Insights into activity-dependent neuronal growth through RSRF-supported research
Brain-derived neurotrophic factor (BDNF) has been a subject of keen interest in neuroscientific circles for several years, turning up in studies of conditions ranging from central hypoventilation syndrome to obsessive-compulsive disorder, depression, bipolar disorder and schizophrenia - a range of disorders uncannily parallel to those produced by... view more... (2006-10-23)
Protein can help cells or cause cancer, Purdue researcher finds
A Purdue University scientist has discovered a key process in cell growth that can lead to the formation of tumors. view more (2009-07-08)
Early to bed, early to rise
In an upcoming G&D paper, a team of German scientists presents a genetic basis for understanding human morning lark behavior. Dr. Achim Kramer (Charité Universitaetsmedizin Berlin) and colleagues have uncovered a genetic cause for the human familial advanced sleep phase syndrome (FASPS), which causes people to both go to sleep and wake up... view more... (2006-09-20)
Protein linked to growth of organs and cancer
Johns Hopkins scientists have identified a protein in fruit flies whose counterpart product in humans may help cause cancer. view more (2005-08-12)
Aspirin discovery may improve cancer treatments
Salicylates, including aspirin, are used to treat a range of inflammatory conditions and can be used to prevent diseases such as cancer, but the way aspirin works is not yet fully understood. view more (2007-04-06)
Cancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered. view more (2009-11-19)
Picking apart how neurons learn
Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells. view more (2006-03-30)
A possible mechanistic link between stress and the development of Alzheimer tangles
Subjecting mice to repeated emotional stress, the kind we experience in everyday life, may contribute to the accumulation of neurofibrillary tangles, one of the hallmarks of Alzheimer's disease, report researchers at the Salk Institute for Biological Studies. view more (2007-06-18)
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