Plasminogen Current Events | Plasminogen News
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Friend or foe? How the body's clot-busting system speeds up atherosclerosis
Sometimes it's hard to tell friends from foes, biologically speaking. Naturally produced in the body, urokinase plasminogen activator and plasminogen interact to break up blood clots and recruit clean-up cells to clear away debris related to inflammation. In fact, urokinase manufactured as a drug effectively clears clogged arteries by generating... view more... (2008-10-31)
Apolipoprotein(a): A natural regulator of inflammation
In a study to be published in the January 09 issue of Experimental Biology and Medicine, Hoover-Plow and co-workers in seeking to define a role of apo(a) in leukocyte recruitment have identified a novel activity of apo(a) apolipoprotein that may function as a natural and cell specific suppressor of the inflammatory response in vivo. view more (2008-12-29)
Predicting the risk of a common fungal infection after stem cell transplantation
In silico genetic analysis in mice has led to the discovery of a gene affecting susceptibility to a severe fungal infection in transplant recipients. view more (2008-06-20)
Protein complementarity may offer new insights into autoimmune diseases
The discovery of "complementary" antibodies against plasminogen in patients with blood vessel inflammation caused by anti-neutrophil cytoplasmic autoantibodies (ANCAs) may lead to new approaches to research, testing, and treatment of ANCA vasculitis and other autoimmune diseases, suggests a paper in the December Journal of the American... view more... (2008-08-14)
In preeclampsia, researchers identify proteins that cause blood vessel damage
Proteins released by the placenta may damage blood vessels in women with preeclampsia (PE), according to an abstract presented by Yale School of Medicine researchers at the Society for Gynecologic Investigation Conference March 17 in Reno, Nevada. view more (2007-03-19)
Experimental treatment halts hypoxic-ischemic brain injury in newborns
Inhibiting an enzyme in the brains of newborns suffering from oxygen and blood flow deprivation stops a type of brain damage that is a leading cause of cerebral palsy, mental retardation and death, according to researchers at Cincinnati Children's Hospital Medical Center. view more (2009-07-29)
Lowering Body Temperature Could Aid Standard Stroke Treatment
University of Cincinnati (UC) scientists have developed a model that could help physicians combine current clot-busting medication with below-normal body temperatures (hypothermia) to improve the treatment of ischemic stroke patients. view more (2007-05-18)
Elevated biomarkers predict risk for prostate cancer recurrence
A simple blood test screening for a panel of biomarkers can accurately predict whether a patient who has had prostate cancer surgery will have a recurrence or spread of the disease. view more (2008-06-26)
Researchers discover key mechanism to emergence of deadly strep bacteria
The incidence of serious strep infections has risen dramatically in the last three decades, and this increase is largely attributed to the spread around the globe of a single strain of strep known as the invasive M1T1 clone. view more (2007-07-16)
Methamphetamine use increases risks of artery tears and stroke
Methamphetamine use may be associated with increased risks of major neck artery tears and stroke, according to an article published in the December 26, 2006, issue of Neurology, the scientific journal of the American Academy of Neurology. view more (2006-12-26)
Lung damage in babies with congenital heart disease under study
Trying to understand and stop the collateral lung damage that can occur in babies with congenital heart disease is the focus of a new study. view more (2008-03-11)
Ultrasound waves aid in rapid treatment of DVT
The use of ultrasound waves for deep vein thrombosis (DVT) may help dissolve blood clots in less time than using clot-busting drugs alone, according to researchers at Emory University. view more (2008-11-24)
Weill Cornell Team Discovers How Brain's Own tPA Helps Regulate Blood Flow to Neurons
The human brain contains its own store of a powerful enzyme (and stroke drug) called tissue plasminogen activator (tPA), which appears to be a key regulator of blood flow to brain cells, a team at the Weill Cornell Medical College in New York City reports. view more (2008-01-18)
Convincing results: Stopping the spread of cancer in the body
A team of Danish researchers have discovered that by blocking a specific enzyme, it is possible to check the spread of cancer in the body. This finding may be the first step towards preventing deaths due to cancer spreading to other parts of the body. The discovery may also help reduce the amount of chemotherapy used. view more (2004-11-22)
Stroke therapy window might be extended past nine hours for some
Some patients who suffer a stroke as a result of a blockage in an artery in the brain may benefit from a clot-busting drug nine or more hours after the onset of symptoms. The findings are published in the online edition of Radiology. view more (2009-02-09)
Promising cell protein may play role in infection and dry eye
Plasminogen Activator Inhibitor Type 2 (PAI-2), a protein found in various cell types including the skin, has been discovered in the tissue covering the eye and may have future clinical implications in various pathologies of the ocular surface such as eye infection or dry eye. view more (2006-05-17)
Vitamin D inhibits progression of some prostate cancers
Vitamin D can inhibit the spread of prostate cancer cells by limiting the activity of two specific enzymes, University of Rochester Medical Center scientists report. view more (2006-02-09)
ESC Congress 2003: Sudden cardiac death - New drug therapies improve outcome
IMPORTANT: This press release accompanies both a presentation and an ESC press conference given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology ESC Congress 2003: Cold comfort - cough for your life Sudden cardiac death is mostly... view more... (2003-09-02)
Patients who wake up with stroke may be candidates for clot-busters
Giving clot-busting drugs to patients who wake up with stroke symptoms appears to be as safe as giving it to those in the recommended three-hour window, according to researchers at The University of Texas Medical School at Houston. view more (2009-03-13)
ALTERNATIVE PHARMACOLOGICAL STRATEGY FOR TREATMENT OF ACUTE HEART ATTACK (pp 1898, 1905)
Results of the GUSTO V randomised trial - detailed in a fast-track study in this week's issue of THE LANCET - suggest a role for a combination drug strategy for the treatment of acute heart attack. Despite having been the standard of care for acute myocardial infarction (heart attack) since the 1980s, reperfusion (re-establishing blood flow to the... view more... (2001-06-13)
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