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New insights into how the oncogenic protein c-Myc regulates cell growth
New findings by Swedish and German scientists on the regulation of cellular growth are published in the March issue of Nature Cell Biology.   view more (2005-02-20)

Protein binds whenever it can
Dutch cancer researcher Joost Martens has discovered that the protein p300, which plays an important role in the correct transcription of DNA to RNA, can bind to DNA at several sites. The protein can also occupy a position in various complexes, each with its own protein composition. This knowledge... view more (2003-06-24)

Pol3 mutation disrupts organ growth
The cellular mechanism that turns DNA into all of the thousands of proteins that make up a human body is itself both intricate and interesting.   view more (2007-11-27)

Towards a unified model of transcription termination
Dr. David Bentley (University of Colorado School of Medicine) and colleagues have developed a new, unified model for transcription termination by RNA Poymerase II.   view more (2006-04-07)

Genome circularization and RNA virus replication
As featured on the cover of the August 15th issue of G&D, an Argentinian research team, led by Dr. Andrea Gamarnik, report on their recent discovery of a novel mechanism of dengue virus replication.   view more (2006-08-01)

Affibody ligands to Finnzymes
Affibody AB and Finnzymes Oy today announce that they have established a collaboration. The scope of the collaboration is to develop Affibody® affinity ligands for use in amplification of genetic material. Under the agreement, Affibody will develop specific affinity ligands, Affibody®... view more (2004-03-24)

BIOTECHNICA 2003: At the Pulse of the Chip Lab
The clinical and industrial analytics as well as diagnostics show an increasing demand for more sensitive and more rapid detection methods using smallest sample volumes. Within the BMBF joint project "MODULAB" a „chip-based-lab" construction kit is developed in which all the... view more (2003-10-07)

Scientists Identify Key Roadblock to Gene Expression
A team of scientists has provided, for the first time, a detailed map of how the building blocks of chromosomes, the cellular structures that contain genes, are organized in the fruit fly Drosophila melanogaster.   view more (2008-05-09)

From a lowly yeast, researchers divine a clue to human disease
Working with a common form of brewer's yeast, University of Wisconsin-Madison researchers have uncovered novel functions of a key protein that allow it to act as a master regulatory switch - a control that determines gene activity and that, when malfunctioning in humans, may contribute to serious... view more (2006-12-08)

Enzyme alerts cell's powerful army to repair DNA damage
Scientists know that inside each cell, a little engine called RNA polymerase II does one essential job: It copies instructions from genes in the nucleus that get carried to production units in the rest of the cell to support our daily needs.   view more (2007-09-06)

Basic work on E. coli identifies two new keys to regulation of bacterial gene expression
The cellular process of transcription, in which the enzyme RNA polymerase constructs chains of RNA from information contained in DNA, depends upon previously underappreciated sections of both the DNA promoter region and RNA polymerase, according to work done with the bacterium E. coli.   view more (2006-06-19)

Gene-transcription machinery seen poised for action, held in check until needed
For some time, scientists have been tracking down the sequence of biochemical steps required to attract and assemble at the head end of a gene the molecular machinery needed to transcribe that gene to put to work the information it encodes.   view more (2007-07-26)

Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
Everyone knows mutations - genetic mistakes in DNA, the material of heredity - are bad: The more mutations in the cell's DNA, the higher the risk of cancer developing.   view more (2006-05-05)

DNA size a crucial factor in genetic mutations, study finds
Researchers at Stanford University have created a larger-than-normal DNA molecule that is copied almost as efficiently as natural DNA.   view more (2005-10-27)

Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego (UCSD) took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system.   view more (2006-12-08)

What Are Muscle Proteins Doing in the Nucleus?
The proteins actin and myosin have a firm place in the muscles where they are responsible for contraction. While recent investigations have shown that they are also found in the nucleus, it has been unclear to date just what they are doing there. Now an international team of investigators headed by... view more (2005-02-01)

New findings shed light to the mechanisms of Parkinson's disease
The findings of Finnish scientists with their multinational collaborators shed light to the mechanisms of Parkinson's disease and early menopause.   view more (2004-09-07)

Professors to develop hand-held pathogen testing device
Testing for deadly food, air and water pathogens may get a lot easier and cheaper thanks to the work of a Michigan State University researcher and his team.   view more (2006-12-19)

Newly described 'dragon' protein could be key to bird flu cure
Scientists and researchers have taken a big step closer to a cure for the most common strain of avian influenza, or "bird flu," the potential pandemic that has claimed more than 200 lives and infected nearly 400 people in 14 countries since it was identified in 2003.   view more (2008-07-16)

Getting wise to the influenza virus' tricks
Influenza is currently a grave concern for governments and health organisations around the world. The worry is the potential for highly virulent bird flu strains, such as H5N1, to develop the ability to infect humans easily. New drugs and vaccines to halt the spread of the virus are badly needed.   view more (2008-05-05)

Molecule crucial for processing non-coding RNA identified
The discovery in 1977 that the coding regions of a gene could appear in separate segments along the DNA won the 1993 Nobel Prize in Physiology or Medicine for Richard J. Roberts and Phillip A. Sharp.   view more (2005-10-21)

Discovery may help defang viruses
Researchers may be able to tinker with a single amino acid of an enzyme that helps viruses multiply to render them harmless, according to molecular biologists who say the discovery could pave the way for a fast and cheap method of making vaccines.   view more (2007-08-29)

Advances in HBV DNA assays are key to determine best long-term treatment strategies for Hepatitis B
For the 350 million people chronically infected with HBV, the two therapeutic approaches currently available are immunomodulatory agents and antiviral chemotherapy. The first therapeutic agent was interferon-alpha (IFN-alpha), whose dual mode of action includes both antiviral and immunomodulatory... view more (2005-01-10)

Common Enzyme is a Key Player in DNA Repair
A quarter century after they discovered it, researchers have identified the job of one of the most common DNA-damage response proteins.   view more (2006-01-12)

Novel experiment documents evolution of genome in near-real time
A team led by bioengineering researchers at UC San Diego report in the November issue of Nature Genetics rapid evolutionary changes in a bacterial genome, observed in near-real time over a few days.   view more (2006-11-06)
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