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New insights into how the oncogenic protein c-Myc regulates cell growth
New findings by Swedish and German scientists on the regulation of cellular growth are published in the March issue of Nature Cell Biology. view more (2005-02-20)
Bird flu leaves the nest -- adapting to a new host
Current research suggests that viral polymerase may provide a new therapeutic target for host-adapted avian influenza. view more (2009-08-27)
Molecular typesetting -- proofreading without a proofreader
Researchers at the Universities of Leeds and Bristol (UK) have developed a model of how errors are corrected whilst proteins are being built. view more (2009-06-23)
Protein binds whenever it can
Dutch cancer researcher Joost Martens has discovered that the protein p300, which plays an important role in the correct transcription of DNA to RNA, can bind to DNA at several sites. The protein can also occupy a position in various complexes, each with its own protein composition. This knowledge is important for gaining a better understanding of... view more... (2003-06-24)
Properties of Unusual Virus Revealed in Researchers
A team of researchers from Penn State University and the University of Chicago has uncovered clues that may explain how and why a particular virus, called N4, injects an unusual substance -- an RNA polymerase protein -- into an E. coli bacterial cell. The results, which are published in the current issue of the journal Molecular Cell, contribute... view more... (2008-12-09)
Pol3 mutation disrupts organ growth
The cellular mechanism that turns DNA into all of the thousands of proteins that make up a human body is itself both intricate and interesting. view more (2007-11-27)
New Piece Found in the Puzzle of Epigenetics
A team of scientists led by Professor Dirk Eick of Helmholtz Zentrum München has identified the enzyme TFIIH kinase as an important factor in the epigenetic regulation of the cell nucleus enzyme RNA polymerase II. view more (2009-06-17)
Towards a unified model of transcription termination
Dr. David Bentley (University of Colorado School of Medicine) and colleagues have developed a new, unified model for transcription termination by RNA Poymerase II. view more (2006-04-07)
Genome circularization and RNA virus replication
As featured on the cover of the August 15th issue of G&D, an Argentinian research team, led by Dr. Andrea Gamarnik, report on their recent discovery of a novel mechanism of dengue virus replication. view more (2006-08-01)
Affibody ligands to Finnzymes
Affibody AB and Finnzymes Oy today announce that they have established a collaboration. The scope of the collaboration is to develop Affibody® affinity ligands for use in amplification of genetic material. Under the agreement, Affibody will develop specific affinity ligands, Affibody® molecules, to be used in kits for HotStart polymerase... view more... (2004-03-24)
BIOTECHNICA 2003: At the Pulse of the Chip Lab
The clinical and industrial analytics as well as diagnostics show an increasing demand for more sensitive and more rapid detection methods using smallest sample volumes. Within the BMBF joint project "MODULAB" a „chip-based-lab" construction kit is developed in which all the necessary working steps can be performed in separate... view more... (2003-10-07)
How RNA polymerase II gets the go-ahead for gene transcription
All cells perform certain basic functions. Each must selectively transcribe parts of the DNA that makes up its genome into RNAs that specify the structure of proteins. view more (2009-10-12)
Scientists Identify Key Roadblock to Gene Expression
A team of scientists has provided, for the first time, a detailed map of how the building blocks of chromosomes, the cellular structures that contain genes, are organized in the fruit fly Drosophila melanogaster. view more (2008-05-09)
From a lowly yeast, researchers divine a clue to human disease
Working with a common form of brewer's yeast, University of Wisconsin-Madison researchers have uncovered novel functions of a key protein that allow it to act as a master regulatory switch - a control that determines gene activity and that, when malfunctioning in humans, may contribute to serious neurological disorders. view more (2006-12-08)
Evolution in action: Our antibodies take 'evolutionary leaps' to fight microbes
With cold and flu season in full swing, the fact that viruses and bacteria rapidly evolve is apparent with every sneeze, sniffle, and cough. A new report in the January 2009 issue of The FASEB Journal, explains for the first time how humans keep up with microbes by rearranging the genes that make antibodies to foreign invaders. This research fills... view more... (2009-01-06)
Enzyme alerts cell's powerful army to repair DNA damage
Scientists know that inside each cell, a little engine called RNA polymerase II does one essential job: It copies instructions from genes in the nucleus that get carried to production units in the rest of the cell to support our daily needs. view more (2007-09-06)
Basic work on E. coli identifies two new keys to regulation of bacterial gene expression
The cellular process of transcription, in which the enzyme RNA polymerase constructs chains of RNA from information contained in DNA, depends upon previously underappreciated sections of both the DNA promoter region and RNA polymerase, according to work done with the bacterium E. coli. view more (2006-06-19)
Gene-transcription machinery seen poised for action, held in check until needed
For some time, scientists have been tracking down the sequence of biochemical steps required to attract and assemble at the head end of a gene the molecular machinery needed to transcribe that gene to put to work the information it encodes. view more (2007-07-26)
Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
Everyone knows mutations - genetic mistakes in DNA, the material of heredity - are bad: The more mutations in the cell's DNA, the higher the risk of cancer developing. view more (2006-05-05)
DNA size a crucial factor in genetic mutations, study finds
Researchers at Stanford University have created a larger-than-normal DNA molecule that is copied almost as efficiently as natural DNA. view more (2005-10-27)
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