Prion Protein Current Events | Prion Protein News
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Mutant proteins result in infectious prion disease in mice
A worldwide group of scientists has created an infectious prion disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals. view more (2008-12-08)
New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease. "Our team has defined a second prion protein called 'Shadoo', that exists in addition to the well-known prion protein called 'PrP' " said Professor David Westaway, director of the Centre for Prions and Protein Folding Diseases... view more... (2007-08-17)
Scientists find the pathological prion protein in skeletal muscles of hamster with scrapie
In the May 2003 issue of EMBO reports, researchers from the German Robert Koch Institute in Berlin report finding the pathological prion protein PrPSc in a wide range of skeletal muscles after feeding hamsters with prion-infected food. PrPSc is believed to be an essential - if not the sole - constituent of the agent that causes BSE in cattle,... view more... (2003-04-10)
Is there more to prion protein than mad cow disease?
Prion protein, a form of protein that triggers BSE, is associated with other brain diseases in cattle, raising the possibility of a significant increase in the range of prion disease. view more (2008-09-30)
Urgent need for more research into prevalence of CJD
The first estimate of the number of people who are at increased risk of vCJD, but who have not developed symptoms, is published in this week`s BMJ. Researchers studied specimens from appendicectomies and tonsillectomies carried out between 1995 and 1999. They also examined samples removed at autopsy or during surgery from... view more... (2002-09-18)
Prion discovery gives clue to control of mass gene expression
The discovery in common brewer's yeast of a new, infectious, misfolded protein -- or prion -- by University of Illinois at Chicago molecular biologists raises new questions about the roles played by these curious molecules, often associated with degenerative brain diseases like "mad cow" and its human counterpart, Creutzfeldt-Jakob. view more (2009-03-16)
New study raises questions about the number of people in the UK who could be incubating vCJD
A team of UK scientists found that 3 out of 12,674 stored appendix and tonsil samples showed evidence of the prion protein associated with vCJD, but urge caution about the way these results are interpreted. The research is published this week in The Journal of Pathology. The study aimed to help health policymakers estimate the numbers of people... view more... (2004-05-18)
New insights into the diversity of Creutzfeldt-Jakob disease agents
Researchers from the United Kingdom and France have identified four separate biochemical subgroups in a selection of cases of Creutzfeldt-Jakob disease. view more (2008-03-18)
Antibody key to treating variant CJD, scientists find
Scientists at the University of Liverpool have determined the atomic structure of the 'binding' between a brain protein and an antibody that could be key to treating patients with diseases such as variant CJD. view more (2009-03-04)
U of T led research team uncovers evolutionary origins of prion disease gene
A University of Toronto-led team has uncovered the evolutionary ancestry of the prion gene, which may reveal new understandings of how the prion protein causes diseases such as bovine spongiform encephalopathy (BSE), also known as "mad cow disease." view more (2009-09-29)
Prions link cholesterol to neurodegeneration
Prion infection of neurons increases the free cholesterol content in cell membranes. A new study published in the online open access journal BMC Biology suggests that disturbances in membrane cholesterol may be the mechanism by which prions cause neurodegeneration and could point to a role for cholesterol in other neurodegenerative diseases. view more (2008-02-12)
A Penny for Your Prions
North Carolina State University researchers have discovered a link between copper and the normal functioning of prion proteins, which are associated with transmissible spongiform encephalopathy diseases such as Cruetzfeldt-Jakob in humans or "mad cow" disease in cattle. view more (2009-06-26)
Iron is involved in prion disease-associated neuronal demise
Imbalance of iron homeostasis is a common feature of prion disease-affected human, mouse, and hamster brains, according to a new study by Dr. Neena Singh and colleagues at Case Western Reserve University School of Medicine, alongside collaborators from Creighton University. view more (2009-03-16)
Deadly infectious entity of prions discovered
The mysterious, highly infectious prions, which cause the severe destruction of the brain that characterizes "mad cow disease" and several human brain degenerative disorders, can be rendered harmless in the laboratory by a slight alternation of the three-dimensional conformation or shape of the prion protein's structure. view more (2005-06-10)
BSE link to new variant CJD is open to question
The link between the bovine spongiform encephalopathy (BSE) prion and new variant Creutzfeldt-Jakob disease is open to question, argues George Venters, Consultant in Public Health Medicine, in this week's BMJ. He applied standard criteria - used to establish links between cause and disease - to the case for the BSE prion being the cause of new... view more... (2001-10-09)
The Protein Srebp2 Drives Cholesterol Formation in Prion-Infected Neuronal Cells Which May Promote Prion-Dependent Diseases
The regulating protein Srebp2 drives cholesterol formation, which prions need for their propagation, in prion-infected neuronal cells. view more (2009-11-19)
Prion Research Center to open today - Hebrew University-hadassah Medical School Researchers Working To Prevent Mad Cow Disease
Prion Research Center to open today Jerusalem, July 31, 2002 - Scientists around the world are striving to learn as much as possible about the phenomenon that causes mad cow disease so that they will be prepared if and when an epidemic breaks out, according to Dr. Albert Taraboulos of the Institute of Microbiology of the Hebrew University-Hadassah... view more... (2002-07-31)
Southampton researchers develop novel method for detecting vCJD prions on surgical instruments
Researchers from the University of Southampton, together with Surrey-based diagnostics company, Microgen Bioproducts Limited, and microscopy specialists, Best Scientific of Swindon, are developing important new methods for detecting prions- the proteins implicated in sporadic and variant Creutzfeld-Jakob disease (CJD) - on surgical instruments.... view more... (2002-09-26)
Vaccine prevents prion disease in mice
An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease. view more (2007-05-04)
Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
One of the new in vitro tests, called the Standard Scrapie Cell Assay, measures prion infectivity levels in a highly accurate and extremely rapid way, producing results in less than two weeks. view more (2007-12-05)
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