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Workman Lab characterizes novel regulator of chromosome function
The Stowers Institute's Workman Lab has shed new light on a novel histone acetyltransferase protein complex called ATAC. Acetyltransferases are enzymes that introduce a new acetyl functional group into histone proteins, a process by which all chromosome functions are controlled. view more (2008-03-11)
Compound reveals new link between signaling protein and cell migration
University of Illinois at Chicago researchers report that a protein that regulates key signaling pathways in cells also plays a role in controlling the active movement or migration of cells. view more (2005-09-26)
Scientists on track for early diagnosis of neurological diseases
Possible treatments for fatal neurodegenerative diseases such as CJD, Alzheimer's, Parkinson's could result from University of Edinburgh research to find out how specific proteins cause deterioration in brain function. The scientists have discovered for the first time that protein 14-3-3 plays a key role in the development of certain brain... view more... (2003-07-01)
HIV isolate from Kenya provides clues for vaccine design
Two simple changes in its outer envelope protein could render the AIDS virus vulnerable to attack by the immune system, according to research from Kenya and the Fred Hutchinson Cancer Research Center published in PLoS Medicine. view more (2008-01-03)
Viral oncoprotein inactivation of p53
A group of scientists led by USC researcher Dr. Xiaojiang Chen lend structural insight into tumor suppressor inactivation by a viral oncoprotein. view more (2006-09-01)
Protein may predict heart attack and early death, not stroke
People with high levels of a protein called C-reactive protein (CRP), a marker for inflammation in the blood, may be at higher risk for heart attack and death but not stroke, according to a study published in the October 20, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology. view more (2009-10-20)
Zeroing in on Alzheimer's
Hereditary Alzheimer's disease has been shown to be the result of mutations in certain specific genes. Other cases of Alzheimer's are also assumed to be traceable to the influence of a number of still unidentified genes. It is probable that these genes are located in a large area on chromosome 10q, which contains more than 100 genes. Working with... view more... (2003-09-25)
Protein identified that turns off HIV-fighting T cells
In HIV-infected patients the body's immune system is unable to fight off the virus. A new study to be published online on November 10th in the Journal of Experimental Medicine shows that T cells in HIV-infected individuals express a protein called TIM-3, which inactivates their virus killing capacity. view more (2008-11-10)
Nature press release for 16 August issue
[412736] LIFELINES: SIEVING FOR STEM CELL GOLD (pp736-739; N&V) Researchers hunting for the elusive stem cell in adult brains narrow the search to a small pool of suspects in this week’s Nature. Adult brain stem cells offer hope for tissue replacement in brain injury and degenerative diseases such as Parkinson’s amid intensifying... view more... (2001-08-16)
Researchers report the cloning of a key group of human genes, the protein kinases
Although the human genome has been sequenced, research into mechanism of action of genes has been hampered by the fact that most human genes have not been isolated. This is true for even the most common class of cancer-associated genes, the protein kinases, which mediate the majority of signaling events in cells by phosphorylating and modulating... view more... (2008-05-05)
Using plastics to track down prions
BSE still remains a highly emotive subject. Consumers of beef products are not the only ones to have lingering doubts: Scientific experts point out that there may still be a risk of contamination from the cinders and ashes left over when infected animal carcasses are incinerated. The reason for their caution is that, despite intensive research, we... view more... (2002-06-07)
NIST trumps the clumps: Making biologic drugs safer
Scientists at the National Institute of Standards and Technology (NIST) have developed a technique to measure the formation of clumps of proteins in protein-based pharmaceuticals. view more (2008-07-24)
Researchers discover cell's 'quality control' mechanism
Researchers in Japan and Canada have discovered a key component of the quality control mechanism that operates inside human cells - sometimes too well. The breakthrough has significant implications for the development of new treatments for cystic fibrosis (CF) and some other hereditary diseases, the researchers say. Their results were published... view more... (2008-07-30)
Scientists learn more about how viruses reproduce, spread
Biochemists at Wake Forest University School of Medicine have made a surprising discovery about the inner workings of a powerful virus - a discovery that they hope could one day lead to better vaccines or anti-virus medications. view more (2006-04-07)
Mayo Clinic researchers measuring C-reactive protein is early indicator of stiffened arteries
Researchers around the world agree that C-reactive protein is associated with increased risk of heart attack and stroke. view more (2005-08-24)
High protein diet may be bad for women trying to conceive
A moderately high protein diet could reduce a woman's chances of becoming pregnant, according to new research presented at the 20th annual conference of the European Society of Human Reproduction and Embryology today on Monday 28 June. Researchers from the USA have found that a diet containing 25% protein disrupted the normal genetic imprinting... view more... (2004-06-28)
Infections may lead to faster memory loss in Alzheimer's disease
Getting a cold, stomach bug or other infection may lead to increased memory loss in people with Alzheimer's disease. view more (2009-09-08)
Moderate amounts of protein per meal found best for building muscle
For thousands of years, people have believed that eating large amounts of protein made it easier to build bigger, stronger muscles. Take Milo of Croton, the winner of five consecutive Olympic wrestling championships in the sixth century BC: If ancient writers are to be believed, he built his crushing strength in part by consuming 20 pounds of meat... view more... (2009-10-27)
Penn biologists discover how 'silent' mutations influence protein production
Biologists at the University of Pennsylvania have revealed a hidden code that determines the expression level of a gene, providing a way to distinguish efficient genes from inefficient ones. view more (2009-04-10)
Crystal structure enables tailoring of pharmaceuticals against asthma
Researchers at Karolinska Institutet in Sweden have managed to elucidate the crystal structure of a human membrane protein - LTC4 synthase - which has a major influence on the development of asthma. view more (2007-07-17)
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