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MU scientists 'see' how HIV matures into an infection
After improving the sensitivity of nuclear magnetic resonance (NMR), researchers at the University of Missouri actually watched the HIV-1 protease mature from an inactive form into an active infection. This process has never been directly visualized before. The findings appear today in the journal... view more (2008-10-02)
Compound has potential for new class of AIDS drugs
Researchers have developed what they believe is the first new mechanism in nearly 20 years for inhibiting a common target used to treat all HIV patients, which could eventually lead to a new class of AIDS drugs. view more (2008-05-15)
Specific Genotype Could Increase Resistance To HIV Drug Therapy (p 383)
A specific mutation of a gene which influences the expression of a glycoprotein transporter protein involved in the body's resistance to drugs and other toxins is detailed in a research letter in this week's issue of THE LANCET. Results of the study suggest that drug therapies used in treating... view more (2001-08-01)
Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
UCLA scientists, along with collaborators from Purdue University, have demonstrated that HIV protease inhibitors - crucial drugs for HIV treatment - block a cellular enzyme important for generating the structural scaffolding for the cell nucleus. view more (2007-07-17)
Abacavir Could Play Important Future Role In Treatment Of Children With HIV-1 (p 733)
Results of the Paediatric European Network for Treatment of AIDS (PENTA) 5 Trial, published in this week's issue of THE LANCET, suggest an important future role for the drug abacavir in the treatment of children with HIV-1. Antiretroviral HIV-1 drug treatment for adults in more-developed countries... view more (2002-02-28)
Curacyte scientists discover new anti-tumour agents
Curacyte AG, a Munich-based drug development company focused on novel treatments of inflammatory diseases, thrombotic disorders and cancer has announced today that its scientists have discovered a series of novel small molecule inhibitors of matriptase, a trypsin-like serine protease. Matriptase is... view more (2003-06-17)
UCSB researchers discover new biotechnology to identify
Researchers at UC Santa Barbara have developed a new biotechnology that enables scientists to identify and engineer protease substrates, giving them the means of crafting pharmaceuticals to outsmart disease. view more (2006-05-02)
Gentech breakthough for ecological Chrysanthemums
Researchers at Plant Research International in the Netherlands have achieved a breakthrough in the development of chrysanthemums with resistance to thrips, bringing the ecological cultivation of chrysanthemums a step closer. This is the conclusion of the thesis with which Seetharam Annadana, a... view more (2001-12-13)
Metal-containing compounds show promise as HIV weapon
A molecule consisting of two "cages" of metallic atoms bound to carbon has shown great promise in preliminary tests of becoming a new weapon in the anti-HIV arsenal, researchers at UT Southwestern Medical Center report. view more (2005-11-01)
Drug combo may reduce protease inhibitor-related hardening of the arteries
Physiologists may have found a way to decrease the risk of hardening of the arteries that accompanies the long-term use of protease inhibitors, a class of drugs that has emerged as the most effective treatment against HIV and AIDS. view more (2006-09-05)
Ethnic differences in response to HIV medicines
Researchers from the University of Massachusetts and the University of Pennsylvania have shown that race/ethnicity is a predictor of plasma lipids in patients with HIV-1 on HAART (highly active antiretroviral therapy). view more (2006-01-24)
Leeches provide source for cardiovascular drugs
The leech has recently confirmed its biomedical interest for scientists by showing that it contains an extensive list of new potential molecules that may become useful tools in the treatment of cardiovascular diseases. view more (2005-10-26)
Enzyme inhibitors block replication Of SARS virus
Researchers have known since 2003 that a site on the virus is responsible for mediating proteases that allow the virus to replicate. Since then researchers have been testing protease inhibitors to lock up this site, known as SARS 3CLpro, and effectively stop the virus from infecting additional... view more (2006-03-28)
Newly discovered small molecules
According to the study, these activators bind to specific sites on the neurotoxin protein, increasing protease activity and enhancing the toxin's effect. view more (2006-03-15)
How flesh-eating bacteria attack the body's immune system
"Flesh-eating" or "Strep" bacteria are able to survive and spread in the body by degrading a key immune defense molecule, according to researchers at the University of California, San Diego, School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences. view more (2008-08-14)
The UAB heads a European research project on proteases and pathological processes
A research group of the UAB Institute of Biotechnology and Biomedicine and the UAB Department of Biochemistry and Molecular Biology, directed by Francesc Xavier Avilés, is the coordinator of a European project aimed at studying proteases with fluorescent molecules that allow their monitoring... view more (2007-07-18)
Viral 'fitness' explains different resistance patterns to aids drugs
Some HIV medications lead to the development of drug-resistant HIV when patients take as few as two percent of their medications. view more (2006-01-11)
Potential Alzheimer's disease drug target identified by UC San Diego researcher
In findings with the potential to provide a therapy for Alzheimer's disease patients where none now exist, a researcher at the University of California, San Diego and colleagues have demonstrated in mice a way to reduce the overproduction of a peptide associated with the disease. view more (2008-03-17)
An effective method to study the pressure of the Sphincter of Oddi
The Sphincter of Oddi (SO) plays a vital role in maintaining the normal bile duct pressure, promoting gallbladder excretion and preventing from reflux. view more (2008-10-24)
LIPODYSTROPHY RISK FROM HIV-1 THERAPY (p 592)
The risk of lipodystrophy (abnormal fat distribution) in HIV-1 individuals undergoing antiretroviral therapy cannot be attributed to one antiretroviral agent, conclude authors of a study in this week's issue of THE LANCET. Lipodystrophy among HIV-1-infected patients receiving antiretroviral therapy... view more (2001-02-21)
Curacyte awarded a EUR1.2M grant to fund development of Factor Xa inhibitors
Curacyte AG, a Munich-based drug development company, has announced that its wholly owned subsidiary, Curacyte Chemistry GmbH based in Jena, has been awarded a EUR1.2M R&D grant from the German State of Thuringia's Corporate Technology Development Program. The grant will fund the lead optimization... view more (2003-10-29)
Casting a wide net to fight coronaviruses
Coronaviruses-the family of viruses that causes the common cold-gained widespread recognition when the deadly severe acute respiratory syndrome, familiarly known as SARS, killed at least 800 people in 2003. view more (2005-09-06)
First results of the Narval trial (ANRS 088)
Patients with HIV infection may develop resistance to one or more of antiretroviral drugs to which they are exposed during treatment. The selection of the most appropriate drugs for switching therapy in patients who have developed resistance, is a difficult challenge. Both, genetic tests that... view more (2000-04-21)
Researchers probe enzyme that may lead to new SARS drugs
Researchers at the University of Illinois at Chicago and two other institutions have unraveled the structure of an important new drug target from the virus that causes SARS, severe acute respiratory syndrome. view more (2006-04-05)
SLU Researchers Uncover Direct Evidence on How HIV Invades Healthy Cells
Using sophisticated detection methods, researchers at the Saint Louis University Institute for Molecular Virology (IMV) have demonstrated the molecular mechanism by which the HIV virus infects, or integrates, healthy cells. The discovery could lead to new drug treatments for HIV. view more (2005-12-22)
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